2. Gene
  3. TNFRSF14 - TNF receptor superfamily member 14 Gene

TNFRSF14 - TNF receptor superfamily member 14 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TR2; ATAR; HVEA; HVEM; CD270; LIGHTR

Gene ID: 8764 | Gene type: protein coding

About TNFRSF14

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:2,554,234-2,563,829 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 538 orthologues, 21 paralogues and is associated with 66 phenotypes. Ubiquitous expression in spleen (RPKM 22.9), duodenum (RPKM 21.7) and 23 other tissues.

Summary

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFRSF14 Products(2)

mRNA Protein Name
NM_001297605.2 NP_001284534.1 tumor necrosis factor receptor superfamily member 14 isoform 2 precursor
NM_003820.4 NP_003811.2 tumor necrosis factor receptor superfamily member 14 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cytokine binding IPI
IPI: Inferred from physical interaction
27152329 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9153189 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
11279055 GOA
Biological Process GO Annotation Evidence Reference Source
involved in T cell costimulation IDA
IDA: Inferred from direct assay
10754304 GOA
involved in negative regulation of adaptive immune memory response IDA
IDA: Inferred from direct assay
18193050 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
18193050 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF14 Protein Structure

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (78 - 119)

  • 0
  • 100
  • 200
  • 283 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 14

CD40-like protein

TNFRSF14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TNFRSF14 Q92956 TRAF2 Homo sapiens Q12933
Anti Bait CoIP
17353931
Intra
TNFRSF14 Q92956 TRAF2 Homo sapiens Q12933
Anti Bait CoIP
19332782
Intra
TNFRSF14 Q92956 TRAF2 Homo sapiens Q12933-2
Pull Down
9162022
Intra
TNFRSF14 Q92956 TRAF5 Homo sapiens O00463
Pull Down
9162022
Intra
TNFRSF14 Q92956 TNFSF14 Homo sapiens O43557
Yeast Display
26977880
Intra
TNFRSF14 Q92956 TNFSF14 Homo sapiens O43557
FACS
9462508
Intra
TNFRSF14 Q92956 FOXD4L6 Homo sapiens Q3SYB3
Y2H Pooling
32814053
Intra
TNFRSF14 Q92956 FOXD4L6 Homo sapiens Q3SYB3
Validated Y2H
32814053
Intra
TNFRSF14 Q92956 FOXD4L6 Homo sapiens Q3SYB3
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF14 Proteins

Cat. No. Product Name Accession Purity
HY-P7366 HVEM/TNFRSF14 Protein, Human (Sf9, Fc) Q92956 (L39-K184) ≥95%
HY-P70489 HVEM/TNFRSF14 Protein, Human (HEK293, His) Q92956 (L39-V202) ≥95%
HY-P700452 HVEM/TNFRSF14 Protein, Human (HEK293, hFc) Q92956 (L39-V202) ≥95%

Related Diseases

Diseases Alias
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065
Herpetic Whitlow

Herpetic Felon
Genital Herpes

Herpes Genitalis

Genital Herpes Simplex

Venereal Herpes

Virus-Genital Herpes
Acute Retinal Necrosis Syndrome

Acute Retinal Necrosis

Retinal Necrosis Syndrome, Acute
Nodal Marginal Zone Lymphoma

Mucosa-Associated Lymphoid Tissue Lymphoma

Monocytoid B-Cell Lymphoma
Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21

Iddm21

T1D21

Insulin-Dependent Diabetes Mellitus 21
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14806 TNFRSF14 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TNFRSF14 VGNC VGNC:80387
Macaca mulatta TNFRSF14 VGNC VGNC:78585
Canis familiaris TNFRSF14 VGNC VGNC:47658
Rattus norvegicus TNFRSF14 RGD RGD:1310115
Mus musculus TNFRSF14 MGD MGI:2675303
Others TNFRSF14 NCBI