GPR37L1 - G protein-coupled receptor 37 like 1 Gene

Homo sapiens

Also known as ETBRLP2; ETBR-LP-2; ET(B)R-LP-2

Gene ID: 9283 | Gene type: protein coding

About GPR37L1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,122,917-202,133,592 (from NCBI)

This gene has 7 transcripts (splice variants), 264 orthologues and 15 paralogues. Biased expression in brain (RPKM 18.1) and colon (RPKM 0.5).

Summary

Enables G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

GPR37L1 Products(1)

mRNA	Protein	Name
NM_004767.5	NP_004758.3	G-protein coupled receptor 37-like 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled peptide receptor activity	IDA IDA: Inferred from direct assay	23690594	GOA
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	27072655	GOA
enables peptide binding	IPI IPI: Inferred from physical interaction	23690594	GOA
NOT enables prosaposin receptor activity	IDA IDA: Inferred from direct assay	27072655	GOA
enables prosaposin receptor activity	IDA IDA: Inferred from direct assay	23690594	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20517885	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	23690594	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	23690594	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	28688853	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR37L1 Protein Structure

7tm_1

0
100
200
300
400
481 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 37-like 1

endothelin B receptor-like protein 2

GPR37L1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPR37L1	O60883	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	GPR37L1	O60883	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	GPR37L1	O60883	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	GPR37L1	O60883	CYB561A3	Homo sapiens	Q8NBI2	Validated Y2H	32296183
Intra	GPR37L1	O60883	SYNPR	Homo sapiens	Q8TBG9	Validated Y2H	32296183
Intra	GPR37L1	O60883	SYNPR	Homo sapiens	Q8TBG9	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	SYNPR	Homo sapiens	Q8TBG9	Y2H Array	32296183
Intra	GPR37L1	O60883	TMEM248	Homo sapiens	Q9NWD8	Validated Y2H	32296183
Intra	GPR37L1	O60883	TMEM248	Homo sapiens	Q9NWD8	Y2H Array	32296183
Intra	GPR37L1	O60883	TMEM248	Homo sapiens	Q9NWD8	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	GPR37L1	O60883	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	GPR37L1	O60883	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	GPR37L1	O60883	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	GPR37L1	O60883	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	GPR37L1	O60883	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	GPR37L1	O60883	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	GPR37L1	O60883	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	GPR37L1	O60883	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	GPR37L1	O60883	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	GPR37L1	O60883	CLDND2	Homo sapiens	Q8NHS1	Validated Y2H	32296183
Intra	GPR37L1	O60883	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
Intra	GPR37L1	O60883	SCARF1	Homo sapiens	Q14162	Validated Y2H	32296183
Intra	GPR37L1	O60883	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	GPR37L1	O60883	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	GPR37L1	O60883	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	GPR37L1	O60883	FXYD3	Homo sapiens	Q14802-3	Validated Y2H	32296183
Intra	GPR37L1	O60883	UPK1B	Homo sapiens	O75841	Validated Y2H	32296183
Intra	GPR37L1	O60883	AQP10	Homo sapiens	Q96PS8	Validated Y2H	32296183
Intra	GPR37L1	O60883	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	GPR37L1	O60883	CD46	Homo sapiens	P15529-3	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	CD46	Homo sapiens	P15529-3	Validated Y2H	32296183
Intra	GPR37L1	O60883	CD46	Homo sapiens	P15529-3	Y2H Array	32296183
Intra	GPR37L1	O60883	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	GPR37L1	O60883	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	GPR37L1	O60883	SCARB2	Homo sapiens	Q14108	Validated Y2H	32296183
Intra	GPR37L1	O60883	CLEC2A	Homo sapiens	Q6UVW9	Validated Y2H	32296183
Intra	GPR37L1	O60883	CLEC2A	Homo sapiens	Q6UVW9	Y2H Array	32296183
Intra	GPR37L1	O60883	CLEC2A	Homo sapiens	Q6UVW9	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	PDCD1LG2	Homo sapiens	Q9BQ51	Validated Y2H	32296183
Intra	GPR37L1	O60883	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Array	32296183
Intra	GPR37L1	O60883	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	GPR37L1	O60883	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	TMEM52B	Homo sapiens	Q4KMG9	Validated Y2H	32296183
Intra	GPR37L1	O60883	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	GPR37L1	O60883	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	GPR37L1	O60883	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	GPR37L1	O60883	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	GPR37L1	O60883	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	GPR37L1	O60883	RNF122	Homo sapiens	Q9H9V4	Validated Y2H	32296183
Intra	GPR37L1	O60883	RNF122	Homo sapiens	Q9H9V4	Y2H Array	32296183
Intra	GPR37L1	O60883	RNF122	Homo sapiens	Q9H9V4	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	TSPAN12	Homo sapiens	O95859	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	TSPAN12	Homo sapiens	O95859	Validated Y2H	32296183
Intra	GPR37L1	O60883	TSPAN12	Homo sapiens	O95859	Y2H Array	32296183
Intra	GPR37L1	O60883	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	GPR37L1	O60883	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	GPR37L1	O60883	PRCP	Homo sapiens	P42785	Protease Assay	20517885
Intra	GPR37L1	O60883	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	GPR37L1	O60883	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	GPR37L1	O60883	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	GPR37L1	O60883	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	GPR37L1	O60883	TMEM54	Homo sapiens	Q969K7	Validated Y2H	32296183
Intra	GPR37L1	O60883	UNC93B1	Homo sapiens	Q9H1C4	Validated Y2H	32296183
Intra	GPR37L1	O60883	PLN	Homo sapiens	P26678	Validated Y2H	32296183
Intra	GPR37L1	O60883	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	GPR37L1	O60883	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	GPR37L1	O60883	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	GPR37L1	O60883	IGFBP5	Homo sapiens	P24593	Validated Y2H	32296183
Intra	GPR37L1	O60883	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	THAP4	Homo sapiens	Q8WY91	Validated Y2H	32296183
Intra	GPR37L1	O60883	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183
Intra	GPR37L1	O60883	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	GPR37L1	O60883	CLDN7	Homo sapiens	O95471	Validated Y2H	32296183
Intra	GPR37L1	O60883	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	GPR37L1	O60883	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	GPR37L1	O60883	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	GPR37L1	O60883	TM4SF4	Homo sapiens	P48230	Validated Y2H	32296183
Intra	GPR37L1	O60883	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Epilepsy, Familial Temporal Lobe, 6

ETL6	Familial Temporal Lobe Epilepsy 6

Megalencephalic Leukoencephalopathy With Subcortical Cysts

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts	Mlc
Van Der Knaap Disease	Lvm
Leukoencephalopathy With Swelling And Cysts	Megalencephaly-Cystic Leukodystrophy
Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome	Infantile Leukoencephalopathy And Megalencephaly
Leukoencephalopathy With Swelling And A Discrepantly Mild Course	Vacuolating Leukoencephalopathy
Megalencephalic Leukodystrophy	Megalencephaly-Cystic Leukodystrophy Syndrome
Van Der Knaap Syndrome	Leukoencephalopathy, Megalencephalic, With Subcortical Cysts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1342A	Prosaptide Tx14(A) TFA	Activator	/	Unkown
HY-RS05710	GPR37L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPR37L1	VGNC	VGNC:62691
Canis familiaris	GPR37L1	VGNC	VGNC:41433
Macaca mulatta	GPR37L1	VGNC	VGNC:72943
Mus musculus	GPR37L1	MGD	MGI:1928503
Bos taurus	GPR37L1	VGNC	VGNC:29586
Rattus norvegicus	GPR37L1	RGD	RGD:628835

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