PLPP1 - phospholipid phosphatase 1 Gene

Homo sapiens

Also known as LPP1; PAP2; LLP1a; PAP-2a; PPAP2A

Gene ID: 8611 | Gene type: protein coding

About PLPP1

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,424,854-55,534,964 (from NCBI)

This gene has 6 transcripts (splice variants), 286 orthologues and 9 paralogues. Broad expression in prostate (RPKM 96.2), gall bladder (RPKM 74.3) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in Phospholipase D-mediated signal transduction. This Enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

PLPP1 Products(2)

mRNA	Protein	Name
NM_003711.4	NP_003702.2	phospholipid phosphatase 1 isoform 1
NM_176895.3	NP_795714.1	phospholipid phosphatase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ceramide-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	9705349	GOA
enables lipid phosphatase activity	IDA IDA: Inferred from direct assay	15461590	GOA
enables phosphatidate phosphatase activity	IDA IDA: Inferred from direct assay	9305923	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sphingosine-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	9705349	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	9305923	GOA
involved in phospholipid dephosphorylation	IDA IDA: Inferred from direct assay	9305923	GOA
involved in phospholipid metabolic process	IDA IDA: Inferred from direct assay	9305923	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	15461590	GOA
involved in sphingosine metabolic process	IDA IDA: Inferred from direct assay	9705349	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	14527693	GOA
located in membrane	IDA IDA: Inferred from direct assay	9305923	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	17005594	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9705349	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP1 Protein Structure

PAP2

0
100
200
284 a.a.

Protein Preferred Names

Protein Names

phospholipid phosphatase 1

lipid phosphate phosphohydrolase 1a

Related Diseases

Diseases

Alias

Myxosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10734	PLPP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PLPP1	VGNC	VGNC:44705
Mus musculus	PLPP1	MGD	MGI:108412
Bos taurus	PLPP1	VGNC	VGNC:33044
Macaca mulatta	PLPP1	VGNC	VGNC:76226
Rattus norvegicus	PLPP1	RGD	RGD:621832
Felis catus	PLPP1	VGNC	VGNC:68972

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