SOCS2 - suppressor of cytokine signaling 2 Gene

Homo sapiens

Also known as CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2

Gene ID: 8835 | Gene type: protein coding

About SOCS2

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:93,569,969-93,626,236 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 7 paralogues. Broad expression in endometrium (RPKM 13.5), prostate (RPKM 10.5) and 22 other tissues.

Summary

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by Cytokine Receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

SOCS2 Products(6)

mRNA	Protein	Name
NM_001270467.2	NP_001257396.1	suppressor of cytokine signaling 2
NM_001270468.2	NP_001257397.1	suppressor of cytokine signaling 2
NM_001270469.2	NP_001257398.1	suppressor of cytokine signaling 2
NM_001270470.1	NP_001257399.1	suppressor of cytokine signaling 2
NM_001270471.2	NP_001257400.1	suppressor of cytokine signaling 2
NM_003877.5	NP_003868.1	suppressor of cytokine signaling 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables insulin-like growth factor receptor binding	IPI IPI: Inferred from physical interaction	9727029	GOA
enables phosphorylation-dependent protein binding	IDA IDA: Inferred from direct assay	11781573	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11781573	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	11781573	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hormone stimulus	IDA IDA: Inferred from direct assay	12552091	GOA
involved in growth hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	12552091	GOA
involved in negative regulation of growth hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	21980433	GOA
involved in negative regulation of signal transduction	IDA IDA: Inferred from direct assay	11781573	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	11781573	GOA
involved in response to estradiol	IDA IDA: Inferred from direct assay	12552091	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	21980433	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	9727029	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOCS2 Protein Structure

SH2

SOCS_box

0
100
198 a.a.

Protein Preferred Names

Protein Names

suppressor of cytokine signaling 2

CIS-2

SOCS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SOCS2	O14508	CUL5	Homo sapiens	Q93034	Lumier	29997244
Intra	SOCS2	O14508	CUL5	Homo sapiens	Q93034	Pull Down	30833792
Intra	SOCS2	O14508	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	33961781
Intra	SOCS2	O14508	CUL5	Homo sapiens	Q93034	BRET	29997244
Intra	SOCS2	O14508	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	28514442
Intra	SOCS2	O14508	CUL5	Homo sapiens	Q93034	Lumier	32814053
Intra	SOCS2	O14508	KIT	Homo sapiens	P10721	FPS	24728074
Intra	SOCS2	O14508	ELOC	Homo sapiens	Q15369	Anti Tag CoIP	19159283
Intra	SOCS2	O14508	YES1	Homo sapiens	P07947	Validated Y2H	32296183
Intra	SOCS2	O14508	EPOR	Homo sapiens	P19235	MAPPIT	11781573
Intra	SOCS2	O14508	STK16	Homo sapiens	O75716	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Placental Insufficiency

Uteroplacental Vascular Insufficiency

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Polycythemia Vera

PV	Polycythemia Rubra Vera
Prv	Osler-Vaquez Disease
Chronic Erythremia	Polycythaemia Rubra Vera
Primary Polycythemia	Vaquez Disease
Polycythemia Vera, Somatic	Osler-Vaquez Syndrome
Proliferative Polycythaemia	Polycythemia Ruba Vera
Acquired Primary Erythrocytosis	Heilmeyer-Schoner Disease
Vaquez Osler Disease	Primary Polycythaemia

Glycine N-Methyltransferase Deficiency

GNMT DEFICIENCY	Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency
Hypermethioninemia Due To Gnmt Deficiency	Hypermethioninemia
Hepatic Methionine Adenosyltransferase Deficiency

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156395	MN551	Inducer	98.05%	Unkown
HY-RS13553	SOCS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SOCS2	MGD	MGI:1201787
Felis catus	SOCS2	VGNC	VGNC:97640
Canis familiaris	SOCS2	VGNC	VGNC:46649
Rattus norvegicus	SOCS2	RGD	RGD:69273
Bos taurus	SOCS2	VGNC	VGNC:35120

Name
Email *

	Sorry, but the email address you supplied was invalid.