HTRA4 - HtrA serine peptidase 4 Gene

Homo sapiens

Gene ID: 203100 | Gene type: protein coding

About HTRA4

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:38,974,228-38,988,663 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and 3 paralogues. Biased expression in placenta (RPKM 16.9) and bone marrow (RPKM 1.2).

Summary

This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an Insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on Other related family members, this Enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, Apoptosis, and aging. [provided by RefSeq, Oct 2008]

HTRA4 Products(1)

mRNA	Protein	Name
NM_153692.4	NP_710159.1	serine protease HTRA4 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	18387192	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25002585	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25002585	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proteolysis	IDA IDA: Inferred from direct assay	18387192	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTRA4 Protein Structure

Kazal_2

Trypsin_2

PDZ_2

0
100
200
300
400
476 a.a.

Protein Preferred Names

Protein Names

serine protease HTRA4

high-temperature requirement factor A4

HTRA4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HTRA4	P83105	HTRA4	Homo sapiens	P83105	GMS	31470122
Intra	HTRA4	P83105	CASP7	Homo sapiens	P55210	Anti Bait CoIP	31470122
Intra	HTRA4	P83105	XIAP	Homo sapiens	P98170	Pull Down	31036715
Intra	HTRA4	P83105	XIAP	Homo sapiens	P98170	ELISA	31470122
Intra	HTRA4	P83105	XIAP	Homo sapiens	P98170	PLA	31470122
Intra	HTRA4	P83105	XIAP	Homo sapiens	P98170	Anti Bait CoIP	31470122
Intra	HTRA4	P83105	CASP7	Homo sapiens	P55210	Pull Down	31470122
Intra	HTRA4	P83105	CASP7	Homo sapiens	P55210	PLA	31470122
Intra	HTRA4	P83105	HTRA4	Homo sapiens	P83105	GMS	31036715
Intra	HTRA4	P83105	XIAP	Homo sapiens	P98170	Protease Assay	31036715
Intra	HTRA4	P83105	XIAP	Homo sapiens	P98170	Pull Down	31470122
Intra	HTRA4	P83105	CASP7	Homo sapiens	P55210	Confocal	31470122
Intra	HTRA4	P83105	HTRA4	Homo sapiens	P83105	Protease Assay	25002585
Intra	HTRA4	P83105	XIAP	Homo sapiens	P98170	Confocal	31470122
Intra	HTRA4	P83105	HTRA3	Homo sapiens	P83110	Protease Assay	25002585
Intra	HTRA4	P83105	HTRA3	Homo sapiens	P83110	Anti Tag CoIP	25002585
Intra	HTRA4	P83105	HTRA1	Homo sapiens	Q92743	Anti Tag CoIP	25002585
Intra	HTRA4	P83105	HTRA1	Homo sapiens	Q92743	Protease Assay	25002585
Intra	HTRA4	P83105	TCP1	Homo sapiens	P17987	PLA	31470122
Intra	HTRA4	P83105	TCP1	Homo sapiens	P17987	Anti Bait CoIP	31470122
Intra	HTRA4	P83105	TCP1	Homo sapiens	P17987	ELISA	31470122
Intra	HTRA4	P83105	TCP1	Homo sapiens	P17987	Confocal	31470122
Intra	HTRA4	P83105	TCP1	Homo sapiens	P17987	Pull Down	31470122
Cross	HTRA4	P83105	CSN2	Bos taurus	P02666	GMS	31036715
Cross	HTRA4	P83105	CSN2	Bos taurus	P02666	Protease Assay	31036715

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06489	HTRA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HTRA4	RGD	RGD:1306242
Macaca mulatta	HTRA4	VGNC	VGNC:73447
Mus musculus	HTRA4	MGD	MGI:3036260
Felis catus	HTRA4	VGNC	VGNC:62857
Canis familiaris	HTRA4	VGNC	VGNC:41838
Bos taurus	HTRA4	VGNC	VGNC:30006

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