ZNRF3 - zinc and ring finger 3 Gene

Homo sapiens

Also known as RNF203; BK747E2.3

Gene ID: 84133 | Gene type: protein coding

About ZNRF3

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:28,883,572-29,057,488 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues, 1 paralogue and is associated with 81 phenotypes. Ubiquitous expression in kidney (RPKM 4.8), brain (RPKM 4.7) and 24 other tissues.

Summary

Enables Frizzled binding activity and ubiquitin-protein transferase activity. Involved in cellular protein metabolic process and negative regulation of Wnt signaling pathway. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZNRF3 Products(2)

mRNA	Protein	Name
NM_001206998.2	NP_001193927.1	E3 ubiquitin-protein ligase ZNRF3 isoform 1 precursor
NM_032173.4	NP_115549.2	E3 ubiquitin-protein ligase ZNRF3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables frizzled binding	IPI IPI: Inferred from physical interaction	22575959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22575959	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	22575959	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt receptor catabolic process	IMP IMP: Inferred from mutant phenotype	22575959	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22575959	GOA
involved in negative regulation of non-canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22575959	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	22575959	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22575959	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22575959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNRF3 Protein Structure

zf-RING_2

0
200
400
600
800
936 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase ZNRF3

CTA-292E10.6

ZNRF3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNRF3	Q9ULT6	RSPO1	Homo sapiens	Q2MKA7	SPR	24165923
Intra	ZNRF3	Q9ULT6	RSPO1	Homo sapiens	Q2MKA7	Pull Down	22575959
Intra	ZNRF3	Q9ULT6	RSPO1	Homo sapiens	Q2MKA7	Anti Tag CoIP	22575959
Intra	ZNRF3	Q9ULT6	LGR4	Homo sapiens	Q9BXB1	Anti Tag CoIP	22575959
Intra	ZNRF3	Q9ULT6	FZD6	Homo sapiens	O60353	Anti Bait CoIP	22575959
Intra	ZNRF3	Q9ULT6	LRP6	Homo sapiens	O75581	Anti Bait CoIP	22575959

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZNRF3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78750	ZNRF3 Protein, Human (HEK293, His)	Q9ULT6-1 (K56-M219)	≥95%

Related Diseases

Diseases

Alias

Adrenal Carcinoma

Adrenal Cancer	Adrenal Gland Cancer
Malignant Neoplasm Of Adrenal Gland	Adrenal Gland Neoplasms
Carcinoma Of The Adrenal Gland	Adrenal Neoplasm
Malignant Adrenal Tumor	Neoplasm Of Adrenal Gland
Tumor Of The Adrenal Gland	Adrenal Gland Neoplasm
Adrenocortical Carcinoma	Adrenal Gland Malignancy
Suprarenal Cancer	Malignant Neoplasm Of Suprarenal Gland
Malignant Neoplasm Of Adrenal Gland, Unspecified	Malignant Tumour Of Adrenal Gland
Suprarenal Gland Cancer	Primary Malignant Neoplasm Of Adrenal Gland

Tetraamelia Syndrome

Tetra-Amelia Syndrome	Tetraamelia-Multiple Malformations Syndrome
Tetra-Amelia	Tetra-Amelia, Autosomal Recessive
Tetraamelia, Autosomal Recessive	Total Amelia
Zimmer Phocomelia	Tetams
Zimmer Taub Sova Syndrome

Uterine Corpus Endometrial Carcinoma

Osteoblastoma

Adrenal Cortex Disease

Adrenal Cortex Diseases

Skin Melanoma

Cutaneous Melanoma	Malignant Ear Melanoma
Malignant Lip Melanoma	Malignant Lower Limb Melanoma
Malignant Melanoma Of Ear And/Or External Auricular Canal	Malignant Melanoma Of Skin Of Lower Limb
Malignant Melanoma Of Skin Of Trunk Except Scrotum	Malignant Melanoma Of Skin Of Upper Limb
Malignant Neck Melanoma	Malignant Scalp Melanoma
Malignant Trunk Melanoma	Malignant Upper Limb Melanoma
Melanoma, Cutaneous Malignant	Melanoma
Malignant Melanoma Of Skin	Melanoma Nos
Malignant Mole, Meaning Melanoma Of Unspecified Site	Melanoma Of Unspecified Site
Cutaneous Malignant Melanoma	Mm - [Malignant Melanoma]

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma	Adrenal Cortex Carcinoma
Carcinoma Of The Adrenal Cortex	Acc
Adrenocortical Cancer	Carcinoma Adrenocortical

Carney Complex Variant

Carney Complex	Carney Syndrome
Carney Complex, Type 1	Lamb Syndrome
Name Syndrome	Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome
Carney Complex - Trismus - Pseudocamptodactyly Syndrome	Carney Complex, Type 2
Car	Cnc1
Carney Myxoma-Endocrine Complex	Myxoma - Spotty Pigmentation - Endocrine Overactivity
Myxoma, Spotty Pigmentation, And Endocrine Overactivity	Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome
Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome	Carney Complex-Trismus-Pseudocamptodactyly Syndrome
CACOV

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni	Sbla Syndrome
LFS	Li-Fraumeni Familiar Cancer Susceptibility Syndrome
Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome	Lfs1
Li Fraumeni Syndrome	Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome
Lfl	Sbla Syndrome Li-Fraumeni-Like Syndrome
Li-Fraumeni Syndrome 1

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16185	ZNRF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZNRF3	VGNC	VGNC:67372
Macaca mulatta	ZNRF3	VGNC	VGNC:79114
Canis familiaris	ZNRF3	VGNC	VGNC:48840
Mus musculus	ZNRF3	MGD	MGI:3039616
Rattus norvegicus	ZNRF3	RGD	RGD:1593771
Bos taurus	ZNRF3	VGNC	VGNC:55766
Others	ZNRF3	NCBI

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