CDK10 - cyclin dependent kinase 10 Gene

Homo sapiens

Also known as ALSAS; PISSLRE

Gene ID: 8558 | Gene type: protein coding

About CDK10

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,686,689-89,696,354 (from NCBI)

This gene has 22 transcripts (splice variants), 200 orthologues, 26 paralogues and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 16.8), thyroid (RPKM 15.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

CDK10 Products(4)

mRNA	Protein	Name
NM_001098533.3	NP_001092003.2	cyclin-dependent kinase 10 isoform c
NM_001160367.2	NP_001153839.1	cyclin-dependent kinase 10 isoform d
NM_052987.4	NP_443713.2	cyclin-dependent kinase 10 isoform b
NM_052988.5	NP_443714.3	cyclin-dependent kinase 10 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18242510	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	27104747	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	27104747	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	27104747	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	27104747	GOA
involved in regulation of cell cycle G2/M phase transition	IDA IDA: Inferred from direct assay	7664269	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	27104747	GOA
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: Inferred from physical interaction	24218572	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11006117	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK10 Protein Structure

Pkinase

0
100
200
300
360 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 10

CDC2-related protein kinase

Related Diseases

Diseases

Alias

Al Kaissi Syndrome

ALKAS

Growth Retardation, Spine Malformation, Dysmorphic Facies, And Developmental Delay

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Acromesomelic Dysplasia 2b

Fibular Hypoplasia And Complex Brachydactyly	Du Pan Syndrome
AMD2B	Dupans
Acromesomelic Dysplasia-2b	Fibular Aplasia-Complex Brachydactyly Syndrome

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02351	CDK10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDK10	RGD	RGD:1304851
Macaca mulatta	CDK10	VGNC	VGNC:99499
Canis familiaris	CDK10	VGNC	VGNC:39043
Bos taurus	CDK10	VGNC	VGNC:27116
Felis catus	CDK10	VGNC	VGNC:60693
Mus musculus	CDK10	MGD	MGI:2448549
Others	CDK10	NCBI

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