1. Gene
  2. DMRT3 - doublesex and mab-3 related transcription factor 3 Gene

DMRT3 - doublesex and mab-3 related transcription factor 3 Gene

Homo sapiens

Also known as DMRTA3

Gene ID: 58524 | Gene type: protein coding

About DMRT3

Cytogenetic location: 9p24.3 Genomic coordinates (GRCh38): 9:976,655-991,732 (from NCBI)

This gene has 2 transcripts (splice variants), 190 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in thyroid (RPKM 4.6), testis (RPKM 2.6) and 2 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in male sex differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult walking behavior; transmission of nerve impulse; and ventral spinal cord interneuron specification. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DMRT3 Products(1)

mRNA Protein Name
NM_021240.4 NP_067063.1 doublesex- and mab-3-related transcription factor 3
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DMRT3 Protein Structure

DM

DM: DM DNA binding domain (25 - 71)

DMA

DMA: DMRTA motif (248 - 286)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

doublesex- and mab-3-related transcription factor 3

DMRT-like family A3

DMRT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DMRT3 Q9NQL9 KRT40 Homo sapiens Q6A162 32296183
Intra
DMRT3 Q9NQL9 KRT40 Homo sapiens Q6A162 25416956
Intra
DMRT3 Q9NQL9 KRT40 Homo sapiens Q6A162 25416956
Intra
DMRT3 Q9NQL9 KRT40 Homo sapiens Q6A162 32296183
Intra
DMRT3 Q9NQL9 KRTAP10-8 Homo sapiens P60410 25416956
Intra
DMRT3 Q9NQL9 KRTAP10-8 Homo sapiens P60410 32296183
Intra
DMRT3 Q9NQL9 KRTAP10-8 Homo sapiens P60410 32296183
Intra
DMRT3 Q9NQL9 KRTAP10-8 Homo sapiens P60410 25416956
Intra
DMRT3 Q9NQL9 KRTAP10-8 Homo sapiens P60410 25416956
Intra
DMRT3 Q9NQL9 KRTAP10-9 Homo sapiens P60411 32296183
Intra
DMRT3 Q9NQL9 KRTAP10-9 Homo sapiens P60411 32296183
Intra
DMRT3 Q9NQL9 KRTAP10-9 Homo sapiens P60411 25416956
Intra
DMRT3 Q9NQL9 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
DMRT3 Q9NQL9 MID2 Homo sapiens Q9UJV3-2 25416956
Intra
DMRT3 Q9NQL9 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
DMRT3 Q9NQL9 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
DMRT3 Q9NQL9 GPSM1 Homo sapiens Q86YR5-3 32296183
Intra
DMRT3 Q9NQL9 GPSM1 Homo sapiens Q86YR5-3 32296183
Intra
DMRT3 Q9NQL9 NFKBID Homo sapiens Q8NI38 32296183
Intra
DMRT3 Q9NQL9 NFKBID Homo sapiens Q8NI38 32296183
Intra
DMRT3 Q9NQL9 KRTAP9-3 Homo sapiens Q9BYQ3 32296183
Intra
DMRT3 Q9NQL9 KRTAP9-3 Homo sapiens Q9BYQ3 32296183
Intra
DMRT3 Q9NQL9 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
Intra
DMRT3 Q9NQL9 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
Intra
DMRT3 Q9NQL9 KRT34 Homo sapiens O76011 32296183
Intra
DMRT3 Q9NQL9 KRT34 Homo sapiens O76011 32296183
Intra
DMRT3 Q9NQL9 KRT38 Homo sapiens O76015 32296183
Intra
DMRT3 Q9NQL9 KRT38 Homo sapiens O76015 32296183
Intra
DMRT3 Q9NQL9 KRTAP19-5 Homo sapiens Q3LI72 32296183
Intra
DMRT3 Q9NQL9 KRTAP19-5 Homo sapiens Q3LI72 32296183
Intra
DMRT3 Q9NQL9 KRT35 Homo sapiens Q92764 32296183
Intra
DMRT3 Q9NQL9 KRT35 Homo sapiens Q92764 32296183
Intra
DMRT3 Q9NQL9 REL Homo sapiens Q04864-2 32296183
Intra
DMRT3 Q9NQL9 REL Homo sapiens Q04864-2 32296183
Intra
DMRT3 Q9NQL9 KPRP Homo sapiens Q5T749 32296183
Intra
DMRT3 Q9NQL9 KPRP Homo sapiens Q5T749 32296183
Intra
DMRT3 Q9NQL9 FOXN1 Homo sapiens O15353 32296183
Intra
DMRT3 Q9NQL9 FOXN1 Homo sapiens O15353 32296183
Intra
DMRT3 Q9NQL9 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
DMRT3 Q9NQL9 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-5 Homo sapiens Q9BYS1 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-5 Homo sapiens Q9BYS1 32296183
