2. Gene
  3. STMN2 - stathmin 2 Gene

STMN2 - stathmin 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SCG10; SCGN10

Gene ID: 11075 | Gene type: protein coding

About STMN2

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:79,611,117-79,666,158 (from NCBI)

This gene has 3 transcripts (splice variants), 284 orthologues and 4 paralogues. Biased expression in brain (RPKM 155.5) and adrenal (RPKM 33.4).

Summary

This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

STMN2 Products(2)

mRNA Protein Name
NM_001199214.2 NP_001186143.1 stathmin-2 isoform 1
NM_007029.4 NP_008960.2 stathmin-2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
21215777 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to nerve growth factor stimulus IDA
IDA: Inferred from direct assay
21215777 GOA
involved in negative regulation of microtubule depolymerization IDA
IDA: Inferred from direct assay
18452648 GOA
involved in negative regulation of microtubule polymerization IDA
IDA: Inferred from direct assay
18452648 GOA
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
18452648 GOA
involved in positive regulation of microtubule depolymerization IDA
IDA: Inferred from direct assay
18452648 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
18452648 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21215777 GOA
located in growth cone IDA
IDA: Inferred from direct assay
21215777 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
21215777 GOA
located in neuron projection IDA
IDA: Inferred from direct assay
21215777 GOA
located in neuronal cell body IDA
IDA: Inferred from direct assay
21215777 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18452648 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STMN2 Protein Structure

Stathmin

Stathmin: Stathmin family (38 - 176)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

stathmin-2

neuron-specific growth-associated protein

STMN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STMN2 Q93045 TEX11 Homo sapiens Q8IYF3-3
Y2H Prey Pooling
32296183
Intra
STMN2 Q93045 TEX11 Homo sapiens Q8IYF3-3
Y2H Array
32296183
Intra
STMN2 Q93045 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
STMN2 Q93045 MBD3 Homo sapiens O95983-2
Y2H Array
32296183
Intra
STMN2 Q93045 TXLNA Homo sapiens P40222
Y2H Array
25416956
Intra
STMN2 Q93045 TXLNA Homo sapiens P40222
Y2H Array
31515488
Intra
STMN2 Q93045 TXLNA Homo sapiens P40222
Y2H Prey Pooling
25416956
Intra
STMN2 Q93045 TXLNA Homo sapiens P40222
Validated Y2H
25416956
Intra
STMN2 Q93045 CIB1 Homo sapiens Q99828
PLA
21215777
Intra
STMN2 Q93045 CIB1 Homo sapiens Q99828
Anti Tag CoIP
21215777
Intra
STMN2 Q93045 SESTD1 Homo sapiens Q86VW0
Y2H Prey Pooling
32296183
Intra
STMN2 Q93045 SESTD1 Homo sapiens Q86VW0
Y2H Array
32296183
Intra
STMN2 Q93045 TFCP2 Homo sapiens Q12800
Validated Y2H
25416956
Intra
STMN2 Q93045 TFCP2 Homo sapiens Q12800
Y2H Prey Pooling
25416956
Intra
STMN2 Q93045 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
STMN2 Q93045 TEX11 Homo sapiens Q8IYF3
Pull Down
16189514
Intra
STMN2 Q93045 TEX11 Homo sapiens Q8IYF3
Validated Y2H
25416956
Intra
STMN2 Q93045 TEX11 Homo sapiens Q8IYF3
Y2H Array
25416956
Intra
STMN2 Q93045 TEX11 Homo sapiens Q8IYF3
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trichorhinophalangeal Syndrome, Type Ii

Langer-Giedion Syndrome

Lgs

Trichorhinophalangeal Syndrome Type Ii

Trichorhinophalangeal Syndrome Type 2

TRPS2

Monosomy 8q24.1

Chromosome 8q24.1 Deletion Syndrome

Deletion 8q24.1

Giedion-Langer Syndrome

Trichorhinophalangeal Dysplasia Type Ii

Langer Giedion Syndrome

Trps 2

Tricho-Rhino-Phalangeal Syndrome Type Ii

Trichorhinophalangeal Syndrome With Exostosis

Trps Ii

Tricho-Rhino-Phalangeal Syndrome 2

8q24.1 Microdeletion Syndrome

8q24.1 Deletion Syndrome
Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob Disease

CJD

Bovine Spongiform Encephalopathy

Vcjd

Inherited Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Disease, Familial

Creutzfeldt Jakob Disease

Creutzfeldt-Jacob Disease

Creutzfeldt Jacob Disease

Sporadic Creutzfeldt-Jakob Disease

Encephalopathy, Bovine Spongiform

Creutzfeldt-Jakob Disease, Variant, Resistance To

Creutzfeldt-Jakob Disease, Variant

Creutzfeldt Jacob Syndrome

Jakob-Creutzfeldt Disease

Subacute Spongiform Encephalopathy

Transmissible Virus Dementia

New Variant Of Cjd

Nv-Cjd

Variant Cjd

Variant Creutzfeldt-Jacob Disease

Sporadic Cjd

Inherited Cjd

Acquired Creutzfeldt-Jakob Disease

Variant Mcj

Encephalopathy Bovine Spongiform

Familial Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Syndrome

New Variant Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Disease, Sporadic

Acquired Cjd

Scjd - [Sporadic Creutzfeldt-Jakob Disease]

Idiopathic Creutzfeldt-Jakob Disease

Creutzfeld-Jakob Disease Nos

Vcjd - [Variant Creutzfeldt-Jakob Disease]
Kuru

Kuru, Susceptibility To

Kuru Encephalopathy

Kuru Encephalitis

Kuru Disease
Budd-Chiari Syndrome

Hepatic Vein Thrombosis

Chiari Syndrome

BDCHS

Membranous Obstruction Of The Inferior Vena Cava

Budd-Chiari Syndrome, Somatic

Movc

Budd-Chiari Syndrome, Susceptibility To, Somatic

Budd-Chiari Syndrome, Susceptibility To

Membranous Obstruction Of Inferior Vena Cava

Hepatic Vein Block

Obstruction Of Hepatic Veins

Hepatic Vein Obstruction

Hepatic Venous Block
Chromosome 8q21.11 Deletion Syndrome

8q21.11 Microdeletion Syndrome

Del(8)(Q21.11)

Deletion 8q21.11

Monosomy 8q21.11
Goldberg-Shprintzen Syndrome

Goldberg-Shprintzen Megacolon Syndrome

GOSHS

Megacolon-Microcephaly Syndrome
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia
Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13944 STMN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STMN2 MGD MGI:98241
Rattus norvegicus STMN2 RGD RGD:68947
Canis familiaris STMN2 VGNC VGNC:46926
Felis catus STMN2 VGNC VGNC:81677
Bos taurus STMN2 VGNC VGNC:35404
Macaca mulatta STMN2 VGNC VGNC:78038