2. Gene
  3. BMF - Bcl2 modifying factor Gene

BMF - Bcl2 modifying factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 90427 | Gene type: protein coding

About BMF

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,087,890-40,108,879 (from NCBI)

This gene has 10 transcripts (splice variants) and 175 orthologues. Ubiquitous expression in endometrium (RPKM 8.6), bone marrow (RPKM 8.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to Myosin V motors by its association with dynein LIGHT chain 2, which may be important for sensing intracellular damage and triggering Apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

BMF Products(20)

mRNA Protein Name
NM_001003940.2 NP_001003940.1 bcl-2-modifying factor isoform bmf-1
NM_001003942.2 NP_001003942.1 bcl-2-modifying factor isoform bmf-2
NM_001003943.3 NP_001003943.1 bcl-2-modifying factor isoform bmf-3
NM_001398495.1 NP_001385424.1 bcl-2-modifying factor isoform bmf-1
NM_001398496.1 NP_001385425.1 bcl-2-modifying factor isoform bmf-1
NM_001398497.1 NP_001385426.1 bcl-2-modifying factor isoform bmf-1
NM_001398498.1 NP_001385427.1 bcl-2-modifying factor isoform bmf-1
NM_001398499.1 NP_001385428.1 bcl-2-modifying factor isoform bmf-1
NM_001398500.1 NP_001385429.1 bcl-2-modifying factor isoform bmf-1
NM_001398501.1 NP_001385430.1 bcl-2-modifying factor isoform bmf-1
NM_001398502.1 NP_001385431.1 bcl-2-modifying factor isoform bmf-1
NM_001398503.1 NP_001385432.1 bcl-2-modifying factor isoform bmf-1
NM_001398504.1 NP_001385433.1 bcl-2-modifying factor isoform bmf-1
NM_001398505.1 NP_001385434.1 bcl-2-modifying factor isoform bmf-1
NM_001398506.1 NP_001385435.1 bcl-2-modifying factor isoform bmf-1
NM_001398507.1 NP_001385436.1 bcl-2-modifying factor isoform bmf-1
NM_001398508.1 NP_001385437.1 bcl-2-modifying factor isoform bmf-3
NM_001398509.1 NP_001385438.1 bcl-2-modifying factor isoform bmf-3
NM_001398510.1 NP_001385439.1 bcl-2-modifying factor isoform bmf-3
NM_033503.4 NP_277038.1 bcl-2-modifying factor isoform bmf-1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11546872 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within anoikis IDA
IDA: Inferred from direct assay
11546872 GOA
involved in cellular response to UV IDA
IDA: Inferred from direct assay
23629966 GOA
involved in negative regulation of autophagy IDA
IDA: Inferred from direct assay
23629966 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19671867 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMF Protein Structure

BMF

BMF: Bcl-2-modifying factor, apoptosis (6 - 184)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

bcl-2-modifying factor

Recombinant BMF Proteins

Cat. No. Product Name Accession Purity
HY-P75473 BMF Protein, Human (His) Q96LC9-1 (M1-R184) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-50868 Bafetinib 99.77% Phase 2
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150105 BMF-219 Inhibitor 98.72% Unkown
HY-P1733 BMf-BH3 / Unkown
HY-RS01531 BMF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BMF VGNC VGNC:70369
Felis catus BMF VGNC VGNC:60128
Bos taurus BMF VGNC VGNC:26513
Rattus norvegicus BMF RGD RGD:628658
Canis familiaris BMF VGNC VGNC:38474
Mus musculus BMF MGD MGI:2176433
Others BMF NCBI