SPINK7 - serine peptidase inhibitor Kazal type 7 Gene

Homo sapiens

Also known as ECG2; ECRG2

Gene ID: 84651 | Gene type: protein coding

About SPINK7

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:148,312,423-148,315,919 (from NCBI)

This gene has 6 transcripts (splice variants), 101 orthologues and 5 paralogues. Restricted expression toward esophagus (RPKM 102.7).

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

SPINK7 Products(1)

mRNA	Protein	Name
NM_032566.3	NP_115955.1	serine protease inhibitor Kazal-type 7 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12646258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPINK7 Protein Structure

Kazal_1

0
85 a.a.

Protein Preferred Names

Protein Names

serine protease inhibitor Kazal-type 7

ECRG-2

SPINK7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPINK7	P58062	q8izw4_human	Homo sapiens	Q8IZW4	Y2H	12970870
Intra	SPINK7	P58062	MT1G	Homo sapiens	P13640	Y2H	12970870
Intra	SPINK7	P58062	EPB42	Homo sapiens	P16452	Y2H	12646258
Intra	SPINK7	P58062	MT1H	Homo sapiens	P80294	Y2H	12970870
Intra	SPINK7	P58062	MT1H	Homo sapiens	P80294	Y2H	12646258
Intra	SPINK7	P58062	MRPS12	Homo sapiens	O15235	Y2H	12970870
Intra	SPINK7	P58062	RABL6	Homo sapiens	Q3YEC7	Y2H	12646258
Intra	SPINK7	P58062	RABL6	Homo sapiens	Q3YEC7	Y2H	12970870
Intra	SPINK7	P58062	MT2A	Homo sapiens	P02795	Y2H	12970870
Intra	SPINK7	P58062	MT2A	Homo sapiens	P02795	Confocal	12646258
Intra	SPINK7	P58062	MT2A	Homo sapiens	P02795	Pull Down	12646258

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPINK7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71331	SPINK7 Protein, Human (HEK293, His)	P58062 (S20-C85)	≥95%

Related Diseases

Diseases

Alias

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13684	SPINK7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SPINK7	RGD	RGD:1303077
Macaca mulatta	SPINK7	VGNC	VGNC:82545
Canis familiaris	SPINK7	VGNC	VGNC:103707
Felis catus	SPINK7	VGNC	VGNC:102330
Bos taurus	SPINK7	VGNC	VGNC:82546
Mus musculus	SPINK7	MGD	MGI:3644691
Others	SPINK7	NCBI

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