AKR7A3 - aldo-keto reductase family 7 member A3 Gene

Homo sapiens

Also known as AFAR2

Gene ID: 22977 | Gene type: protein coding

About AKR7A3

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,274,229-19,288,770 (from NCBI)

This gene has 1 transcript (splice variant), 490 orthologues and 16 paralogues. Biased expression in duodenum (RPKM 81.0), small intestine (RPKM 50.3) and 6 other tissues.

Summary

Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]

AKR7A3 Products(1)

mRNA	Protein	Name
NM_012067.3	NP_036199.2	aflatoxin B1 aldehyde reductase member 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR7A3 Protein Structure

Aldo_ket_red

0
100
200
300
331 a.a.

Protein Preferred Names

Protein Names

aflatoxin B1 aldehyde reductase member 3

AFB1 aldehyde reductase 2

AKR7A3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKR7A3	O95154	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	AKR7A3	O95154	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	AKR7A3	O95154	AKR7A2	Homo sapiens	O43488	Anti Tag CoIP	33961781
Intra	AKR7A3	O95154	AKR7A2	Homo sapiens	O43488	Anti Tag CoIP	28514442
Intra	AKR7A3	O95154	AKR7A2	Homo sapiens	O43488	Y2H Array	31515488
Intra	AKR7A3	O95154	AKR7A3	Homo sapiens	O95154	Y2H Array	32296183
Intra	AKR7A3	O95154	COMMD9	Homo sapiens	Q9P000	Anti Tag CoIP	33961781
Intra	AKR7A3	O95154	AKR7L	Homo sapiens	Q8NHP1	Anti Tag CoIP	33961781
Intra	AKR7A3	O95154	AKR7A3	Homo sapiens	O95154	Y2H Pooling	16189514
Intra	AKR7A3	O95154	COMMD9	Homo sapiens	Q9P000	Anti Tag CoIP	28514442
Intra	AKR7A3	O95154	AKR7A3	Homo sapiens	O95154	Y2H Prey Pooling	32296183
Intra	AKR7A3	O95154	AKR7L	Homo sapiens	Q8NHP1	Anti Tag CoIP	28514442
Intra	AKR7A3	O95154	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	AKR7A3	O95154	AKR7A3	Homo sapiens	O95154	Y2H Array	31515488
Intra	AKR7A3	O95154	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	AKR7A3	O95154	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	AKR7A3	O95154	AKR7A3	Homo sapiens	O95154	Validated Y2H	32296183
Intra	AKR7A3	O95154	AKR7A3	Homo sapiens	O95154	Y2H Array	25416956
Intra	AKR7A3	O95154	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
Intra	AKR7A3	O95154	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cytochrome P450 Oxidoreductase Deficiency

Por Deficiency	Pord
Antley-Bixler Syndrome With Disordered Steroidogenesis	Antley-Bixler Syndrome
Antley-Bixler Syndrome-Like Phenotype With Disordered Steroidogenesis	Combined Partial Deficiency Of 17-Hydroxylase And 21-Hydroxylase
Congenital Adrenal Hyperplasia Due To Apparent Combined P450c17 And P450c21 Deficiency	Antley-Bixler Syndrome, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00541	AKR7A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AKR7A3	MGD	MGI:107796
Rattus norvegicus	AKR7A3	RGD	RGD:628635

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