IRS4 - insulin receptor substrate 4 Gene

Homo sapiens

Also known as CHNG9; IRS-4; PY160

Gene ID: 8471 | Gene type: protein coding

About IRS4

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,719,946-108,736,563 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 85 phenotypes. Biased expression in ovary (RPKM 3.0), thyroid (RPKM 1.0) and 3 other tissues.

Summary

IRS4 encodes the Insulin Receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the Insulin Receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]

IRS4 Products(2)

mRNA	Protein	Name
NM_001379150.1	NP_001366079.1	insulin receptor substrate 4 isoform 2
NM_003604.2	NP_003595.1	insulin receptor substrate 4 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11316748	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRS4 Protein Structure

IRS

0
200
400
600
800
1000
1257 a.a.

Protein Preferred Names

Protein Names

insulin receptor substrate 4

160 kDa phosphotyrosine protein

Related Diseases

Diseases

Alias

Hypothyroidism, Congenital, Nongoitrous, 9

CHNG9	Congenital Nongoitrous Hypothyroidism 9
Hypothyroidism, Congenital, Non-Goitrous, 9	Hypothyroidism, Congenital, Nongoitrous, Type 9

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Hypothyroidism, Central, With Testicular Enlargement

X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement	CHTE
Hypothyroidism, Central, And Testicular Enlargement	Igsf1 Deficiency Syndrome
X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism	Central Hypothyroidism And Testicular Enlargement
Hypothyroidism, Central, Testicular Enlargement

Boutonneuse Fever

Mediterranean Spotted Fever	African Tick Typhus
Boutonneuse Disease	Conor And Bruch'S Disease
Kenya Fever	Kenya Tick Typhus
Kenyan Tick Typhus	Marseilles Fever
Mediterranean Tick Fever	Rickettsia Conorii Spotted Fever
South African Tick-Bite Fever	African Tick Bite Fever

Breast Rhabdomyosarcoma

Rhabdomyosarcoma Of The Breast

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06919	IRS4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRS4	MGD	MGI:1338009
Bos taurus	IRS4	VGNC	VGNC:30285
Macaca mulatta	IRS4	VGNC	VGNC:73767
Felis catus	IRS4	VGNC	VGNC:67831
Rattus norvegicus	IRS4	RGD	RGD:1562442
Canis familiaris	IRS4	VGNC	VGNC:42100

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