2. Gene
  3. CLDN8 - claudin 8 Gene

CLDN8 - claudin 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HEL-S-79

Gene ID: 9073 | Gene type: protein coding

About CLDN8

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:30,214,006-30,216,097 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues and 22 paralogues.

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]

CLDN8 Products(1)

mRNA Protein Name
NM_199328.3 NP_955360.1 claudin-8
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN8 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (6 - 182)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

claudin-8

epididymis secretory protein Li 79

CLDN8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CLDN8 P56748 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
CLDN8 P56748 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
CLDN8 P56748 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
CLDN8 P56748 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
CLDN8 P56748 CLEC17A Homo sapiens Q6ZS10
Validated Y2H
32296183
Intra
CLDN8 P56748 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
Intra
CLDN8 P56748 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 PKMYT1 Homo sapiens Q99640-2
Validated Y2H
32296183
Intra
CLDN8 P56748 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
CLDN8 P56748 ADAM32 Homo sapiens Q8TC27
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 ADAM32 Homo sapiens Q8TC27
Validated Y2H
32296183
Intra
CLDN8 P56748 ADAM32 Homo sapiens Q8TC27
Y2H Array
32296183
Intra
CLDN8 P56748 SYNE4 Homo sapiens Q8N205
Y2H Array
25416956
Intra
CLDN8 P56748 SMIM3 Homo sapiens Q9BZL3
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
Intra
CLDN8 P56748 SMIM3 Homo sapiens Q9BZL3
Y2H Array
32296183
Intra
CLDN8 P56748 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
CLDN8 P56748 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

CLDN8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81424 Claudin 8 Antibody (YA1169) IHC-P Human

Related Diseases

Diseases Alias
Renal Oncocytoma

Oncocytoma, Renal

Oncocytoma Of Kidney

Renal Epithelial Oncocytic Tumor

Oncocytoma Kidney

Oncocytoma Renal

Kidney Oncocytoma
Oncocytoma

Oxyphilic Adenoma

Follicular Adenoma, Oxyphilic Cell

Adenoma, Oxyphilic

Hurthle Cell Tumor

Oncocytic Neoplasm
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Pseudohypoaldosteronism
Acute Salpingitis
Deafness, Autosomal Recessive 29

DFNB29

Autosomal Recessive Nonsyndromic Deafness 29

Autosomal Recessive Deafness 29

Deafness, Autosomal Recessive, 29

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29

Deafness, Autosomal Recessive, Type 29
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02776 CLDN8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLDN8 MGD MGI:1859286
Felis catus CLDN8 VGNC VGNC:102673
Macaca mulatta CLDN8 VGNC VGNC:81289
Bos taurus CLDN8 VGNC VGNC:27419
Rattus norvegicus CLDN8 RGD RGD:1308575
Canis familiaris CLDN8 VGNC VGNC:53023