SCARF1 - scavenger receptor class F member 1 Gene

Homo sapiens

Also known as SREC; SREC1; SREC-I

Gene ID: 8578 | Gene type: protein coding

About SCARF1

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,633,858-1,645,732 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 190 orthologues and 3 paralogues. Broad expression in spleen (RPKM 18.4), lung (RPKM 9.9) and 22 other tissues.

Summary

The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

SCARF1 Products(2)

mRNA	Protein	Name
NM_003693.4	NP_003684.2	scavenger receptor class F member 1 isoform 1 precursor
NM_145350.3	NP_663325.1	scavenger receptor class F member 1 isoform 3 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables low-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	9395444	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables scavenger receptor activity	IDA IDA: Inferred from direct assay	9395444	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	9395444	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCARF1 Protein Structure

hEGF

Laminin_EGF

hEGF

0
200
400
600
830 a.a.

Protein Preferred Names

Protein Names

scavenger receptor class F member 1

acetyl LDL receptor

SCARF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCARF1	Q14162	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	SCARF1	Q14162	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	MRM3	Homo sapiens	Q9HC36	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	MRM3	Homo sapiens	Q9HC36	Validated Y2H	32296183
Intra	SCARF1	Q14162	MRM3	Homo sapiens	Q9HC36	Y2H Array	32296183
Intra	SCARF1	Q14162	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	SCARF1	Q14162	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	SCARF1	Q14162	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	SCARF1	Q14162	LCE1D	Homo sapiens	Q5T752	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	LCE1D	Homo sapiens	Q5T752	Validated Y2H	32296183
Intra	SCARF1	Q14162	LCE1D	Homo sapiens	Q5T752	Y2H Array	32296183
Intra	SCARF1	Q14162	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	SCARF1	Q14162	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	SCARF1	Q14162	KRTAP5-7	Homo sapiens	Q6L8G8	Validated Y2H	32296183
Intra	SCARF1	Q14162	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	SCARF1	Q14162	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SCARF1	Q14162	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	SCARF1	Q14162	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SCARF1	Q14162	LHFPL2	Homo sapiens	Q6ZUX7	Validated Y2H	32296183
Intra	SCARF1	Q14162	LHFPL2	Homo sapiens	Q6ZUX7	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	LHFPL2	Homo sapiens	Q6ZUX7	Y2H Array	32296183
Intra	SCARF1	Q14162	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	SCARF1	Q14162	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	SCARF1	Q14162	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	SCARF1	Q14162	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SCARF1	Q14162	TGM1	Homo sapiens	P22735	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	TGM1	Homo sapiens	P22735	Validated Y2H	32296183
Intra	SCARF1	Q14162	TGM1	Homo sapiens	P22735	Y2H Array	32296183
Intra	SCARF1	Q14162	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	SCARF1	Q14162	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	SCARF1	Q14162	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	SCARF1	Q14162	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	SCARF1	Q14162	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	SCARF1	Q14162	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	SCARF1	Q14162	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	SCARF1	Q14162	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	SCARF1	Q14162	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Acute Gonococcal Cervicitis

Gonococcal Cervicitis

Acute Gonorrhea Of Cervix

Acute Cervicitis

Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset

EMARDD	Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset, Mild Variant
Early-Onset Myopathy-Areflexia-Respiratory Distress-Dysphagia Syndrome	Early-Onset Myopathy, Areflexia, Respiratory Distress And Dysphagia
Myopathy, Early-Onset, Areflexia, Respiratory Distress, And Dysphagia

Ophthalmia Neonatorum

Gonococcal Conjunctivitis	Gonococcal Ophthalmia Neonatorum
Neonatal Conjunctivitis

Van Den Ende-Gupta Syndrome

VDEGS	Blepharophimosis, Arachnodactyly, And Congenital Contractures
Marden-Walker-Like Syndrome	Marden-Walker-Like Syndrome Without Psychomotor Retardation
Marden Walker Like Syndrome	Marden-Walker-Like Syndrome Without Psychmotor Retardation
Van Den Ende Gupta Syndrome	Marden Walker Like Syndrome Without Psychomotor Retardation
Blepharophimosis Arachnodactyly And Congenital Contractures

Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome	17p13.3 Duplication Syndrome
17p13.3 Microduplication Syndrome	Trisomy 17p13.3
Chromosome 17p13.3 Centromeric Duplication Syndrome	Dup(17)(P13.3)

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12490	SCARF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SCARF1	VGNC	VGNC:77027
Felis catus	SCARF1	VGNC	VGNC:99445
Bos taurus	SCARF1	VGNC	VGNC:34326
Mus musculus	SCARF1	MGD	MGI:2449455
Rattus norvegicus	SCARF1	RGD	RGD:1309330
Others	SCARF1	NCBI

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