EIF4E2 - eukaryotic translation initiation factor 4E family member 2 Gene

Homo sapiens

Also known as 4EHP; IF4e; 4E-LP; h4EHP; EIF4EL3

Gene ID: 9470 | Gene type: protein coding

About EIF4E2

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,550,689-232,583,644 (from NCBI)

This gene has 17 transcripts (splice variants), 250 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 16.4), colon (RPKM 13.5) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in positive regulation of miRNA mediated inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. Part of mRNA cap binding activity complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF4E2 Products(7)

mRNA	Protein	Name
NM_001276336.2	NP_001263265.1	eukaryotic translation initiation factor 4E type 2 isoform C
NM_001276337.2	NP_001263266.1	eukaryotic translation initiation factor 4E type 2 isoform D
NM_001282958.2	NP_001269887.1	eukaryotic translation initiation factor 4E type 2 isoform B
NM_001330201.2	NP_001317130.1	eukaryotic translation initiation factor 4E type 2 isoform E
NM_001330202.2	NP_001317131.1	eukaryotic translation initiation factor 4E type 2 isoform G
NM_001330203.2	NP_001317132.1	eukaryotic translation initiation factor 4E type 2 isoform F
NM_004846.4	NP_004837.1	eukaryotic translation initiation factor 4E type 2 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA 7-methylguanosine cap binding	IDA IDA: Inferred from direct assay	35878012	GOA
enables mRNA cap binding	IDA IDA: Inferred from direct assay	17368478	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15094042	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	14623119	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of positive effect miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	28487484	GOA
acts upstream of or within negative regulation of translation	IMP IMP: Inferred from mutant phenotype	22751931	GOA
involved in negative regulation of translational initiation	IDA IDA: Inferred from direct assay	32726578	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	35878012	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	32726578	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	23991149	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23991149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4E2 Protein Structure

IF4E

0
100
200
245 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4E type 2

eIF-4E type 2

EIF4E2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF4E2	O60573	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
Intra	EIF4E2	O60573	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	EIF4E2	O60573	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	EIF4E2	O60573	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	EIF4E2	O60573	HOMEZ	Homo sapiens	Q8IX15-3	Validated Y2H	25416956
Intra	EIF4E2	O60573	HOMEZ	Homo sapiens	Q8IX15-3	Y2H Array	25416956
Intra	EIF4E2	O60573	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	EIF4E2	O60573	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	EIF4E2	O60573	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
Intra	EIF4E2	O60573	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	EIF4E2	O60573	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	CDR2	Homo sapiens	Q01850	Validated Y2H	25416956
Intra	EIF4E2	O60573	CDR2	Homo sapiens	Q01850	Y2H Array	25416956
Intra	EIF4E2	O60573	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	EIF4ENIF1	Homo sapiens	Q9NRA8	Anti Tag CoIP	33961781
Intra	EIF4E2	O60573	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Array	19060904
Intra	EIF4E2	O60573	EIF4ENIF1	Homo sapiens	Q9NRA8	Anti Tag CoIP	28514442
Intra	EIF4E2	O60573	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Pooling	19060904
Intra	EIF4E2	O60573	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Pooling	16189514
Intra	EIF4E2	O60573	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	EIF4E2	O60573	MYOG	Homo sapiens	P15173	Y2H Array	31515488
Intra	EIF4E2	O60573	MYOG	Homo sapiens	P15173	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	MYOG	Homo sapiens	P15173	Validated Y2H	25416956
Intra	EIF4E2	O60573	MYOG	Homo sapiens	P15173	Y2H Array	25416956
Intra	EIF4E2	O60573	ZBTB9	Homo sapiens	Q96C00	Y2H Array	31515488
Intra	EIF4E2	O60573	ZBTB9	Homo sapiens	Q96C00	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	ZBTB9	Homo sapiens	Q96C00	Validated Y2H	25416956
Intra	EIF4E2	O60573	ZBTB9	Homo sapiens	Q96C00	Y2H Array	25416956
Intra	EIF4E2	O60573	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	25416956
Intra	EIF4E2	O60573	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	SPAG5	Homo sapiens	Q96R06	Validated Y2H	25416956
Intra	EIF4E2	O60573	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	EIF4E2	O60573	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	EIF4E2	O60573	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	EIF4E2	O60573	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	EIF4E2	O60573	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	EIF4E2	O60573	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	25416956
Intra	EIF4E2	O60573	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	EIF4E2	O60573	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	EIF4E2	O60573	MAPRE3	Homo sapiens	Q9UPY8	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	EIF4EBP1	Homo sapiens	Q13541	Anti Tag CoIP	33961781
Intra	EIF4E2	O60573	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	CBY2	Homo sapiens	Q8NA61	Validated Y2H	25416956
Intra	EIF4E2	O60573	CBY2	Homo sapiens	Q8NA61	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	TADA2A	Homo sapiens	O75478	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	UBXN11	Homo sapiens	Q5T124	Y2H Array	25416956
Intra	EIF4E2	O60573	CARD9	Homo sapiens	Q9H257	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	USP54	Homo sapiens	Q70EL1	Y2H Prey Pooling	25416956
Intra	EIF4E2	O60573	USP54	Homo sapiens	Q70EL1	Validated Y2H	25416956
Intra	EIF4E2	O60573	USP54	Homo sapiens	Q70EL1	Y2H Array	25416956
Intra	EIF4E2	O60573	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	EIF4E2	O60573	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Coffin-Siris Syndrome 2

CSS2	Mrd14
Mental Retardation, Autosomal Dominant 14	Autosomal Dominant Mental Retardation 14
Coffin-Siris Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04275	EIF4E2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EIF4E2	MGD	MGI:1914440
Rattus norvegicus	EIF4E2	RGD	RGD:1307790
Bos taurus	EIF4E2	VGNC	VGNC:28410
Macaca mulatta	EIF4E2	VGNC	VGNC:72194

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