Intra
DMRT3 Q9NQL9 TLE5 Homo sapiens Q08117-2 32296183
Intra
DMRT3 Q9NQL9 TLE5 Homo sapiens Q08117-2 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-3 Homo sapiens Q8IUG1 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-3 Homo sapiens Q8IUG1 32296183
Intra
DMRT3 Q9NQL9 ATN1 Homo sapiens Q86V38 32296183
Intra
DMRT3 Q9NQL9 ATN1 Homo sapiens Q86V38 32296183
Intra
DMRT3 Q9NQL9 KRT36 Homo sapiens O76013-2 32296183
Intra
DMRT3 Q9NQL9 KRT36 Homo sapiens O76013-2 32296183
Intra
DMRT3 Q9NQL9 SPAG8 Homo sapiens Q99932-2 32296183
Intra
DMRT3 Q9NQL9 SPAG8 Homo sapiens Q99932-2 32296183
Intra
DMRT3 Q9NQL9 LMO2 Homo sapiens P25791-3 32296183
Intra
DMRT3 Q9NQL9 LMO2 Homo sapiens P25791-3 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-1 Homo sapiens Q07627 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-1 Homo sapiens Q07627 32296183
Intra
DMRT3 Q9NQL9 KRTAP6-2 Homo sapiens Q3LI66 32296183
Intra
DMRT3 Q9NQL9 KRTAP6-2 Homo sapiens Q3LI66 32296183
Intra
DMRT3 Q9NQL9 ZNF438 Homo sapiens Q7Z4V0 32296183
Intra
DMRT3 Q9NQL9 ZNF438 Homo sapiens Q7Z4V0 32296183
Intra
DMRT3 Q9NQL9 USP54 Homo sapiens Q70EL1-9 32296183
Intra
DMRT3 Q9NQL9 USP54 Homo sapiens Q70EL1-9 32296183
Intra
DMRT3 Q9NQL9 KRTAP5-7 Homo sapiens Q6L8G8 32296183
Intra
DMRT3 Q9NQL9 KRTAP5-7 Homo sapiens Q6L8G8 32296183
Intra
DMRT3 Q9NQL9 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
DMRT3 Q9NQL9 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
DMRT3 Q9NQL9 WWOX Homo sapiens Q9NZC7-5 32296183
Intra
DMRT3 Q9NQL9 WWOX Homo sapiens Q9NZC7-5 32296183
Intra
DMRT3 Q9NQL9 WWOX Homo sapiens Q9NZC7-5 32296183
Intra
DMRT3 Q9NQL9 ZFY Homo sapiens P08048 32296183
Intra
DMRT3 Q9NQL9 ZFY Homo sapiens P08048 32296183
Intra
DMRT3 Q9NQL9 PRR20D Homo sapiens P86480 32296183
Intra
DMRT3 Q9NQL9 PRR20D Homo sapiens P86480 32296183
Intra
DMRT3 Q9NQL9 TSC1 Homo sapiens Q86WV8 32296183
Intra
DMRT3 Q9NQL9 TSC1 Homo sapiens Q86WV8 32296183
Intra
DMRT3 Q9NQL9 NHLRC4 Homo sapiens P0CG21 32296183
Intra
DMRT3 Q9NQL9 NHLRC4 Homo sapiens P0CG21 32296183
Intra
DMRT3 Q9NQL9 UBASH3B Homo sapiens Q8TF42 25416956
Intra
DMRT3 Q9NQL9 UBASH3B Homo sapiens Q8TF42 25416956
Intra
DMRT3 Q9NQL9 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
DMRT3 Q9NQL9 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
DMRT3 Q9NQL9 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
DMRT3 Q9NQL9 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
DMRT3 Q9NQL9 ASPG Homo sapiens Q86U10 32296183
Intra
DMRT3 Q9NQL9 ASPG Homo sapiens Q86U10 32296183
Intra
DMRT3 Q9NQL9 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
DMRT3 Q9NQL9 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
DMRT3 Q9NQL9 KRTAP6-3 Homo sapiens Q3LI67 32296183
Intra
DMRT3 Q9NQL9 KRTAP6-3 Homo sapiens Q3LI67 32296183
Intra
DMRT3 Q9NQL9 REL Homo sapiens Q04864 25416956
Intra
DMRT3 Q9NQL9 PSMA3 Homo sapiens P25788 25416956
Intra
DMRT3 Q9NQL9 PSME3 Homo sapiens P61289 32296183
Intra
DMRT3 Q9NQL9 PSME3 Homo sapiens P61289 32296183
Intra
DMRT3 Q9NQL9 PFDN5 Homo sapiens Q99471 32296183
Intra
DMRT3 Q9NQL9 PFDN5 Homo sapiens Q99471 32296183
Intra
DMRT3 Q9NQL9 AKAP8L Homo sapiens Q9ULX6 32296183
Intra
DMRT3 Q9NQL9 AKAP8L Homo sapiens Q9ULX6 32296183
Intra
DMRT3 Q9NQL9 AKAP8L Homo sapiens Q9ULX6 32296183
Intra
DMRT3 Q9NQL9 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
DMRT3 Q9NQL9 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
DMRT3 Q9NQL9 KRTAP3-3 Homo sapiens Q9BYR6 32296183
Intra
DMRT3 Q9NQL9 KRTAP3-3 Homo sapiens Q9BYR6 32296183
Intra
DMRT3 Q9NQL9 PRDM14 Homo sapiens Q9GZV8 32296183
