MAP3K6 - mitogen-activated protein kinase kinase kinase 6 Gene

Homo sapiens

Also known as ASK2; MEKK6; MAPKKK6

Gene ID: 9064 | Gene type: protein coding

About MAP3K6

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,355,184-27,366,961 (from NCBI)

This gene has 8 transcripts (splice variants), 193 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 18.7), fat (RPKM 11.6) and 21 other tissues.

Summary

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MAP3K6 Products(2)

mRNA	Protein	Name
NM_001297609.2	NP_001284538.1	mitogen-activated protein kinase kinase kinase 6 isoform 2
NM_004672.5	NP_004663.3	mitogen-activated protein kinase kinase kinase 6 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9875215	GOA
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	9875215	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	9875215	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19935702	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9875215	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K6 Protein Structure

DUF4071

Pkinase

0
200
400
600
800
1000
1200
1288 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 6

apoptosis signal-regulating kinase 2

MAP3K6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP3K6	O95382	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	MAP3K6	O95382	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
Intra	MAP3K6	O95382	SFN	Homo sapiens	P31947	Pull Down	32707033

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Diffuse Gastric And Lobular Breast Cancer Syndrome

Hereditary Diffuse Gastric Cancer	HDGC
LBC	Familial Diffuse Gastric Cancer
Fdgc	Hereditary Diffuse Gastric Adenocarcinoma
Breast Cancer, Lobular	Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate
DGLBC	Gastric Cancer, Hereditary Diffuse
Gastric Cancer, Familial Diffuse Breast Cancer, Lobular	Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate
E-Cadherin-Associated Hereditary Gastric Cancer	Familial Diffuse Cancer Of Stomach
Hereditary Diffuse Cancer Of Stomach	Gastric Cancer Familial Diffuse
Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate	Cancer, Gastric, Hereditary Diffuse

Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma	Hereditary Diffuse Gastric Cancer
Signet Cell Adenocarcinoma	Signet Ring Cell Carcinoma
Signet Ring Cell Gastric Carcinoma	Signet Ring Gastric Carcinoma
Fdgc	Familial Diffuse Cancer Of Stomach
Familial Diffuse Gastric Cancer	Gastric Cancer, Familial Diffuse
Gastric Cancer, Hereditary Diffuse	Hdgc
Hereditary Diffuse Cancer Of Stomach	Diffuse Gastric Cancer Syndrome
Cancer, Gastric, Diffuse	Carcinoma, Signet Ring Cell
Gastric Signet Ring Carcinoma

Enchondromatosis, Multiple, Ollier Type

Ollier Disease	Enchondromatosis
Dyschondroplasia	Osteochondromatosis
Multiple Cartilaginous Enchondroses	Multiple Enchondromatosis
Enchondromatosis With Haemangiomata	Enchondromatosis, Multiple
Kast'S Syndrome	Ollier'S Syndrome
Enchondromatosis Multiple	ENCHOM
Maffucci Disease	Olliers Disease
Hereditary Multiple Exostoses	Chondromatosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08061	MAP3K6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAP3K6	VGNC	VGNC:31199
Rattus norvegicus	MAP3K6	RGD	RGD:1304625
Macaca mulatta	MAP3K6	VGNC	VGNC:74496
Felis catus	MAP3K6	VGNC	VGNC:68160
Mus musculus	MAP3K6	MGD	MGI:1855691
Canis familiaris	MAP3K6	VGNC	VGNC:42976
Others	MAP3K6	NCBI

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