UBXN11 - UBX domain protein 11 Gene

Homo sapiens

Also known as SOC; SOCI; COA-1; UBXD5; PP2243

Gene ID: 91544 | Gene type: protein coding

About UBXN11

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,282,282-26,318,355 (from NCBI)

This gene has 16 transcripts (splice variants), 187 orthologues and 3 paralogues. Broad expression in testis (RPKM 18.9), spleen (RPKM 17.6) and 25 other tissues.

Summary

This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UBXN11 Products(5)

mRNA	Protein	Name
NM_001077262.2	NP_001070730.1	UBX domain-containing protein 11 isoform 3
NM_001389556.1	NP_001376485.1	UBX domain-containing protein 11 isoform 2
NM_001389559.1	NP_001376488.1	UBX domain-containing protein 11 isoform 1
NM_145345.3	NP_663320.2	UBX domain-containing protein 11 isoform 1
NM_183008.3	NP_892120.2	UBX domain-containing protein 11 isoform 2

UBXN11 Protein Structure

SEP

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

UBX domain-containing protein 11

UBX domain-containing protein 5

Related Diseases

Diseases

Alias

Thyroid Hurthle Cell Adenoma

Benign Oncocytoma Of The Thyroid

Thyroid Gland Oncocytic Adenoma

Peroxisome Biogenesis Disorder 2a

PBD2A	Peroxisome Biogenesis Disorder Complementation Group 2
PBD-CG2	Cg1
Pbd-Cge	Peroxisome Biogenesis Disorder Complementation Group E
Peroxisome Biogenesis Disorder, Type 2a

Colon Carcinoma In Situ

Carcinoma In Situ Of Colon	Stage 0 Colonic Carcinoma
Stage 0 Carcinoma Of Colon	Intraepithelial Neoplasia Of Colon, High Grade
Carcinoma In Situ Of Cecum	Carcinoma In Situ Of Hepatic Flexure
Carcinoma In Situ Of Ileocecal Valve	Carcinoma In Situ Of Hepatic Flexure Of Colon

Intestine Carcinoma In Situ

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15395	UBXN11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UBXN11	VGNC	VGNC:80399
Rattus norvegicus	UBXN11	RGD	RGD:620769
Bos taurus	UBXN11	VGNC	VGNC:36624
Mus musculus	UBXN11	MGD	MGI:1914836
Macaca mulatta	UBXN11	VGNC	VGNC:79859
Canis familiaris	UBXN11	VGNC	VGNC:48097

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