SH2D2A - SH2 domain containing 2A Gene

Homo sapiens

Also known as SCAP; TSAD; VRAP; F2771

Gene ID: 9047 | Gene type: protein coding

About SH2D2A

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,806,243-156,816,848 (from NCBI)

This gene has 6 transcripts (splice variants), 111 orthologues and 4 paralogues. Broad expression in appendix (RPKM 5.2), lymph node (RPKM 3.5) and 17 other tissues.

Summary

This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

SH2D2A Products(5)

mRNA	Protein	Name
NM_001161441.2	NP_001154913.1	SH2 domain-containing protein 2A isoform 1
NM_001161442.2	NP_001154914.1	SH2 domain-containing protein 2A isoform 3
NM_001161443.2	NP_001154915.1	SH2 domain-containing protein 2A isoform 4
NM_001161444.2	NP_001154916.1	SH2 domain-containing protein 2A isoform 2
NM_003975.4	NP_003966.2	SH2 domain-containing protein 2A isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10553045	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH2D2A Protein Structure

SH2

0
100
200
300
389 a.a.

Protein Preferred Names

Protein Names

SH2 domain-containing protein 2A

SH2 domain protein 2A

Related Diseases

Diseases

Alias

Brain Meningioma

Intracranial Meningioma

Polyradiculoneuropathy

Cerebral Meningioma

Meningioma Of Cerebrum

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Chronic Inflammatory Demyelinating Polyneuropathy	Cidp
Polyradiculoneuropathy Chronic Inflammatory Demyelinating	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Galloway-Mowat Syndrome

Galloway Mowat Syndrome	Galloway Syndrome
Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type	Microcephaly Nephrosis Syndrome
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Nephrosis Neuronal Dysmigration Syndrome
Microcephaly-Hiatus Hernia-Nephrotic Syndrome	Nephrosis-Neuronal Dysmigration Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12823	SH2D2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SH2D2A	VGNC	VGNC:46111
Rattus norvegicus	SH2D2A	RGD	RGD:1303076
Mus musculus	SH2D2A	MGD	MGI:1351596
Bos taurus	SH2D2A	VGNC	VGNC:34557
Felis catus	SH2D2A	VGNC	VGNC:65092
Macaca mulatta	SH2D2A	VGNC	VGNC:77198

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