2. Gene
  3. CDC42BPA - CDC42 binding protein kinase alpha Gene

CDC42BPA - CDC42 binding protein kinase alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MRCK; MRCKA; PK428

Gene ID: 8476 | Gene type: protein coding

About CDC42BPA

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:226,989,858-227,318,492 (from NCBI)

This gene has 15 transcripts (splice variants), 234 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 11.8), kidney (RPKM 9.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]

CDC42BPA Products(7)

mRNA Protein Name
NM_001366010.2 NP_001352939.1 serine/threonine-protein kinase MRCK alpha isoform D
NM_001366011.1 NP_001352940.1 serine/threonine-protein kinase MRCK alpha isoform E
NM_001366019.2 NP_001352948.1 serine/threonine-protein kinase MRCK alpha isoform C
NM_001387550.1 NP_001374479.1 serine/threonine-protein kinase MRCK alpha isoform F
NM_001394014.1 NP_001380943.1 serine/threonine-protein kinase MRCK alpha isoform G
NM_003607.4 NP_003598.2 serine/threonine-protein kinase MRCK alpha isoform B
NM_014826.5 NP_055641.3 serine/threonine-protein kinase MRCK alpha isoform A

CDC42BPA Protein Structure

Pkinase

Pkinase: Protein kinase domain (77 - 343)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (361 - 406)

DMPK_coil

DMPK_coil: DMPK coiled coil domain like (881 - 941)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (1000 - 1050)

CNH

CNH: CNH domain (1220 - 1482)

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  • 1781 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase MRCK alpha

CDC42 binding protein kinase alpha (DMPK-like)

Related Diseases

Diseases Alias
Myotonic Dystrophy 1

Myotonic Dystrophy

Dystrophia Myotonica

Steinert Disease

Myotonic Dystrophy Type 1

Myotonia Atrophica

DM1

Congenital Myotonic Dystrophy

Myotonia Dystrophica

Steinert Myotonic Dystrophy

Dystrophia Myotonica 1

Dm

Steinert'S Disease

Steinert Myotonic Dystrophy Syndrome

Myotonic Dystrophy Of Steinert

Dystrophia Myotonica Type 1

Myotonic Dystrophy Congenital

Dystrophy, Myotonic, Type 1

Dm - [Dystrophia Myotonica]

Myotonic Muscular Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02301 CDC42BPA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDC42BPA VGNC VGNC:60657
Macaca mulatta CDC42BPA VGNC VGNC:70799
Rattus norvegicus CDC42BPA RGD RGD:621406
Canis familiaris CDC42BPA VGNC VGNC:38997
Mus musculus CDC42BPA MGD MGI:2441841
Bos taurus CDC42BPA VGNC VGNC:27069
Others CDC42BPA NCBI