2. Gene
  3. GPS2 - G protein pathway suppressor 2 Gene

GPS2 - G protein pathway suppressor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AMF-1

Gene ID: 2874 | Gene type: protein coding

About GPS2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,312,661-7,315,360 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele and 222 orthologues. Ubiquitous expression in testis (RPKM 54.8), spleen (RPKM 24.3) and 25 other tissues.

Summary

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

GPS2 Products(1)

mRNA Protein Name
NM_004489.5 NP_004480.1 G protein pathway suppressor 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
15159402 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11931768 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
19481530 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
11931768 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of JNK cascade IDA
IDA: Inferred from direct assay
11931768 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11931768 GOA
involved in positive regulation of cholesterol efflux IDA
IDA: Inferred from direct assay
19481530 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19481530 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
29499132 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
29499132 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19858209 GOA
part of transcription repressor complex IDA
IDA: Inferred from direct assay
12628926 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G protein pathway suppressor 2

GPS-2

GPS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GPS2 Q13227 NDOR1 Homo sapiens Q9UHB4
Validated Y2H
32296183
Intra
GPS2 Q13227 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
GPS2 Q13227 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
Intra
GPS2 Q13227 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
GPS2 Q13227 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra
GPS2 Q13227 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
GPS2 Q13227 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra
GPS2 Q13227 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
GPS2 Q13227 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
GPS2 Q13227 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
Intra
GPS2 Q13227 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
Intra
GPS2 Q13227 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra
GPS2 Q13227 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra
GPS2 Q13227 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
GPS2 Q13227 ACTMAP Homo sapiens Q5BKX5-3
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 ACTMAP Homo sapiens Q5BKX5-3
Validated Y2H
32296183
Intra
GPS2 Q13227 ACTMAP Homo sapiens Q5BKX5-3
Y2H Array
32296183
Intra
GPS2 Q13227 KRTAP6-1 Homo sapiens Q3LI64
Validated Y2H
32296183
Intra
GPS2 Q13227 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra
GPS2 Q13227 FAM168B Homo sapiens A1KXE4-2
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 FAM168B Homo sapiens A1KXE4-2
Y2H Array
32296183
Intra
GPS2 Q13227 SMUG1 Homo sapiens Q53HV7-2
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 SMUG1 Homo sapiens Q53HV7-2
Validated Y2H
32296183
Intra
GPS2 Q13227 SMUG1 Homo sapiens Q53HV7-2
Y2H Array
32296183
Intra
GPS2 Q13227 UBTD2 Homo sapiens Q8WUN7
Validated Y2H
32296183
Intra
GPS2 Q13227 TBL1X Homo sapiens O60907-2
Pull Down
21240272
Intra
GPS2 Q13227 TBL1X Homo sapiens O60907-2
Anti Tag CoIP
28514442
Intra
GPS2 Q13227 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
GPS2 Q13227 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
GPS2 Q13227 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
17895379
Intra
GPS2 Q13227 HDAC1 Homo sapiens Q13547
Pull Down
17895379
Intra
GPS2 Q13227 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
GPS2 Q13227 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
GPS2 Q13227 HNRNPH1 Homo sapiens P31943
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 HNRNPH1 Homo sapiens P31943
Y2H Array
32296183
Intra
GPS2 Q13227 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
GPS2 Q13227 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
