DENR - density regulated re-initiation and release factor Gene

Homo sapiens

Also known as DRP; DRP1; SMAP-3

Gene ID: 8562 | Gene type: protein coding

About DENR

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,752,824-122,771,064 (from NCBI)

This gene has 4 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in thyroid (RPKM 16.4), lymph node (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and Plants. [provided by RefSeq, Jul 2008]

DENR Products(1)

mRNA	Protein	Name
NM_003677.5	NP_003668.2	density-regulated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in IRES-dependent viral translational initiation	IDA IDA: Inferred from direct assay	20713520	GOA
involved in formation of translation preinitiation complex	IDA IDA: Inferred from direct assay	20713520	GOA
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	20713520	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	16982740	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DENR Protein Structure

SUI1

0
100
198 a.a.

Protein Preferred Names

Protein Names

density-regulated protein

smooth muscle cell associated protein-3

DENR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DENR	O43583	MARCHF5	Homo sapiens	Q9NX47	Anti Tag CoIP	16874301
Intra	DENR	O43583	MARCHF5	Homo sapiens	Q9NX47	Anti Tag CoIP	16936636
Intra	DENR	O43583	NELFB	Homo sapiens	Q8WX92	TAP	20195357
Intra	DENR	O43583	MCTS1	Homo sapiens	Q9ULC4	Validated Y2H	32296183
Intra	DENR	O43583	MCTS1	Homo sapiens	Q9ULC4	Y2H	21516116
Intra	DENR	O43583	MCTS1	Homo sapiens	Q9ULC4	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DENR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72172	DENR Protein, Human (His-SUMO)	O43583 (A2-K198)	≥95%

Related Diseases

Diseases

Alias

Capillary Malformations, Congenital

Familial Multiple Nevi Flammei	Nevi Flammei, Familial Multiple
CMC	Port-Wine Stain
Capillary Malformations	Cmal
Familial Multiple Port-Wine Stains	Capillary Malformation
Capillary Malformations, Congenital, 1, Somatic, Mosaic	Congenital Capillary Malformations
Port-Wine Stain Familial Multiple	Hereditary Capillary Malformations
Capillary Malformations, Hereditary	Capillary Malformations, Congenital, Type 1, Somatic, Mosaic
Strawberry Nevus Of Skin	Naevus Flammeus

Optic Nerve Disease

Optic Neuropathy	Disorder Of The Second Nerve
Optic Nerve Disorder	Optic Nerve
Abnormality Of The Optic Nerve	Optic Nerve Disorders
Neuropathy, Optic	Disorder Of The Optic Nerve

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03692	DENR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DENR	MGD	MGI:1915434
Canis familiaris	DENR	VGNC	VGNC:52927
Macaca mulatta	DENR	VGNC	VGNC:108337
Rattus norvegicus	DENR	RGD	RGD:1584200
Felis catus	DENR	VGNC	VGNC:80435
Others	DENR	NCBI

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