2. Gene
  3. CLIC3 - chloride intracellular channel 3 Gene

CLIC3 - chloride intracellular channel 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 9022 | Gene type: protein coding

About CLIC3

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,994,608-136,996,568 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues and 14 paralogues. Biased expression in esophagus (RPKM 23.8), thyroid (RPKM 21.4) and 5 other tissues.

Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]

CLIC3 Products(1)

mRNA Protein Name
NM_004669.3 NP_004660.2 chloride intracellular channel protein 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chloride channel activity IMP
IMP: Inferred from mutant phenotype
9880541 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9880541 GOA
enables protein-disulfide reductase (glutathione) activity IDA
IDA: Inferred from direct assay
28198360 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chloride transport IMP
IMP: Inferred from mutant phenotype
9880541 GOA
involved in positive regulation of sprouting angiogenesis IDA
IDA: Inferred from direct assay
28198360 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9880541 GOA
located in extracellular matrix IDA
IDA: Inferred from direct assay
28198360 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9880541 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLIC3 Protein Structure

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (21 - 87)

GST_C_2

GST_C_2: Glutathione S-transferase, C-terminal domain (127 - 207)

  • 0
  • 100
  • 200
  • 236 a.a.
Protein Preferred Names Protein Names

chloride intracellular channel protein 3

Recombinant CLIC3 Proteins

Cat. No. Product Name Accession Purity
HY-P7857 CLIC3 Protein, Human (His) O95833 (M1-R236) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02805 CLIC3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CLIC3 RGD RGD:1307249
Macaca mulatta CLIC3 VGNC VGNC:71255
Canis familiaris CLIC3 VGNC VGNC:39339
Bos taurus CLIC3 VGNC VGNC:27441
Mus musculus CLIC3 MGD MGI:1916704
Felis catus CLIC3 VGNC VGNC:60960
Others CLIC3 NCBI