Intra
DMRT3 Q9NQL9 PRDM14 Homo sapiens Q9GZV8 32296183
Intra
DMRT3 Q9NQL9 KRTAP5-9 Homo sapiens P26371 25416956
Intra
DMRT3 Q9NQL9 TCF4 Homo sapiens P15884 25416956
Intra
DMRT3 Q9NQL9 OIP5 Homo sapiens O43482 32296183
Intra
DMRT3 Q9NQL9 OIP5 Homo sapiens O43482 32296183
Intra
DMRT3 Q9NQL9 MYOZ3 Homo sapiens Q8TDC0 32296183
Intra
DMRT3 Q9NQL9 MYOZ3 Homo sapiens Q8TDC0 32296183
Intra
DMRT3 Q9NQL9 RUSC1 Homo sapiens Q9BVN2 32296183
Intra
DMRT3 Q9NQL9 RUSC1 Homo sapiens Q9BVN2 32296183
Intra
DMRT3 Q9NQL9 INCA1 Homo sapiens Q0VD86 32296183
Intra
DMRT3 Q9NQL9 INCA1 Homo sapiens Q0VD86 25416956
Intra
DMRT3 Q9NQL9 INCA1 Homo sapiens Q0VD86 32296183
Intra
DMRT3 Q9NQL9 INCA1 Homo sapiens Q0VD86 25416956
Intra
DMRT3 Q9NQL9 SAT1 Homo sapiens P21673 25416956
Intra
DMRT3 Q9NQL9 SAT1 Homo sapiens P21673 25416956
Intra
DMRT3 Q9NQL9 HSF2BP Homo sapiens O75031 32296183
Intra
DMRT3 Q9NQL9 HSF2BP Homo sapiens O75031 32296183
Intra
DMRT3 Q9NQL9 CFAP68 Homo sapiens Q9H5F2 32296183
Intra
DMRT3 Q9NQL9 CFAP68 Homo sapiens Q9H5F2 32296183
Intra
DMRT3 Q9NQL9 TRIM27 Homo sapiens P14373 25416956
Intra
DMRT3 Q9NQL9 TRIM27 Homo sapiens P14373 25416956
Intra
DMRT3 Q9NQL9 TRIM27 Homo sapiens P14373 32296183
Intra
DMRT3 Q9NQL9 TRIM27 Homo sapiens P14373 32296183
Intra
DMRT3 Q9NQL9 KHDRBS3 Homo sapiens O75525 25416956
Intra
DMRT3 Q9NQL9 MDFI Homo sapiens Q99750 25416956
Intra
DMRT3 Q9NQL9 MDFI Homo sapiens Q99750 32296183
Intra
DMRT3 Q9NQL9 MDFI Homo sapiens Q99750 25416956
Intra
DMRT3 Q9NQL9 MDFI Homo sapiens Q99750 32296183
Intra
DMRT3 Q9NQL9 FRS3 Homo sapiens O43559 32296183
Intra
DMRT3 Q9NQL9 FRS3 Homo sapiens O43559 32296183
Intra
DMRT3 Q9NQL9 PLSCR1 Homo sapiens O15162 25416956
Intra
DMRT3 Q9NQL9 TRIM23 Homo sapiens P36406 25416956
Intra
DMRT3 Q9NQL9 TRIM23 Homo sapiens P36406 25416956
Intra
DMRT3 Q9NQL9 TRIM23 Homo sapiens P36406 25416956
Intra
DMRT3 Q9NQL9 RBPMS Homo sapiens Q93062 25416956
Intra
DMRT3 Q9NQL9 RBPMS Homo sapiens Q93062 25416956
Intra
DMRT3 Q9NQL9 RBPMS Homo sapiens Q93062 25416956
Intra
DMRT3 Q9NQL9 FHL3 Homo sapiens Q13643 32296183
Intra
DMRT3 Q9NQL9 FHL3 Homo sapiens Q13643 32296183
Intra
DMRT3 Q9NQL9 TRIP6 Homo sapiens Q15654 25416956
Intra
DMRT3 Q9NQL9 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
DMRT3 Q9NQL9 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
DMRT3 Q9NQL9 MTUS2 Homo sapiens Q5JR59 25416956
Intra
DMRT3 Q9NQL9 MTUS2 Homo sapiens Q5JR59 25416956
Intra
DMRT3 Q9NQL9 RFX6 Homo sapiens Q8HWS3 32296183
Intra
DMRT3 Q9NQL9 RFX6 Homo sapiens Q8HWS3 32296183
Intra
DMRT3 Q9NQL9 GRN Homo sapiens P28799 32296183
Intra
DMRT3 Q9NQL9 GRN Homo sapiens P28799 32296183
Intra
DMRT3 Q9NQL9 CCNDBP1 Homo sapiens O95273 25416956
Intra
DMRT3 Q9NQL9 FHL5 Homo sapiens Q5TD97 32296183
Intra
DMRT3 Q9NQL9 FHL5 Homo sapiens Q5TD97 32296183
Intra
DMRT3 Q9NQL9 LASP1 Homo sapiens Q14847-2 32296183
Intra
DMRT3 Q9NQL9 LASP1 Homo sapiens Q14847-2 32296183
Intra
DMRT3 Q9NQL9 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
DMRT3 Q9NQL9 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
DMRT3 Q9NQL9 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
DMRT3 Q9NQL9 KRT31 Homo sapiens Q15323 25416956
Intra
DMRT3 Q9NQL9 KRT31 Homo sapiens Q15323 32296183
Intra
DMRT3 Q9NQL9 KRT31 Homo sapiens Q15323 32296183
Intra
DMRT3 Q9NQL9 ATP6V0D1 Homo sapiens P61421 32296183
Intra
DMRT3 Q9NQL9 ATP6V0D1 Homo sapiens P61421 32296183
Intra
DMRT3 Q9NQL9 KRTAP3-1 Homo sapiens Q9BYR8 32296183
Intra
DMRT3 Q9NQL9 KRTAP3-1 Homo sapiens Q9BYR8 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
46,Xy Partial Gonadal Dysgenesis

