SESTD1 - SEC14 and spectrin domain containing 1 Gene

Homo sapiens

Also known as SOLO

Gene ID: 91404 | Gene type: protein coding

About SESTD1

This gene has 9 transcripts (splice variants), 211 orthologues and 22 paralogues. Ubiquitous expression in fat (RPKM 11.0), lung (RPKM 7.2) and 24 other tissues.

Summary

Enables phosphatidylinositol-3,4-bisphosphate binding activity and phospholipid binding activity. Involved in negative regulation of calcium ion transmembrane transport via high voltage-gated Calcium Channel. Located in intermediate filament Cytoskeleton. Colocalizes with Calcium Channel complex. [provided by Alliance of Genome Resources, Apr 2022]

SESTD1 Products(1)

mRNA	Protein	Name
NM_178123.5	NP_835224.3	SEC14 domain and spectrin repeat-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables 1-phosphatidylinositol binding	IDA IDA: Inferred from direct assay	20164195	GOA
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	20164195	GOA
NOT enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	20164195	GOA
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	20164195	GOA
enables phosphatidylinositol-3,5-bisphosphate binding	IDA IDA: Inferred from direct assay	20164195	GOA
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	20164195	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	20164195	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	20164195	GOA
enables phosphatidylinositol-5-phosphate binding	IDA IDA: Inferred from direct assay	20164195	GOA
NOT enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	20164195	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20164195	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IMP IMP: Inferred from mutant phenotype	20164195	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcium channel complex	IPI IPI: Inferred from physical interaction	20164195	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SESTD1 Protein Structure

CRAL_TRIO_2

0
200
400
600
696 a.a.

Protein Preferred Names

Protein Names

SEC14 domain and spectrin repeat-containing protein 1

SEC14 and spectrin domains 1

Related Diseases

Diseases

Alias

Post-Vaccinal Encephalitis

Encephalitis Following Immunization Procedures	Postvaccinal Encephalomyelitis
Encephalomyelitis, Acute Disseminated

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12737	SESTD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SESTD1	VGNC	VGNC:46050
Bos taurus	SESTD1	VGNC	VGNC:56146
Mus musculus	SESTD1	MGD	MGI:1916262
Rattus norvegicus	SESTD1	RGD	RGD:1562244
Macaca mulatta	SESTD1	VGNC	VGNC:77267
Felis catus	SESTD1	VGNC	VGNC:65037

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