PKMYT1 - protein kinase, membrane associated tyrosine/threonine 1 Gene

Homo sapiens

Also known as MYT1; PPP1R126

Gene ID: 9088 | Gene type: protein coding

About PKMYT1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,972,808-2,980,446 (from NCBI)

This gene has 20 transcripts (splice variants), 181 orthologues and 8 paralogues. Broad expression in testis (RPKM 14.8), bone marrow (RPKM 10.4) and 16 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

PKMYT1 Products(4)

mRNA	Protein	Name
NM_001258450.2	NP_001245379.1	membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3
NM_001258451.2	NP_001245380.1	membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 4
NM_004203.5	NP_004194.3	membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1
NM_182687.3	NP_872629.1	membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase activity	IDA IDA: Inferred from direct assay	9268380	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10373560	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9268380	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	9268380	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKMYT1 Protein Structure

Pkinase

0
100
200
300
400
499 a.a.

Protein Preferred Names

Protein Names

membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

myt1 kinase

PKMYT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PKMYT1	Q99640	CDK1	Homo sapiens	P06493	Pull Down	32707033
Intra	PKMYT1	Q99640	CDK1	Homo sapiens	P06493	Anti Tag CoIP	35271311
Intra	PKMYT1	Q99640	CCNB1	Homo sapiens	P14635	Anti Tag CoIP	10373560
Intra	PKMYT1	Q99640	CCNB1	Homo sapiens	P14635	Pull Down	32707033
Intra	PKMYT1	Q99640	CCNB1	Homo sapiens	P14635	Anti Tag CoIP	35271311
Intra	PKMYT1	Q99640	CCNB1	Homo sapiens	P14635	PLA	23397142

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145817A	lunresertib	Inhibitor	99.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147312	GSK-1520489A	Inhibitor	98.33%	Unkown
HY-145666	Myt1-IN-3	Inhibitor	99.14%	Unkown
HY-163490	PKMYT1-IN-1	Inhibitor	/	Unkown
HY-162849	PKMYT1-IN-3	Inhibitor	/	Unkown
HY-163491	PKMYT1-IN-2	Inhibitor	/	Unkown
HY-RS10605	PKMYT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-162986	PKMYT1-IN-4	Inhibitor	/	Unkown
HY-162987	PKMYT1-IN-6	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PKMYT1	VGNC	VGNC:64194
Mus musculus	PKMYT1	MGD	MGI:2137630
Macaca mulatta	PKMYT1	VGNC	VGNC:75885
Canis familiaris	PKMYT1	VGNC	VGNC:44610
Bos taurus	PKMYT1	VGNC	VGNC:32944
Rattus norvegicus	PKMYT1	RGD	RGD:1305434
Others	PKMYT1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.