MCTS1 - MCTS1 re-initiation and release factor Gene

Homo sapiens

Also known as MCT1; MCT-1

Gene ID: 28985 | Gene type: protein coding

About MCTS1

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:120,604,101-120,621,159 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 206 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 3.6), brain (RPKM 3.4) and 25 other tissues.

Summary

Predicted to enable translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of translation preinitiation complex; and ribosome disassembly. Located in cytosol and plasma membrane. Colocalizes with cytosolic small ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]

MCTS1 Products(2)

mRNA	Protein	Name
NM_001137554.2	NP_001131026.1	malignant T-cell-amplified sequence 1 isoform 2
NM_014060.3	NP_054779.1	malignant T-cell-amplified sequence 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA cap binding	IDA IDA: Inferred from direct assay	16982740	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables ribosomal small subunit binding	IDA IDA: Inferred from direct assay	20713520	GOA
enables translation factor activity, non-nucleic acid binding	IDA IDA: Inferred from direct assay	20713520	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in IRES-dependent viral translational initiation	IDA IDA: Inferred from direct assay	20713520	GOA
involved in formation of translation preinitiation complex	IDA IDA: Inferred from direct assay	20713520	GOA
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	20713520	GOA
involved in ribosome disassembly	IMP IMP: Inferred from mutant phenotype	37875108	GOA
involved in translation reinitiation	IMP IMP: Inferred from mutant phenotype	37875108	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	16982740	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCTS1 Protein Structure

PUA

0
100
181 a.a.

Protein Preferred Names

Protein Names

malignant T-cell-amplified sequence 1

malignant T-cell amplified sequence 1

Related Diseases

Diseases

Alias

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1804	Tricaprilin		≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12750	AZD3965	Inhibitor	99.95%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13248	AR-C155858	Inhibitor	99.62%	Unkown
HY-N4115	Syrosingopine	Inhibitor	99.30%	Unkown
HY-139665	VB124	Inhibitor	99.86%	Unkown
HY-122312	BAY-8002	Inhibitor	98.39%	Unkown
HY-D0067	7ACC1	Inhibitor	99.96%	Unkown
HY-138559	GW604714X	Inhibitor	98.99%	Unkown
HY-18974	MCT1-IN-2	Inhibitor	99.16%	Unkown
HY-150314	MCT-IN-1	Inhibitor	≥98.0%	Unkown
HY-119996A	AR-C141990 hydrochloride	Inhibitor	≥98.0%	Unkown
HY-119996	AR-C141990		/	Unkown
HY-148574	MCT1-IN-3	Inhibitor	/	Unkown
HY-RS08251	MCTS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MCTS1	VGNC	VGNC:54172
Rattus norvegicus	MCTS1	RGD	RGD:1566390
Mus musculus	MCTS1	MGD	MGI:1916245
Macaca mulatta	MCTS1	VGNC	VGNC:74558
Bos taurus	MCTS1	VGNC	VGNC:56930

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