2. Gene
  3. LASP1 - LIM and SH3 protein 1 Gene

LASP1 - LIM and SH3 protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MLN50; Lasp-1

Gene ID: 3927 | Gene type: protein coding

About LASP1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,870,058-38,921,770 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues, 4 paralogues and is associated with 52 phenotypes. Ubiquitous expression in small intestine (RPKM 79.0), duodenum (RPKM 59.7) and 25 other tissues.

Summary

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin Cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast Cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal Cancer. [provided by RefSeq, Oct 2012]

LASP1 Products(2)

mRNA Protein Name
NM_001271608.2 NP_001258537.1 LIM and SH3 domain protein 1 isoform b
NM_006148.4 NP_006139.1 LIM and SH3 domain protein 1 isoform a
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25468996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LASP1 Protein Structure

LIM

LIM: LIM domain (5 - 59)

Nebulin

Nebulin: Nebulin repeat (67 - 95)

Nebulin

Nebulin: Nebulin repeat (103 - 130)

SH3_9

SH3_9: Variant SH3 domain (209 - 259)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

LIM and SH3 domain protein 1

metastatic lymph node gene 50 protein

LASP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LASP1 Q14847 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
Intra
LASP1 Q14847 TJP2 Homo sapiens Q9UDY2
Far-WB
22665060
Intra
LASP1 Q14847 TJP2 Homo sapiens Q9UDY2
PLA
22665060
Intra
LASP1 Q14847 TJP2 Homo sapiens Q9UDY2
Pull Down
22665060
Intra
LASP1 Q14847 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
LASP1 Q14847 PSMA3 Homo sapiens P25788
Validated Y2H
25416956
Intra
LASP1 Q14847 TRIP13 Homo sapiens Q15645
Validated Y2H
25416956
Intra
LASP1 Q14847 TRIP13 Homo sapiens Q15645
Y2H Pooling
16189514
Intra
LASP1 Q14847 TRIP13 Homo sapiens Q15645
Y2H
21516116
Intra
LASP1 Q14847 RHOXF2 Homo sapiens Q9BQY4
Y2H Array
25416956
Intra
LASP1 Q14847 ZBTB9 Homo sapiens Q96C00
Y2H Array
31515488
Intra
LASP1 Q14847 ZBTB9 Homo sapiens Q96C00
Validated Y2H
25416956
Intra
LASP1 Q14847 ZBTB9 Homo sapiens Q96C00
Y2H Array
25416956
Intra
LASP1 Q14847 ZBTB9 Homo sapiens Q96C00
Y2H Prey Pooling
25416956
Intra
LASP1 Q14847 SH2D2A Homo sapiens Q9NP31
Lumier
25814554
Intra
LASP1 Q14847 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
LASP1 Q14847 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
Intra
LASP1 Q14847 ZC2HC1A Homo sapiens Q96GY0
Y2H Array
25416956
Intra
LASP1 Q14847 ZC2HC1A Homo sapiens Q96GY0
Validated Y2H
25416956
Intra
LASP1 Q14847 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
LASP1 Q14847 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
LASP1 Q14847 MDFI Homo sapiens Q99750
Y2H Array
19060904
Intra
LASP1 Q14847 MDFI Homo sapiens Q99750
Y2H Pooling
19060904
Intra
LASP1 Q14847 SEPTIN3 Homo sapiens Q9UH03
Y2H Prey Pooling
25416956
Intra
LASP1 Q14847 ARHGEF15 Homo sapiens O94989
Validated Y2H
25416956
Intra
LASP1 Q14847 ARHGEF15 Homo sapiens O94989
Y2H Array
25416956
Intra
LASP1 Q14847 ARHGEF15 Homo sapiens O94989
Y2H Prey Pooling
25416956
Intra
LASP1 Q14847 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
LASP1 Q14847 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
Intra
LASP1 Q14847 SPRY2 Homo sapiens O43597
Y2H Prey Pooling
25416956
Intra
LASP1 Q14847 SPRY2 Homo sapiens O43597
Validated Y2H
25416956
Intra
LASP1 Q14847 SPRY2 Homo sapiens O43597
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07535 LASP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LASP1 MGD MGI:109656
Rattus norvegicus LASP1 RGD RGD:68408
Macaca mulatta LASP1 VGNC VGNC:74237
Bos taurus LASP1 VGNC VGNC:30798
Felis catus LASP1 VGNC VGNC:99182
Canis familiaris LASP1 VGNC VGNC:42595
Others LASP1 NCBI