VAMP8 - vesicle associated membrane protein 8 Gene

Homo sapiens

Also known as EDB; VAMP-8

Gene ID: 8673 | Gene type: protein coding

About VAMP8

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,577,586-85,582,031 (from NCBI)

This gene has 3 transcripts (splice variants), 187 orthologues and 10 paralogues. Ubiquitous expression in colon (RPKM 79.3), placenta (RPKM 77.9) and 24 other tissues.

Summary

This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

VAMP8 Products(1)

mRNA	Protein	Name
NM_003761.5	NP_003752.2	vesicle-associated membrane protein 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chloride channel inhibitor activity	IDA IDA: Inferred from direct assay	18570918	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19557002	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	23217709	GOA
involved in autophagosome membrane docking	IDA IDA: Inferred from direct assay	25686604	GOA
NOT involved in eosinophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
involved in mucus secretion	IMP IMP: Inferred from mutant phenotype	22144578	GOA
involved in negative regulation of secretion by cell	IDA IDA: Inferred from direct assay	12130530	GOA
NOT involved in neutrophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
involved in positive regulation of histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	18253931	GOA
involved in regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	18570918	GOA
acts upstream of or within symbiont entry into host cell	IMP IMP: Inferred from mutant phenotype	24550300	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	12130530	GOA
located in azurophil granule membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18253931	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22589474	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	23217709	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	23217709	GOA
located in membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in mucin granule	IDA IDA: Inferred from direct assay	22144578	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18570918	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18253931	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	18570918	GOA
located in secretory granule membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in vesicle	IDA IDA: Inferred from direct assay	18570918	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAMP8 Protein Structure

Synaptobrevin

0
100 a.a.

Protein Preferred Names

Protein Names

vesicle-associated membrane protein 8

vesicle-associated membrane protein 8 (endobrevin)

VAMP8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VAMP8	Q9BV40	STX17	Homo sapiens	P56962	Anti Tag CoIP	23217709
Intra	VAMP8	Q9BV40	STX7	Homo sapiens	O15400	Anti Tag CoIP	19557002
Intra	VAMP8	Q9BV40	STX7	Homo sapiens	O15400	Anti Tag CoIP	33422265
Intra	VAMP8	Q9BV40	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	35271311
Intra	VAMP8	Q9BV40	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	23217709

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Familial Hemophagocytic Lymphohistiocytosis 5

Fhl5	Hlh5
Hplh5	Lymphohistiocytosis, Hemophagocytic, Familial, Type 5

Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4	FHL4
Hplh4	Hlh4
Lymphohistiocytosis, Hemophagocytic, Familial, Type 4

Hermansky-Pudlak Syndrome 2

HPS2	Hermansky Pudlak Syndrome 2
Platelet Defects And Oculocutaneous Albinism	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 2
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

Catecholaminergic Polymorphic Ventricular Tachycardia 1	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
CPVT1	Ventricular Tachycardia, Stress-Induced Polymorphic
Vtsip	Bidirectional Tachycardia
Stress-Induced Polymorphic Ventricular Tachycardia	Cvpt1
Double Tachycardia Induced By Catecholamines	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Paroxysmal Ventricular Fibrillation
Syncopal Paroxysmal Tachycardia	Syncopal Tachyarythmia
Ventricular Tachycardia Catecholaminergic Polymorphic 1	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1
Multifocal Pvcs	Multifocal Premature Ventricular Beats
Paroxysmal Familial Ventricular Fibrillation	Catecholaminergic Polymorphic Ventricular Tachycardia Type 1

Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency	VICIS
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum	Dionisi Vici Sabetta Gambarara Syndrome
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum	Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome
Dionisi-Vici-Sabetta-Gambarara Syndrome	Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15599	VAMP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VAMP8	VGNC	VGNC:36760
Rattus norvegicus	VAMP8	RGD	RGD:620421
Mus musculus	VAMP8	MGD	MGI:1336882
Felis catus	VAMP8	VGNC	VGNC:66914
Canis familiaris	VAMP8	VGNC	VGNC:48227
Macaca mulatta	VAMP8	VGNC	VGNC:78754

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