2. Gene
  3. PKMYT1 - protein kinase, membrane associated tyrosine/threonine 1 Gene

PKMYT1 - protein kinase, membrane associated tyrosine/threonine 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MYT1; PPP1R126

Gene ID: 9088 | Gene type: protein coding

About PKMYT1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,972,808-2,980,446 (from NCBI)

This gene has 20 transcripts (splice variants), 181 orthologues and 8 paralogues. Broad expression in testis (RPKM 14.8), bone marrow (RPKM 10.4) and 16 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

PKMYT1 Products(4)

mRNA Protein Name
NM_001258450.2 NP_001245379.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3
NM_001258451.2 NP_001245380.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 4
NM_004203.5 NP_004194.3 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1
NM_182687.3 NP_872629.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables kinase activity IDA
IDA: Inferred from direct assay
9268380 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10373560 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9268380 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
9268380 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKMYT1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (111 - 357)

  • 0
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  • 400
  • 499 a.a.
Protein Preferred Names Protein Names

membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

myt1 kinase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145817A lunresertib Inhibitor 99.90% Phase 2
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147312 GSK-1520489A Inhibitor 98.33% Unkown
HY-145666 Myt1-IN-3 Inhibitor 99.14% Unkown
HY-163490 PKMYT1-IN-1 Inhibitor / Unkown
HY-162849 PKMYT1-IN-3 Inhibitor / Unkown
HY-163491 PKMYT1-IN-2 Inhibitor / Unkown
HY-RS10605 PKMYT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-162986 PKMYT1-IN-4 Inhibitor / Unkown
HY-162987 PKMYT1-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PKMYT1 VGNC VGNC:64194
Mus musculus PKMYT1 MGD MGI:2137630
Macaca mulatta PKMYT1 VGNC VGNC:75885
Canis familiaris PKMYT1 VGNC VGNC:44610
Bos taurus PKMYT1 VGNC VGNC:32944
Rattus norvegicus PKMYT1 RGD RGD:1305434
Others PKMYT1 NCBI