2. Gene
  3. CLDN7 - claudin 7 Gene

CLDN7 - claudin 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1

Gene ID: 1366 | Gene type: protein coding

About CLDN7

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,259,903-7,263,213 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 165 orthologues and 22 paralogues. Biased expression in colon (RPKM 107.5), small intestine (RPKM 93.5) and 12 other tissues.

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast Cancer, ovarian Cancer, hepatocellular carcinomas, urinary tumors, prostate Cancer, lung Cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

CLDN7 Products(3)

mRNA Protein Name
NM_001185022.2 NP_001171951.1 claudin-7 isoform 1 precursor
NM_001185023.2 NP_001171952.1 claudin-7 isoform 2 precursor
NM_001307.6 NP_001298.3 claudin-7 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16054130 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12673207 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN7 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (5 - 182)

  • 0
  • 100
  • 211 a.a.
Protein Preferred Names Protein Names

claudin-7

clostridium perfringens enterotoxin receptor-like 2

CLDN7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CLDN7 O95471 UPK2 Homo sapiens O00526
Y2H Prey Pooling
32296183
Intra
CLDN7 O95471 EDDM3B Homo sapiens P56851
Validated Y2H
32296183
Intra
CLDN7 O95471 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
Intra
CLDN7 O95471 RTP2 Homo sapiens Q5QGT7
Validated Y2H
32296183
Intra
CLDN7 O95471 LSMEM2 Homo sapiens Q8N112
Validated Y2H
32296183
Intra
CLDN7 O95471 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
CLDN7 O95471 CYB561A3 Homo sapiens Q8NBI2
Validated Y2H
32296183
Intra
CLDN7 O95471 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
CLDN7 O95471 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
CLDN7 O95471 TMEM128 Homo sapiens Q5BJH2-2
Validated Y2H
32296183
Intra
CLDN7 O95471 ERMP1 Homo sapiens Q7Z2K6
Validated Y2H
32296183
Intra
CLDN7 O95471 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
CLDN7 O95471 ASGR1 Homo sapiens P07306
Validated Y2H
32296183
Intra
CLDN7 O95471 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra
CLDN7 O95471 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra
CLDN7 O95471 TSPAN33 Homo sapiens Q86UF1
Validated Y2H
32296183
Intra
CLDN7 O95471 SCARF1 Homo sapiens Q14162
Validated Y2H
32296183
Intra
CLDN7 O95471 MS4A13 Homo sapiens Q5J8X5
Validated Y2H
32296183
Intra
CLDN7 O95471 PGAP2 Homo sapiens Q9UHJ9-5
Validated Y2H
32296183
Intra
CLDN7 O95471 ANKRD46 Homo sapiens Q86W74-2
Validated Y2H
32296183
Intra
CLDN7 O95471 TMEM97 Homo sapiens Q5BJF2
Validated Y2H
32296183
Intra
CLDN7 O95471 FAXDC2 Homo sapiens Q96IV6
Validated Y2H
32296183
Intra
CLDN7 O95471 VSTM1 Homo sapiens Q6UX27-3
Validated Y2H
32296183
Intra
CLDN7 O95471 COL4A5 Homo sapiens P29400-2
Validated Y2H
32296183
Intra
CLDN7 O95471 NDUFB11 Homo sapiens Q9NX14
Validated Y2H
32296183
Intra
CLDN7 O95471 TMEM44 Homo sapiens Q2T9K0-2
Validated Y2H
32296183
Intra
CLDN7 O95471 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
CLDN7 O95471 CYBC1 Homo sapiens Q9BQA9
Y2H Prey Pooling
32296183
Intra
CLDN7 O95471 OLFM4 Homo sapiens Q6UX06
Validated Y2H
32296183
Intra
CLDN7 O95471 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
Intra
CLDN7 O95471 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
Intra
CLDN7 O95471 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
CLDN7 O95471 CD72 Homo sapiens P21854
Validated Y2H
32296183
Intra
CLDN7 O95471 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra
CLDN7 O95471 TNF Homo sapiens P01375
Validated Y2H
32296183
Intra
CLDN7 O95471 EMP3 Homo sapiens P54852
Validated Y2H
32296183
Intra
CLDN7 O95471 CXCL9 Homo sapiens Q07325
Validated Y2H
32296183
Intra
CLDN7 O95471 NKG7 Homo sapiens Q16617
Validated Y2H
32296183
Intra
CLDN7 O95471 MFSD5 Homo sapiens Q6N075
Validated Y2H
32296183
Intra
CLDN7 O95471 MAL Homo sapiens P21145
Validated Y2H
32296183
Intra
CLDN7 O95471 UNC93B1 Homo sapiens Q9H1C4
Validated Y2H
32296183
Intra
CLDN7 O95471 SCAMP4 Homo sapiens Q969E2
Validated Y2H
32296183
Intra
CLDN7 O95471 CLN6 Homo sapiens Q9NWW5
Validated Y2H
32296183
Intra
CLDN7 O95471 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra
CLDN7 O95471 CD53 Homo sapiens P19397
Validated Y2H
32296183
Intra
CLDN7 O95471 PLN Homo sapiens P26678
Validated Y2H
32296183
Intra
CLDN7 O95471 PLN Homo sapiens P26678
Y2H Array
32296183
Intra
CLDN7 O95471 BCL2L2 Homo sapiens Q92843
Validated Y2H
32296183
Intra
CLDN7 O95471 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra
CLDN7 O95471 SYNE4 Homo sapiens Q8N205
Validated Y2H
25416956
Intra
CLDN7 O95471 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
Intra
CLDN7 O95471 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
CLDN7 O95471 APOD Homo sapiens P05090
Validated Y2H
32296183
Intra
CLDN7 O95471 IGFBP5 Homo sapiens P24593
Validated Y2H
32296183
Intra
CLDN7 O95471 VAMP3 Homo sapiens Q15836
Validated Y2H
32296183
Intra
CLDN7 O95471 TMEM11 Homo sapiens P17152
Validated Y2H
32296183
Intra
CLDN7 O95471 MALL Homo sapiens Q13021
Validated Y2H
32296183
Intra
CLDN7 O95471 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
Intra
CLDN7 O95471 NIPAL4 Homo sapiens Q0D2K0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ductal Carcinoma In Situ

