MYADM - myeloid associated differentiation marker Gene

Homo sapiens

Also known as SB135

Gene ID: 91663 | Gene type: protein coding

About MYADM

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:53,865,628-53,876,435 (from NCBI)

This gene has 11 transcripts (splice variants), 379 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 50.4), gall bladder (RPKM 50.0) and 25 other tissues.

Summary

Involved in several processes, including negative regulation of heterotypic cell-cell adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein kinase C signaling. Located in several cellular components, including cortical actin cytoskeleton; membrane raft; and ruffle. [provided by Alliance of Genome Resources, Apr 2022]

MYADM Products(12)

mRNA	Protein	Name
NM_001020818.2	NP_001018654.1	myeloid-associated differentiation marker
NM_001020819.3	NP_001018655.1	myeloid-associated differentiation marker
NM_001020820.3	NP_001018656.1	myeloid-associated differentiation marker
NM_001020821.2	NP_001018657.1	myeloid-associated differentiation marker
NM_001290188.2	NP_001277117.1	myeloid-associated differentiation marker
NM_001290189.1	NP_001277118.1	myeloid-associated differentiation marker
NM_001290190.2	NP_001277119.1	myeloid-associated differentiation marker
NM_001290191.2	NP_001277120.1	myeloid-associated differentiation marker
NM_001290192.2	NP_001277121.1	myeloid-associated differentiation marker
NM_001290193.2	NP_001277122.1	myeloid-associated differentiation marker
NM_001290194.2	NP_001277123.1	myeloid-associated differentiation marker
NM_138373.5	NP_612382.1	myeloid-associated differentiation marker

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in cell-cell junction maintenance	IMP IMP: Inferred from mutant phenotype	23264465	GOA
involved in establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	23264465	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	23264465	GOA
involved in membrane raft organization	IMP IMP: Inferred from mutant phenotype	21325632	GOA
involved in negative regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	23264465	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23264465	GOA
involved in negative regulation of heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	23264465	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	21325632	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	21325632	GOA
involved in protein localization to plasma membrane raft	IMP IMP: Inferred from mutant phenotype	21325632	GOA
NOT involved in regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	21325632	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23264465	GOA
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	21325632	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	21325632	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23264465	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	21325632	GOA
located in ruffle	IDA IDA: Inferred from direct assay	21325632	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYADM Protein Structure

MARVEL

0
100
200
300
322 a.a.

Protein Preferred Names

Protein Names

myeloid-associated differentiation marker

myeloid upregulated protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08868	MYADM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MYADM	VGNC	VGNC:68368
Mus musculus	MYADM	MGD	MGI:1355332
Rattus norvegicus	MYADM	RGD	RGD:727835

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