Fgfr3 - fibroblast growth factor receptor 3 Gene

Rattus norvegicus

Gene ID: 84489 | Gene type: protein coding

About Fgfr3

Primary_assembly 14: 76,987,993-77,003,341 reverse strand.mRatBN7.2:CM026987.1

This gene has 3 transcripts (splice variants), 191 orthologues, 54 paralogues and is associated with 74 phenotypes. Biased expression in Lung (RPKM 455.3), Brain (RPKM 133.8) and 5 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity and fibroblast growth factor-activated receptor activity. Involved in cell-cell signaling; Fibroblast Growth Factor receptor signaling pathway; and positive regulation of cell population proliferation. Located in cell surface; cytoplasm; and nucleus. Biomarker of chondrosarcoma. Human ortholog(s) of this gene implicated in several diseases, including Crouzon syndrome-acanthosis nigricans syndrome; LADD syndrome; SADDAN; bone development disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (Fibroblast Growth Factor receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr3 Products(1)

mRNA	Protein	Name
NM_053429.2	NP_445881.2	fibroblast growth factor receptor 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	15231666	RGD
enables fibroblast growth factor receptor activity	IDA IDA: Inferred from direct assay	15231666	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	15231666	RGD
involved in fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15231666	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15231666	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15614790	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr3 Protein Structure

Ig_3

IgI_2_FGFR

IgI_3_FGFR

PTKc_FGFR3

0
200
400
600
804 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor receptor 3

Related Agents

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10981	Lenvatinib	Inhibitor	99.75%	Yes
HY-50904	Nintedanib	Inhibitor	99.94%	Yes
HY-18708	Erdafitinib	Inhibitor	99.66%	Unkown
HY-13311	Infigratinib	Inhibitor	99.72%	Yes
HY-109099	Pemigatinib	Inhibitor	99.84%	Yes
HY-100818	Futibatinib	Inhibitor	99.65%	Unkown
HY-11106	Nintedanib esylate	Inhibitor	99.95%	Yes
HY-10981A	Lenvatinib mesylate	Inhibitor	99.86%	Yes
HY-13311A	Infigratinib phosphate	Inhibitor	99.74%	Yes

Clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13330	Fexagratinib	Inhibitor	99.85%	Phase 3
HY-50905	Dovitinib	Inhibitor	99.88%	Phase 3
HY-100019	Rogaratinib	Inhibitor	99.86%	Phase 3
HY-10207	Dovitinib lactate	Inhibitor	99.75%	Phase 3
HY-B0062	Dovitinib lactate hydrate	Inhibitor	/	Phase 3
HY-101568	Roblitinib	Inhibitor	99.74%	Phase 2
HY-13034	Gandotinib	Inhibitor	99.82%	Phase 2
HY-19981	Derazantinib	Inhibitor	99.28%	Phase 2
HY-19957	Zoligratinib	Inhibitor	99.76%	Phase 2
HY-101466A	E7090 succinate	Inhibitor	99.17%	Phase 2
HY-13304	LY2874455	Inhibitor	98.03%	Phase 1
HY-10032	PF 477736	Inhibitor	99.21%	Phase 1
HY-119367	ODM-203	Inhibitor	99.91%	Phase 1
HY-101768	PRN1371	Inhibitor	99.43%	Phase 1
HY-19983	ASP5878	Inhibitor	99.69%	Phase 1
HY-100491	H3B-6527	Inhibitor	≥98.0%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99384	Vofatamab	Inhibitor	95.00%	Phase 2
HY-P99823	Recifercept		97.10%	Phase 2

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12823	BLU9931	Inhibitor	99.97%	Unkown
HY-18602	FIIN-2	Inhibitor	99.32%	Unkown
HY-15599	SSR128129E	Inhibitor	99.85%	Unkown
HY-145231	FGFR2-IN-2	Inhibitor	98.25%	Unkown
HY-148779	FGFR3-IN-5	Inhibitor	99.28%	Unkown
HY-101466	E7090	Inhibitor	99.64%	Unkown
HY-131908	CPL304110	Inhibitor	99.85%	Unkown
HY-15813	FIIN-1	Inhibitor	99.11%	Unkown
HY-18603	FIIN-3	Inhibitor	99.66%	Unkown
HY-P3695	VSPPLTLGQLLS	Inhibitor	98.08%	Unkown
HY-12965	S49076	Inhibitor	99.44%	Unkown
HY-108933	JK-P3	Inhibitor	99.72%	Unkown
HY-148778	FGFR3-IN-4	Inhibitor	/	Unkown
HY-156790	FGFR3-IN-6	Inhibitor	/	Unkown
HY-147714	FGFR3-IN-2	Inhibitor	/	Unkown
HY-151903S	FGFR2/3-IN-1	Inhibitor	/	Unkown
HY-156791	FGFR3-IN-7	Inhibitor	/	Unkown
HY-142921	FGFR-IN-2	Inhibitor	/	Unkown
HY-P3695A	VSPPLTLGQLLS TFA	Inhibitor	/	Unkown
HY-155028	FGFR-IN-11	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-150652	FGFR-IN-8	Inhibitor	/	Unkown
HY-152104	FGFR-IN-9	Inhibitor	/	Unkown
HY-147713	FGFR3-IN-1	Inhibitor	/	Unkown
HY-158248	FGFR4-IN-19	Inhibitor	/	Unkown
HY-147715	FGFR3-IN-3	Inhibitor	/	Unkown
HY-164459	AZ8010	Inhibitor	/	Unkown
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	Unkown
HY-15599A	SSR128129E free acid	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr3	NCBI	NCBI:2261
Mus musculus	Fgfr3	NCBI	NCBI:14184

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