ACCS - 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Gene

Homo sapiens

Also known as ACS; PHACS

Gene ID: 84680 | Gene type: protein coding

About ACCS

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:44,066,270-44,084,237 (from NCBI)

This gene has 13 transcripts (splice variants), 149 orthologues and 7 paralogues. Ubiquitous expression in spleen (RPKM 11.2), gall bladder (RPKM 7.3) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]

ACCS Products(2)

mRNA	Protein	Name
NM_001127219.2	NP_001120691.1	1-aminocyclopropane-1-carboxylate synthase-like protein 1
NM_032592.4	NP_115981.1	1-aminocyclopropane-1-carboxylate synthase-like protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables 1-aminocyclopropane-1-carboxylate synthase activity	IDA IDA: Inferred from direct assay	11470512	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACCS Protein Structure

Aminotran_1_2

0
100
200
300
400
501 a.a.

Protein Preferred Names

Protein Names

1-aminocyclopropane-1-carboxylate synthase-like protein 1

ACC synthase-like protein 1

ACCS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ACCS	Q96QU6	UQCRB	Homo sapiens	P14927	Y2H Prey Pooling	25416956
Intra	ACCS	Q96QU6	ACCS	Homo sapiens	Q96QU6	Y2H Array	31515488
Intra	ACCS	Q96QU6	ACCS	Homo sapiens	Q96QU6	Y2H Prey Pooling	32296183
Intra	ACCS	Q96QU6	ACCS	Homo sapiens	Q96QU6-1	Y2H Array	31515488
Intra	ACCS	Q96QU6	ACCS	Homo sapiens	Q96QU6	Validated Y2H	32296183
Intra	ACCS	Q96QU6	ACCS	Homo sapiens	Q96QU6	Y2H Array	25416956
Intra	ACCS	Q96QU6	ACCS	Homo sapiens	Q96QU6	Y2H Array	32296183
Intra	ACCS	Q96QU6	ACCS	Homo sapiens	Q96QU6	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Thyroid Dyshormonogenesis 5

TDH5	Hypothyroidism, Congenital, Due To Dyshormonogenesis, 5
Thyroid Hormonogenesis, Genetic Defect In, 5	Genetic Defect In Thyroid Hormonogenesis 5
Chdh5	Congenital Hypothyroidism Due To Dyshormonogenesis Type 5
Genetic Defect In Thyroid Hormonogenesis Type 5

Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis	Acanthamoeba Encephalitis
Acanthamoeba Granulomatous Encephalitis	Granulomatous Amebic Encephalitis Due To Acanthamoeba

Twin-To-Twin Transfusion Syndrome

Twin To Twin Transfusion Syndrome	Twin Twin Transfusion Syndrome
Fetal Blood Loss From Fetal Hemorrhage Into Co-Twin	Fetal Hemorrhage Into Co-Twin
Twin To Twin Transfusion	Twin-To-Twin Blood Transfer
Fetal Transfusion Syndrome	Fetofetal Transfusion Syndrome
Ttts	Feto-Fetal Transfusion Syndrome
Fetofetal Transfusion	Fetus-To-Fetus Placental Transfusion Syndrome

Primary Amebic Meningoencephalitis

Pam	Naegleria Fowleri Infection
Meningoencephalitis Caused By Naegleria Fowleri	Primary Amoebic Meningoencephalitis

Thyroid Dyshormonogenesis 4

Deiodinase Deficiency	TDH4
Iodotyrosine Dehalogenase Deficiency	Thyroid Hormonogenesis, Genetic Defect In, 4
Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4	Genetic Defect In Thyroid Hormonogenesis 4
Chdh4	Congenital Hypothyroidism Due To Dyshormonogenesis Type 4
Genetic Defect In Thyroid Hormonogenesis Type 4

Aplasia Of Lacrimal And Salivary Glands

ALSG	Congenital Absence Of Lacrimal Puncta And Salivary Glands
Xerostomia	Absence Of Salivary Glands
Parotid Aplasia Or Hypoplasia	Congenital Absence Of Lacrimal Puncta Or Salivary Glands
Alsg - [Aplasia Of Lacrimal Or Salivary Glands]

Mucopolysaccharidosis, Type Ix

Mucopolysaccharidosis Type Ix	Hyaluronidase Deficiency
MPS9	Mps Ix
Mucopolysaccharidosis Ix	Mpsix
Mucopolysaccharidosis Type 9	Mucopolysaccharidosis 9

Neonatal Anemia

Anemia Neonatal	Anemia, Neonatal
Anaemia Neonatal	Neonatal Anaemia

Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17641	Olumacostat glasaretil	Inhibitor	98.90%	Phase 3
HY-16901	Firsocostat	Inhibitor	99.96%	Phase 2
HY-12942	PF-05175157	Inhibitor	98.46%	Phase 2
HY-153367	FHD-609	Inhibitor	99.15%	Phase 1
HY-135981	CMS-121	Inhibitor	99.63%	Phase 1
HY-107709	MK-4074	Inhibitor	99.04%	Phase 1
HY-102066	Utatrectinib	Inhibitor	98.72%	Phase 1

Pre-clinical Phase

Bioactive Molecules (33)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101842	ND-646	Inhibitor	99.13%	Unkown
HY-D0713	7ACC2	Inhibitor	99.62%	Unkown
HY-D0067	7ACC1	Inhibitor	99.71%	Unkown
HY-15259	CP-640186	Inhibitor	99.72%	Unkown
HY-12741	LDN-212320	Activator	99.09%	Unkown
HY-15259A	CP-640186 hydrochloride	Inhibitor	99.90%	Unkown
HY-147004	A-908292	Inhibitor	99.37%	Unkown
HY-152117	Acetyl-CoA Carboxylase-IN-1	Inhibitor	99.16%	Unkown
HY-100771	PCC0208009	Inhibitor	99.08%	Unkown
HY-E70227	Cathepsin G, human neutrophils		90.00%	Unkown
HY-144701	SABA1	Inhibitor	99.15%	Unkown
HY-120904	AMPK-IN-1	Activator	95.19%	Unkown
HY-16901A	Firsocostat (S enantiomer)		98.25%	Unkown
HY-16943	Moiramide B	Inhibitor	99.24%	Unkown
HY-19624	NVP-ACC789	Inhibitor	99.52%	Unkown
HY-P10002	EWFW-ACC		95.29%	Unkown
HY-P10003B	iso-VQA-ACC acetate		/	Unkown
HY-127128	Flestolol sulfate	Inhibitor	/	Unkown
HY-147376	hACC2-IN-1	Inhibitor	/	Unkown
HY-147930	ACC1/2-IN-1	Inhibitor	/	Unkown
HY-147932	ACC1/2-IN-2	Inhibitor	/	Unkown
HY-148684	AMPK activator 10	Activator	/	Unkown
HY-151931	JA-ACC		/	Unkown
HY-151931S	JA-ACC-d3		/	Unkown
HY-161976	ACC1-IN-2	Inhibitor	/	Unkown
HY-169008	PROTAC ACC degrader-1	Degrader	/	Unkown
HY-169009	(Rac)-Spirotetramat-enol		/	Unkown
HY-169010	Pomalidomide-CO-C5-Br		/	Unkown
HY-16946	CP-610431	Inhibitor	/	Unkown
HY-P10002A	EWFW-ACC TFA		/	Unkown
HY-P10003	iso-VQA-ACC		/	Unkown
HY-P10003A	iso-VQA-ACC TFA		/	Unkown
HY-RS00146	ACCS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ACCS	RGD	RGD:1309314
Mus musculus	ACCS	MGD	MGI:1919717

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