MYADM - myeloid associated differentiation marker Gene

Homo sapiens

Also known as SB135

Gene ID: 91663 | Gene type: protein coding

About MYADM

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:53,865,628-53,876,435 (from NCBI)

This gene has 11 transcripts (splice variants), 379 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 50.4), gall bladder (RPKM 50.0) and 25 other tissues.

Summary

Involved in several processes, including negative regulation of heterotypic cell-cell adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein kinase C signaling. Located in several cellular components, including cortical actin cytoskeleton; membrane raft; and ruffle. [provided by Alliance of Genome Resources, Apr 2022]

MYADM Products(12)

mRNA	Protein	Name
NM_001020818.2	NP_001018654.1	myeloid-associated differentiation marker
NM_001020819.3	NP_001018655.1	myeloid-associated differentiation marker
NM_001020820.3	NP_001018656.1	myeloid-associated differentiation marker
NM_001020821.2	NP_001018657.1	myeloid-associated differentiation marker
NM_001290188.2	NP_001277117.1	myeloid-associated differentiation marker
NM_001290189.1	NP_001277118.1	myeloid-associated differentiation marker
NM_001290190.2	NP_001277119.1	myeloid-associated differentiation marker
NM_001290191.2	NP_001277120.1	myeloid-associated differentiation marker
NM_001290192.2	NP_001277121.1	myeloid-associated differentiation marker
NM_001290193.2	NP_001277122.1	myeloid-associated differentiation marker
NM_001290194.2	NP_001277123.1	myeloid-associated differentiation marker
NM_138373.5	NP_612382.1	myeloid-associated differentiation marker

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in cell-cell junction maintenance	IMP IMP: Inferred from mutant phenotype	23264465	GOA
involved in establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	23264465	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	23264465	GOA
involved in membrane raft organization	IMP IMP: Inferred from mutant phenotype	21325632	GOA
involved in negative regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	23264465	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23264465	GOA
involved in negative regulation of heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	23264465	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	21325632	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	21325632	GOA
involved in protein localization to plasma membrane raft	IMP IMP: Inferred from mutant phenotype	21325632	GOA
NOT involved in regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	21325632	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23264465	GOA
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	21325632	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	21325632	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23264465	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	21325632	GOA
located in ruffle	IDA IDA: Inferred from direct assay	21325632	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYADM Protein Structure

MARVEL

0
100
200
300
322 a.a.

Protein Preferred Names

Protein Names

myeloid-associated differentiation marker

myeloid upregulated protein

MYADM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MYADM	Q96S97	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	MYADM	Q96S97	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	MYADM	Q96S97	FIMP	Homo sapiens	Q96LL3	Y2H Prey Pooling	32296183
Intra	MYADM	Q96S97	FIMP	Homo sapiens	Q96LL3	Y2H Array	32296183
Intra	MYADM	Q96S97	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	MYADM	Q96S97	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	MYADM	Q96S97	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	MYADM	Q96S97	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	MYADM	Q96S97	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	MYADM	Q96S97	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	MYADM	Q96S97	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	MYADM	Q96S97	ARF6	Homo sapiens	P62330	Anti Tag CoIP	28514442
Intra	MYADM	Q96S97	ARF6	Homo sapiens	P62330	Anti Tag CoIP	33961781
Intra	MYADM	Q96S97	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	MYADM	Q96S97	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	MYADM	Q96S97	F11R	Homo sapiens	Q9Y624	Y2H Array	32296183
Intra	MYADM	Q96S97	F11R	Homo sapiens	Q9Y624	Y2H Prey Pooling	32296183
Intra	MYADM	Q96S97	F11R	Homo sapiens	Q9Y624	Validated Y2H	32296183
Intra	MYADM	Q96S97	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	MYADM	Q96S97	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	MYADM	Q96S97	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	MYADM	Q96S97	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	MYADM	Q96S97	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08868	MYADM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MYADM	VGNC	VGNC:68368
Mus musculus	MYADM	MGD	MGI:1355332
Rattus norvegicus	MYADM	RGD	RGD:727835

Name
Email *

	Sorry, but the email address you supplied was invalid.