2. Gene
  3. CASP7 - caspase 7 Gene

CASP7 - caspase 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3

Gene ID: 840 | Gene type: protein coding

About CASP7

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:113,679,194-113,730,909 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and 16 paralogues. Broad expression in colon (RPKM 28.2), small intestine (RPKM 22.7) and 25 other tissues.

Summary

This gene encodes a member of the cysteine-aspartic acid Protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active Enzyme. The precursor of the encoded protein is cleaved by Caspase 3 and 10, is activated upon cell death stimuli and induces Apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

CASP7 Products(11)

mRNA Protein Name
XM_006718017.4 XP_006718080.1 caspase-7 isoform X2
NM_001227.5 NP_001218.1 caspase-7 isoform alpha precursor
NM_033338.6 NP_203124.1 caspase-7 isoform delta
NM_033340.4 NP_203126.1 caspase-7 isoform beta
XM_011540260.2 XP_011538562.1 caspase-7 isoform X3
NM_001267058.2 NP_001253987.1 caspase-7 isoform f
NM_033339.5 NP_203125.1 caspase-7 isoform alpha precursor
NM_001267057.1 NP_001253986.1 caspase-7 isoform e
XM_017016763.2 XP_016872252.1 caspase-7 isoform X1
NM_001267056.2 NP_001253985.1 caspase-7 isoform alpha precursor
NM_001320911.2 NP_001307840.1 caspase-7 isoform g
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
31586028 GOA
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
17646170 GOA
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
11257230 GOA
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IDA
IDA: Inferred from direct assay
16123041 GOA
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
22253444 GOA
enables peptidase activity IDA
IDA: Inferred from direct assay
19740745 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11084335 GOA
Biological Process GO Annotation Evidence Reference Source
involved in apoptotic process IDA
IDA: Inferred from direct assay
17464193 GOA
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
22464733 GOA
involved in cellular response to staurosporine IMP
IMP: Inferred from mutant phenotype
22253444 GOA
involved in execution phase of apoptosis IDA
IDA: Inferred from direct assay
16374543 GOA
involved in protein catabolic process IDA
IDA: Inferred from direct assay
16374543 GOA
involved in protein maturation IDA
IDA: Inferred from direct assay
21157428 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
12888622 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
21555521 GOA
is active in cytosol IDA
IDA: Inferred from direct assay
16352606 GOA
located in cytosol IDA
IDA: Inferred from direct assay
17167422 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
16374543 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17167422 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP7 Protein Structure

Peptidase_C14

Peptidase_C14: Caspase domain (68 - 301)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

caspase-7

ICE-like apoptotic protease 3

apoptotic protease MCH-3

caspase 7, apoptosis-related cysteine peptidase

caspase 7, apoptosis-related cysteine protease

Recombinant CASP7 Proteins

Cat. No. Product Name Accession Purity
HY-P74347 Caspase-7/CASP7 Protein, Human (His) P55210 (M1-Q303) ≥95%

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma
Robinow Syndrome, Autosomal Dominant 3

Autosomal Dominant Robinow Syndrome 3

DRS3

Robinow, Autosomal Dominant Syndrome, Type 3
Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Type 1 Diabetes Mellitus 17

Diabetes Mellitus, Insulin-Dependent, 17

Iddm17

Insulin-Dependent Diabetes Mellitus 17

TID17

Insulin-Dependent Diabetes Mellitus-17
Acute Laryngopharyngitis

Pharyngolaryngitis

Laryngopharyngitis

Hypopharyngitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01962 CASP7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01963 Casp7 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01964 Casp7 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CASP7 VGNC VGNC:26783
Mus musculus CASP7 MGD MGI:109383
Macaca mulatta CASP7 VGNC VGNC:70546
Rattus norvegicus CASP7 RGD RGD:620944
Canis familiaris CASP7 VGNC VGNC:38735
Felis catus CASP7 VGNC VGNC:60383
Others CASP7 NCBI