RAB2B - RAB2B, member RAS oncogene family Gene

Homo sapiens

Gene ID: 84932 | Gene type: protein coding

About RAB2B

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,459,020-21,476,959 (from NCBI)

This gene has 6 transcripts (splice variants), 114 orthologues and 68 paralogues. Ubiquitous expression in bone marrow (RPKM 6.9), testis (RPKM 6.8) and 25 other tissues.

Summary

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]

RAB2B Products(2)

mRNA	Protein	Name
NM_001163380.2	NP_001156852.1	ras-related protein Rab-2B isoform 2
NM_032846.4	NP_116235.2	ras-related protein Rab-2B isoform 1

RAB2B Protein Structure

Ras

0
100
200
216 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-2B

GTP-binding protein RAB2B

RAB2B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB2B	Q8WUD1	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	25416956
Intra	RAB2B	Q8WUD1	ICA1	Homo sapiens	Q05084	Y2H Array	29892012
Intra	RAB2B	Q8WUD1	GDI2	Homo sapiens	P50395	Anti Tag CoIP	33961781
Intra	RAB2B	Q8WUD1	GDI2	Homo sapiens	P50395	Anti Tag CoIP	35271311
Intra	RAB2B	Q8WUD1	FAM114A2	Homo sapiens	Q9NRY5	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	FAM114A2	Homo sapiens	Q9NRY5	Validated Y2H	32296183
Intra	RAB2B	Q8WUD1	FAM114A2	Homo sapiens	Q9NRY5	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	TBX19	Homo sapiens	O60806	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	TBX19	Homo sapiens	O60806	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	VRTN	Homo sapiens	Q9H8Y1	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	VRTN	Homo sapiens	Q9H8Y1	Validated Y2H	32296183
Intra	RAB2B	Q8WUD1	VRTN	Homo sapiens	Q9H8Y1	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	GARIN1A	Homo sapiens	Q6NXP2-2	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	GARIN1A	Homo sapiens	Q6NXP2-2	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	GARIN4	Homo sapiens	Q8IYT1	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	GARIN4	Homo sapiens	Q8IYT1	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	RAB2B	Q8WUD1	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	25416956
Intra	RAB2B	Q8WUD1	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	FAM114A1	Homo sapiens	Q8IWE2	Validated Y2H	25416956
Intra	RAB2B	Q8WUD1	FAM114A1	Homo sapiens	Q8IWE2	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	FAM114A1	Homo sapiens	Q8IWE2	Anti Tag CoIP	33961781
Intra	RAB2B	Q8WUD1	FAM114A1	Homo sapiens	Q8IWE2	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	RAB2B	Q8WUD1	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	RAB2B	Q8WUD1	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	STAMBPL1	Homo sapiens	Q96FJ0	Validated Y2H	32296183
Intra	RAB2B	Q8WUD1	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	TXNDC11	Homo sapiens	Q6PKC3	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	TXNDC11	Homo sapiens	Q6PKC3	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	GARIN6	Homo sapiens	Q8NEG0	Y2H Array	25416956
Intra	RAB2B	Q8WUD1	GARIN6	Homo sapiens	Q8NEG0	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Carpenter Syndrome 1

Carpenter Syndrome	Acrocephalopolysyndactyly Type Ii
Acps Ii	CRPT1
Acrocephalopolysyndactyly Type 2	Acrocephalosyndactyly, Type Ii
Acrocephalopolysyndactyly 2	Acps2
Acps 2	Type Ii Acrocephalosyndactyly
Carpenter Syndrome, Type 1	Apert-Crouzon Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11542	RAB2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAB2B	MGD	MGI:1923588
Macaca mulatta	RAB2B	VGNC	VGNC:81530
Rattus norvegicus	RAB2B	RGD	RGD:1309117
Bos taurus	RAB2B	VGNC	VGNC:33638
Felis catus	RAB2B	VGNC	VGNC:97588
Canis familiaris	RAB2B	VGNC	VGNC:45272

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