ARF6 - ADP ribosylation factor 6 Gene

Homo sapiens

Gene ID: 382 | Gene type: protein coding

About ARF6

Cytogenetic location: 14q21.3 Genomic coordinates (GRCh38): 14:49,893,082-49,897,054 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 30 paralogues. Ubiquitous expression in esophagus (RPKM 54.5), colon (RPKM 38.8) and 25 other tissues.

Summary

This gene encodes a member of the human ARF gene family, which is part of the Ras superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of Phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]

ARF6 Products(1)

mRNA	Protein	Name
NM_001663.4	NP_001654.1	ADP-ribosylation factor 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein activity	IDA IDA: Inferred from direct assay	32103017	GOA
enables GDP binding	IDA IDA: Inferred from direct assay	15126638	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	10391955	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9312003	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	37461827	GOA
enables thioesterase binding	IPI IPI: Inferred from physical interaction	15509780	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cortical actin cytoskeleton organization	IDA IDA: Inferred from direct assay	10036235	GOA
involved in cortical actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	10913182	GOA
involved in endocytic recycling	IDA IDA: Inferred from direct assay	10036235	GOA
involved in positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	10036235	GOA
involved in positive regulation of mitotic cytokinetic process	IMP IMP: Inferred from mutant phenotype	17628206	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	36250347	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	27044754	GOA
involved in protein localization to cleavage furrow	IMP IMP: Inferred from mutant phenotype	16148947	GOA
involved in protein localization to endosome	IMP IMP: Inferred from mutant phenotype	21951725	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	37461827	GOA
involved in regulation of Rac protein signal transduction	IDA IDA: Inferred from direct assay	10036235	GOA
involved in regulation of filopodium assembly	IDA IDA: Inferred from direct assay	14978216	GOA
involved in ruffle assembly	IDA IDA: Inferred from direct assay	10036235	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Flemming body	IDA IDA: Inferred from direct assay	23603394	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	10913182	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	23603394	GOA
is active in cleavage furrow	IMP IMP: Inferred from mutant phenotype	16148947	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	32103017	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10391955	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	19948740	GOA
located in endosome	IDA IDA: Inferred from direct assay	20682791	GOA
located in filopodium membrane	IDA IDA: Inferred from direct assay	14978216	GOA
located in membrane	IDA IDA: Inferred from direct assay	10391955	GOA
is active in midbody	IMP IMP: Inferred from mutant phenotype	16148947	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	32103017	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10036235	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	10036235	GOA
located in ruffle	IDA IDA: Inferred from direct assay	9312003	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARF6 Protein Structure

Arf

0
100
175 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor 6

Related Diseases

Diseases

Alias

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome

Door Syndrome	Doors Syndrome
Digitorenocerebral Syndrome	Autosomal Recessive Deafness-Onychodystrophy Syndrome
Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome	DOORS
Drc Syndrome	Eronen Syndrome
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Brachydactyly Due To Absence Of Distal Phalanges
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome	Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome
Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome
Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome
Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome	Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome
Deafness, Congenital Onychodystrophy, Recessive Form	Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112473	NAV-2729	Inhibitor	98.57%	Unkown
HY-139950	Rasarfin	Inhibitor	99.57%	Unkown
HY-RS00898	ARF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARF6	VGNC	VGNC:26061
Macaca mulatta	ARF6	VGNC	VGNC:84306
Mus musculus	ARF6	MGD	MGI:99435
Canis familiaris	ARF6	VGNC	VGNC:38031
Felis catus	ARF6	VGNC	VGNC:68044
Rattus norvegicus	ARF6	RGD	RGD:621279

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