GPS2 Q13227 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
GPS2 Q13227 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
GPS2 Q13227 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra
GPS2 Q13227 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra
GPS2 Q13227 ATF4 Homo sapiens P18848
Y2H Array
29892012
Intra
GPS2 Q13227 ATF4 Homo sapiens P18848
Y2H Prey Pooling
25416956
Intra
GPS2 Q13227 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 ATF5 Homo sapiens Q9Y2D1
Validated Y2H
32296183
Intra
GPS2 Q13227 ATF5 Homo sapiens Q9Y2D1
Y2H Array
32296183
Intra
GPS2 Q13227 ATF5 Homo sapiens Q9Y2D1
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
GPS2 Q13227 HDAC3 Homo sapiens O15379
Pull Down
17895379
Intra
GPS2 Q13227 HDAC3 Homo sapiens O15379
Anti Tag CoIP
33961781
Intra
GPS2 Q13227 HDAC3 Homo sapiens O15379
Anti Tag CoIP
17895379
Intra
GPS2 Q13227 SESTD1 Homo sapiens Q86VW0
Y2H Array
32296183
Intra
GPS2 Q13227 SESTD1 Homo sapiens Q86VW0
Y2H Prey Pooling
25416956
Intra
GPS2 Q13227 SESTD1 Homo sapiens Q86VW0
Validated Y2H
25416956
Intra
GPS2 Q13227 SESTD1 Homo sapiens Q86VW0
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 SESTD1 Homo sapiens Q86VW0
Validated Y2H
32296183
Intra
GPS2 Q13227 SESTD1 Homo sapiens Q86VW0
Y2H Array
25416956
Intra
GPS2 Q13227 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra
GPS2 Q13227 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
GPS2 Q13227 RBPMS Homo sapiens Q93062
Y2H Prey Pooling
25416956
Intra
GPS2 Q13227 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra
GPS2 Q13227 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
GPS2 Q13227 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 TRIP6 Homo sapiens Q15654
Validated Y2H
32296183
Intra
GPS2 Q13227 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra
GPS2 Q13227 INTS11 Homo sapiens Q5TA45
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 INTS11 Homo sapiens Q5TA45
Validated Y2H
32296183
Intra
GPS2 Q13227 INTS11 Homo sapiens Q5TA45
Y2H Array
32296183
Intra
GPS2 Q13227 MAP3K7CL Homo sapiens P57077
Y2H Pooling
16189514
Intra
GPS2 Q13227 RALBP1 Homo sapiens Q15311
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 RALBP1 Homo sapiens Q15311
Anti Tag CoIP
33961781
Intra
GPS2 Q13227 RALBP1 Homo sapiens Q15311
Validated Y2H
32296183
Intra
GPS2 Q13227 RALBP1 Homo sapiens Q15311
Y2H Array
25416956
Intra
GPS2 Q13227 RALBP1 Homo sapiens Q15311
Y2H Array
32296183
Intra
GPS2 Q13227 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 FHL5 Homo sapiens Q5TD97
Validated Y2H
32296183
Intra
GPS2 Q13227 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra
GPS2 Q13227 NCOR2 Homo sapiens Q9Y618
NMR
21240272
Intra
GPS2 Q13227 NCOR2 Homo sapiens Q9Y618
GMS
21240272
Intra
GPS2 Q13227 NCOR2 Homo sapiens Q9Y618
Anti Tag CoIP
33961781
Intra
GPS2 Q13227 NCOR2 Homo sapiens Q9Y618
Pull Down
21240272
Intra
GPS2 Q13227 POU2AF1 Homo sapiens Q16633
Validated Y2H
32296183
Intra
GPS2 Q13227 POU2AF1 Homo sapiens Q16633
Y2H Array
32296183
Intra
GPS2 Q13227 POU2AF1 Homo sapiens Q16633
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
GPS2 Q13227 KRT31 Homo sapiens Q15323
MAPPIT
25416956
Intra
GPS2 Q13227 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
GPS2 Q13227 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
GPS2 Q13227 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
GPS2 Q13227 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra
GPS2 Q13227 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Intra
GPS2 Q13227 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra
GPS2 Q13227 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Cross
GPS2 Q13227 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Pull Down
18985028
Cross
GPS2 Q13227 vif Human immunodeficiency virus P12504
Pull Down
22190034
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Liposarcoma

Lipomatous Cancer
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05758 GPS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GPS2 MGD MGI:1891751
Felis catus GPS2 VGNC VGNC:99074
Canis familiaris GPS2 VGNC VGNC:41456
Macaca mulatta GPS2 VGNC VGNC:99156
Rattus norvegicus GPS2 RGD RGD:1562746
Bos taurus GPS2 VGNC VGNC:29613