CARD11 - caspase recruitment domain family member 11 Gene

Homo sapiens

Also known as PPBL; BENTA; BIMP3; IMD11; CARMA1; IMD11A

Gene ID: 84433 | Gene type: protein coding

About CARD11

Cytogenetic location: 7p22.2 Genomic coordinates (GRCh38): 7:2,906,142-3,043,867 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 133 phenotypes. Biased expression in lymph node (RPKM 19.0), spleen (RPKM 15.1) and 10 other tissues.

Summary

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell Apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]

CARD11 Products(2)

mRNA	Protein	Name
NM_001324281.3	NP_001311210.1	caspase recruitment domain-containing protein 11
NM_032415.7	NP_115791.3	caspase recruitment domain-containing protein 11

CARD11 Protein Structure

CARD

0
200
400
600
800
1000
1154 a.a.

Protein Preferred Names

Protein Names

caspase recruitment domain-containing protein 11

CARD-containing MAGUK protein 1

Related Diseases

Diseases

Alias

B-Cell Expansion With Nfkb And T-Cell Anergy

Benta Disease	BENTA
B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease	Persistent Polyclonal B-Cell Lymphocytosis
Lymphocytosis

Immunodeficiency 11

Immunodeficiency 11a	Severe Combined Immunodeficiency Due To Card11 Deficiency
IMD11A	Imd11
Card11 Immunodeficiency	Scid Due To Card11 Deficiency
Card11 Deficiency	Immunodeficiency 11 A

Immunodeficiency 11b With Atopic Dermatitis

IMD11B	Atopic Dermatitis, Elevated Ige, And Eosinophilia
Immunodeficiency 11b

Splenomegaly

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Persistent Polyclonal B-Cell Lymphocytosis

PPBL	Persistent Polyclonal B-Cell Lymphocytosis With Binucleated Lymphocytes
Lymphocytosis, B-Cell, Polyclonal, Persistent

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum	Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis
Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Colon Squamous Cell Carcinoma

Colonic Epidermoid Carcinoma	Squamous Cell Carcinoma Of Colon
Squamous Cell Carcinoma Of The Colon

Marginal Zone B-Cell Lymphoma

Marginal Zone Lymphoma	Mzl
Mucosa-Associated Lymphoid Tissue Lymphoma

Central Nervous System Lymphoma

Microglioma	Primary Cns Lymphoma
Cns Lymphoma	Primary Central Nervous System Lymphoma

Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor	Hematopoietic Neoplasm Of Central Nervous System
Central Nervous System Hematopoietic Neoplasm

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

St2 Diffuse Large B-Cell Lymphoma

St2 Dlbcl

Doid:0081068

Testicular Lymphoma

Malignant Lymphoma Of Testis

Lymphoma Of The Testis

Spleen Cancer

Spleen Neoplasm	Splenic Neoplasm
Splenic Neoplasms	Malignant Splenic Tumor
Malignant Tumour Of Spleen	Tumor Of Spleen
Malignant Neoplasm Of Spleen

T-Cell Adult Acute Lymphocytic Leukemia

Acute Adult T-Cell Leukemia-Lymphoma	Adult Precursor T Lymphoblastic Leukemia
Atll	T-Cell Adult Acute Lymphoblastic Leukemia

Splenic Marginal Zone Lymphoma

Smzl	Splenic Marginal Zone B-Cell Lymphoma

Lymphoplasmacytic Lymphoma

Waldenstrom Macroglobulinemia	Malignant Lymphoma - Lymphoplasmacytic
Waldenström Macroglobulinaemia	Waldenström Macroglobulinaemia Without Mention Of Remission
Idiopathic Macroglobulinaemia	Primary Macroglobulinaemia

Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065

Immunodeficiency 58

IMD58	Severe Combined Immunodeficiency Due To Carmil2 Deficiency
Combined Immunodeficiency Due To Carmil2 Deficiency	Combined Immunodeficiency Due To Rltpr Deficiency

Ras-Associated Autoimmune Leukoproliferative Disorder

RALD	Autoimmune Lymphoproliferative Syndrome Type 4
Alps4	Autoimmune Lymphoproliferative Syndrome, Type Iv
Ras-Associated Autoimmune Leukoproliferative Disease	Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic
Alps Type 4	Alps Type Iv
Autoimmune Lymphoproliferative Syndrome Type Iv	Autoimmune Lymphoproliferative Syndrome 4

Pityriasis Rubra Pilaris

PRP	Devergie'S Disease
Prp - [Pityriasis Rubra Pilaris]

Adult T-Cell Leukemia/Lymphoma

Adult T-Cell Leukemia	Atll
Adult T-Cell Leukaemia	Adult T-Cell Leukaemia/Lymphoma
Adult T-Cell Lymphoma	T Cell Leukemia Lymphoma Adult
Leukemia-Lymphoma, Adult T-Cell	Leukemia, T-Cell
Adult T-Cell Lymphoma/Leukemia

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142648A	(R)-MLT-985	Inhibitor	/	Unkown
HY-RS01916	CARD11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CARD11	RGD	RGD:2323211
Macaca mulatta	CARD11	VGNC	VGNC:70568
Felis catus	CARD11	VGNC	VGNC:60364
Bos taurus	CARD11	VGNC	VGNC:26761
Mus musculus	CARD11	MGD	MGI:1916978
Canis familiaris	CARD11	VGNC	VGNC:38714
Others	CARD11	NCBI