EIF4EBP3 - eukaryotic translation initiation factor 4E binding protein 3 Gene

Homo sapiens

Also known as 4EBP3; 4E-BP3

Gene ID: 8637 | Gene type: protein coding

About EIF4EBP3

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,547,662-140,549,576 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 14.1), kidney (RPKM 13.1) and 25 other tissues.

Summary

This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]

EIF4EBP3 Products(1)

mRNA	Protein	Name
NM_003732.3	NP_003723.1	eukaryotic translation initiation factor 4E-binding protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15153109	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4EBP3 Protein Structure

eIF_4EBP

0
100 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4E-binding protein 3

eIF4E-binding protein 3

EIF4EBP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF4EBP3	O60516	RPA2	Homo sapiens	P15927	Anti Bait CoIP	22684010
Intra	EIF4EBP3	O60516	EIF4E	Homo sapiens	P06730	Pull Down	9593750
Intra	EIF4EBP3	O60516	EIF4E	Homo sapiens	P06730	Anti Tag CoIP	33961781
Intra	EIF4EBP3	O60516	EIF4E	Homo sapiens	P06730	Y2H Prey Pooling	25416956
Intra	EIF4EBP3	O60516	EIF4E	Homo sapiens	P06730	Validated Y2H	25416956
Intra	EIF4EBP3	O60516	EIF4E	Homo sapiens	P06730	Far-WB	15153109
Intra	EIF4EBP3	O60516	EIF4E	Homo sapiens	P06730	Validated Y2H	32296183
Intra	EIF4EBP3	O60516	EIF4E	Homo sapiens	P06730	Y2H Array	25416956
Intra	EIF4EBP3	O60516	EIF4E	Homo sapiens	P06730	Pull Down	15153109
Cross	EIF4EBP3	O60516	Eif4e2	Mus musculus	Q80ZJ3	Far-WB	15153109

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Thymus Lymphoma

Thymic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04279	EIF4EBP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF4EBP3	RGD	RGD:2324556
Mus musculus	EIF4EBP3	MGD	MGI:1270847
Bos taurus	EIF4EBP3	VGNC	VGNC:106723

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