BMF - Bcl2 modifying factor Gene

Homo sapiens

Gene ID: 90427 | Gene type: protein coding

About BMF

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,087,890-40,108,879 (from NCBI)

This gene has 10 transcripts (splice variants) and 175 orthologues. Ubiquitous expression in endometrium (RPKM 8.6), bone marrow (RPKM 8.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to Myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering Apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

BMF Products(20)

mRNA	Protein	Name
NM_001003940.2	NP_001003940.1	bcl-2-modifying factor isoform bmf-1
NM_001003942.2	NP_001003942.1	bcl-2-modifying factor isoform bmf-2
NM_001003943.3	NP_001003943.1	bcl-2-modifying factor isoform bmf-3
NM_001398495.1	NP_001385424.1	bcl-2-modifying factor isoform bmf-1
NM_001398496.1	NP_001385425.1	bcl-2-modifying factor isoform bmf-1
NM_001398497.1	NP_001385426.1	bcl-2-modifying factor isoform bmf-1
NM_001398498.1	NP_001385427.1	bcl-2-modifying factor isoform bmf-1
NM_001398499.1	NP_001385428.1	bcl-2-modifying factor isoform bmf-1
NM_001398500.1	NP_001385429.1	bcl-2-modifying factor isoform bmf-1
NM_001398501.1	NP_001385430.1	bcl-2-modifying factor isoform bmf-1
NM_001398502.1	NP_001385431.1	bcl-2-modifying factor isoform bmf-1
NM_001398503.1	NP_001385432.1	bcl-2-modifying factor isoform bmf-1
NM_001398504.1	NP_001385433.1	bcl-2-modifying factor isoform bmf-1
NM_001398505.1	NP_001385434.1	bcl-2-modifying factor isoform bmf-1
NM_001398506.1	NP_001385435.1	bcl-2-modifying factor isoform bmf-1
NM_001398507.1	NP_001385436.1	bcl-2-modifying factor isoform bmf-1
NM_001398508.1	NP_001385437.1	bcl-2-modifying factor isoform bmf-3
NM_001398509.1	NP_001385438.1	bcl-2-modifying factor isoform bmf-3
NM_001398510.1	NP_001385439.1	bcl-2-modifying factor isoform bmf-3
NM_033503.4	NP_277038.1	bcl-2-modifying factor isoform bmf-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11546872	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anoikis	IDA IDA: Inferred from direct assay	11546872	GOA
involved in cellular response to UV	IDA IDA: Inferred from direct assay	23629966	GOA
involved in negative regulation of autophagy	IDA IDA: Inferred from direct assay	23629966	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19671867	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMF Protein Structure

BMF

0
100
184 a.a.

Protein Preferred Names

Protein Names

bcl-2-modifying factor

BMF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BMF	Q96LC9	SEC14L4	Homo sapiens	Q9UDX3	Y2H Array	25416956
Intra	BMF	Q96LC9	SEC14L4	Homo sapiens	Q9UDX3	Y2H Prey Pooling	25416956
Intra	BMF	Q96LC9	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	BMF	Q96LC9	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	BMF	Q96LC9	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	BMF	Q96LC9	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	BMF	Q96LC9	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	BMF	Q96LC9	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	BMF	Q96LC9	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	BMF	Q96LC9	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	BMF	Q96LC9	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	BMF	Q96LC9	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	BMF	Q96LC9	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	BMF	Q96LC9	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	BMF	Q96LC9	BCL2L10	Homo sapiens	Q9HD36	Validated Y2H	32296183
Intra	BMF	Q96LC9	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	BMF	Q96LC9	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	BMF	Q96LC9	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	BMF	Q96LC9	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	BMF	Q96LC9	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	BMF	Q96LC9	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32296183
Intra	BMF	Q96LC9	DYNLL1	Homo sapiens	P63167	Y2H Prey Pooling	32296183
Intra	BMF	Q96LC9	DYNLL1	Homo sapiens	P63167	Y2H Array	32296183
Intra	BMF	Q96LC9	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	BMF	Q96LC9	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	BMF	Q96LC9	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	BMF	Q96LC9	BCL2L2	Homo sapiens	Q92843	Y2H Array	25416956
Intra	BMF	Q96LC9	BCL2L2	Homo sapiens	Q92843	Y2H Array	32296183
Intra	BMF	Q96LC9	BCL2L2	Homo sapiens	Q92843	Y2H Prey Pooling	32296183
Intra	BMF	Q96LC9	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	BMF	Q96LC9	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	BMF	Q96LC9	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	BMF	Q96LC9	DYNLL2	Homo sapiens	Q96FJ2	Y2H Array	25416956
Intra	BMF	Q96LC9	DYNLL2	Homo sapiens	Q96FJ2	Validated Y2H	25416956
Intra	BMF	Q96LC9	BCL2L1	Homo sapiens	Q07817	Y2H Prey Pooling	32296183
Intra	BMF	Q96LC9	BCL2L1	Homo sapiens	Q07817	Y2H Array	25416956
Intra	BMF	Q96LC9	BCL2L1	Homo sapiens	Q07817	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BMF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75473	BMF Protein, Human (His)	Q96LC9-1 (M1-R184)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50868	Bafetinib		99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150105	BMF-219	Inhibitor	98.72%	Unkown
HY-P1733	BMf-BH3		/	Unkown
HY-RS01531	BMF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BMF	VGNC	VGNC:70369
Felis catus	BMF	VGNC	VGNC:60128
Bos taurus	BMF	VGNC	VGNC:26513
Rattus norvegicus	BMF	RGD	RGD:628658
Canis familiaris	BMF	VGNC	VGNC:38474
Mus musculus	BMF	MGD	MGI:2176433
Others	BMF	NCBI

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