FOXN1 - forkhead box N1 Gene

Homo sapiens

Also known as WHN; RONU; TLIND; FKHL20; TIDAND

Gene ID: 8456 | Gene type: protein coding

About FOXN1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,506,348-28,538,900 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues, 42 paralogues and is associated with 4 phenotypes. Biased expression in skin (RPKM 9.7) and esophagus (RPKM 2.5).

Summary

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]

FOXN1 Products(2)

mRNA	Protein	Name
NM_001369369.1	NP_001356298.1	forkhead box protein N1
NM_003593.3	NP_003584.2	forkhead box protein N1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	24383669	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXN1 Protein Structure

Forkhead

0
100
200
300
400
500
600
648 a.a.

Protein Preferred Names

Protein Names

forkhead box protein N1

Rowett nude

FOXN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOXN1	O15353	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	FOXN1	O15353	SPATC1L	Homo sapiens	Q9H0A9-2	Validated Y2H	32296183
Intra	FOXN1	O15353	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	FOXN1	O15353	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	32296183
Intra	FOXN1	O15353	TSSK1B	Homo sapiens	Q9BXA7	MAPPIT	32296183
Intra	FOXN1	O15353	TSSK1B	Homo sapiens	Q9BXA7	Validated Y2H	32296183
Intra	FOXN1	O15353	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	FOXN1	O15353	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	FOXN1	O15353	TRAPPC6A	Homo sapiens	O75865-2	Validated Y2H	32296183
Intra	FOXN1	O15353	LHX8	Homo sapiens	Q68G74	Validated Y2H	32296183
Intra	FOXN1	O15353	CDA	Homo sapiens	P32320	Validated Y2H	32296183
Intra	FOXN1	O15353	MAPKBP1	Homo sapiens	O60336	Validated Y2H	32296183
Intra	FOXN1	O15353	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy

Winged Helix Deficiency	Alymphoid Cystic Thymic Dysgenesis
Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome	Pignata Guarino Syndrome
TIDAND	T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy
Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency	Severe Combined Immunodeficiency Due To Foxn1 Deficiency
Foxn1 Deficiency	Nude/Scid
Nude/Severe Combined Immunodeficiency	Scid Due To Foxn1 Deficiency
Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy

T-Cell Lymphopenia, Infantile, With Or Without Nail Dystrophy, Autosomal Dominant

TLIND

T-Cell Lymphopenia, Infantile, Without Nail Dystrophy, Autosomal Dominant

T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome	T-Lymphocyte Deficiency
TIDTA	Immune Defect Due To Absence Of Thymus
Thymic Aplasia	Nezelof'S Syndrome
Thymic Dysplasia With Normal Immunoglobulins	Thymic Aplasia Syndrome
T-Lymphocyte Immunodeficiency

Alopecia

Lymphopenia

Lymphocytopenia

Ectopic Thymus

Thymus Squamous Cell Carcinoma

Epidermoid Thymic Carcinoma

Thymic Squamous Cell Carcinoma

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Thymic Dysplasia

Disseminated Chorioretinitis

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

T Cell Deficiency

T Cell Immunodeficiency	T Lymphocyte Deficiency
T Lymphocyte Immunodeficiency	T-Lymphocyte Deficiency

Fraser Syndrome 1

Fraser Syndrome	Cryptophthalmos With Other Malformations
Cryptophthalmos Syndrome	FRASRS1
Cryptophthalmos-Syndactyly Syndrome	Fraser-Francois Syndrome
Cyclopism	Meyer-Schwickerath'S Syndrome
Ulrich-Feichtiger Syndrome	Cryptophthalmos Syndactyly Syndrome
Fraser'S Syndrome	Meyer-Schwickerath Syndrome
Ullrich-Feichtiger Syndrome

Ectodermal Dysplasia 9, Hair/Nail Type

ECTD9	Ectodermal Dysplasia 9
Dysplasia, Ectodermal, Type 9, Hair/Nail

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Alopecia Universalis Congenita

Alopecia Universalis	ALUNC
Atrichia, Generalized	Au
Alopecia Areata Universalis	Atrichia Generalized

Atrichia With Papular Lesions

Papular Atrichia	APL
Congenital Atrichia

Ectodermal Dysplasia 5, Hair/Nail Type

ECTD5

Ectodermal Dysplasia 5

Ectodermal Dysplasia 6, Hair/Nail Type

ECTD6

Ectodermal Dysplasia 6

Ectodermal Dysplasia 7, Hair/Nail Type

ECTD7	Ectodermal Dysplasia 7
Dysplasia, Ectodermal, Type 7, Hair/Nail

Hair Disease

Hair Diseases	Hair Anomaly
Hair Disorder	Hair Problems

Ectodermal Dysplasia 4, Hair/Nail Type

Pure Hair And Nail Ectodermal Dysplasia	ECTD4
Ectodermal Dysplasia, Pure Hair-Nail Type	Ectodermal Dysplasia, 'Pure' Hair/Nail Type
Hned	Hair-Nail Ectodermal Dysplasia
Phned	Ectodermal Dysplasia Pure Hair-Nail Type
Ectodermal Dysplasia, 'Pure' Hair-Nail Type	Dysplasia, Ectodermal, Type 4, Hair/Nail

Keratosis, Seborrheic

Seborrheic Keratosis	Keratosis, Seborrheic, Somatic
Basal Cell Papilloma	Keratosis Seborrheica
KERSEB

Hypotrichosis 2

HYPT2	Hypotrichosis Simplex Of The Scalp 1
Htss1	Htss
Hypotrichosis, Spanish Type	Spanish Type Hypotrichosis
Hypotrichosis Spanish Type	Hypotrichosis, Type 2
Hypotrichosis Simplex Of Scalp

Acanthoma

Cutaneous Ganglioneuroma

Ganglioneuroma Of Skin

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Monilethrix

Beaded Hair	MNLIX
Nodose Hair	Moniliform Hair Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05065	FOXN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FOXN1	VGNC	VGNC:40960
Bos taurus	FOXN1	VGNC	VGNC:29095
Macaca mulatta	FOXN1	VGNC	VGNC:72481
Mus musculus	FOXN1	MGD	MGI:102949
Felis catus	FOXN1	VGNC	VGNC:62340
Rattus norvegicus	FOXN1	RGD	RGD:3970

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