Noninfiltrating Intraductal Carcinoma
Oncocytoma

Oxyphilic Adenoma

Follicular Adenoma, Oxyphilic Cell

Adenoma, Oxyphilic

Hurthle Cell Tumor

Oncocytic Neoplasm
Diarrhea 5, With Tufting Enteropathy, Congenital

Congenital Diarrhea 5 With Tufting Enteropathy

Congenital Tufting Enteropathy

DIAR5

Cte

Intestinal Epithelial Cell Dysplasia

Tufting Enteropathy

Ied

Intestinal Epithelial Dysplasia

Enteropathy, Congenital Tufting

Congenital Diarrhoea 5 With Tufting Enteropathy

Congenital Familial Intractable Diarrhea With Epithelial Or Epithelium Abnormalities

Congenital Familial Intractable Diarrhoea With Epithelial Or Epithelium Abnormalities

Congenital Enteropathy

Congenital Familial Intractable Diarrhea With Enterocytes Assembly Abnormalities

Non-Syndromic Congenital Tufting Enteropathy

Diarrhea, Type 5, With Tufting Enteropathy, Congenital

Intestinal Intraepithelial Neoplasia
Prostate Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Prostate

Primary Prostate Urothelial Carcinoma
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Gastric Adenocarcinoma

Adenocarcinoma Of Stomach

Stomach Adenocarcinoma

Adenocarcinoma Gastric

Intestinal Type Adenocarcinoma Of Unspecified Site

Diffuse Type Adenocarcinoma Of Unspecified Site
Renal Oncocytoma

Oncocytoma, Renal

Oncocytoma Of Kidney

Renal Epithelial Oncocytic Tumor

Oncocytoma Kidney

Oncocytoma Renal

Kidney Oncocytoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Congenital Diarrhea
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Astigmatism
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02775 CLDN7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLDN7 MGD MGI:1859285
Bos taurus CLDN7 VGNC VGNC:55796
Felis catus CLDN7 VGNC VGNC:98884
Macaca mulatta CLDN7 VGNC VGNC:97752
Canis familiaris CLDN7 VGNC VGNC:53320
Rattus norvegicus CLDN7 RGD RGD:68432