46,Xy Pgd

46,Xy Partial Testicular Dysgenesis

Gonadoblastoma

GBY

Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos

Spermatogenic Failure 8

SPGF8

Chromosome 9p Deletion Syndrome

Monosomy 9p

Monosomy 9p Syndrome

Alfi Syndrome

9p Syndrome

Chromosome 9p Deletion

9p Deletion

9p Monosomy

Deletion 9p

Partial Monosomy 9p

9p Deletion Syndrome

9p- Syndrome

Alfi'S Syndrome

Chromosome 9, Partial Trisomy 9p

Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

Spermatocytoma

Spermatocytic Seminoma

Croup

Acute Obstructive Laryngitis

Laryngotracheobronchitis

Acute Laryngotracheobronchitis

Croup Syndrome

Acute Laryngitis With Obstruction

Obstructive Laryngitis

Obstructive Laryngitis Nos

Obstructive Laryngotracheitis Nos

46,Xy Sex Reversal

Swyer Syndrome

Pure Gonadal Dysgenesis 46,Xy

Gonadal Dysgenesis, Xy Female Type

Gonadal Dysgenesis, 46,Xy

46,Xy Cgd

46,Xy Complete Gonadal Dysgenesis

46,Xy Pure Gonadal Dysgenesis

46 Xy Gonadal Dysgenesis

46, Xy Cgd

46, Xy Complete Gonadal Dysgenesis

46, Xy Pure Gonadal Dysgenesis

Xy Pure Gonadal Dysgenesis

Female With 46,Xy Karyotype

Xy Females

Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

Wagr Syndrome

11p Partial Monosomy Syndrome

Chromosome 11p13 Deletion Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome

11p Deletion Syndrome

Chromosome 11p Deletion Syndrome

Wagr Complex

Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome

Deletion 11p13

WAGR

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome

Chromosome 11p Deletion

11p Deletion

11p Monosomy

Deletion 11p

Monosomy 11p

Partial Monosomy 11p

Agr Triad

Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome

Wagr Contiguous Gene Syndrome

Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome

Del(11)(P13)

Monosomy 11p13

Chromosome 11, Deletion 11p

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DMRT3 RGD RGD:1306043
Bos taurus DMRT3 VGNC VGNC:28112
Felis catus DMRT3 VGNC VGNC:102919
Canis familiaris DMRT3 VGNC VGNC:49682
Mus musculus DMRT3 MGD MGI:2449470