IL1RL1 - interleukin 1 receptor like 1 Gene

Homo sapiens

Also known as T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R

Gene ID: 9173 | Gene type: protein coding

About IL1RL1

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,311,563-102,352,356 (from NCBI)

This gene has 9 transcripts (splice variants), 123 orthologues and 10 paralogues. Biased expression in placenta (RPKM 51.1), kidney (RPKM 5.3) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

IL1RL1 Products(3)

mRNA	Protein	Name
NM_001282408.2	NP_001269337.1	interleukin-1 receptor-like 1 isoform 3
NM_003856.4	NP_003847.2	interleukin-1 receptor-like 1 isoform 2 precursor
NM_016232.5	NP_057316.3	interleukin-1 receptor-like 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables interleukin-33 receptor activity	IDA IDA: Inferred from direct assay	16286016	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8621446	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in interleukin-33-mediated signaling pathway	IDA IDA: Inferred from direct assay	16286016	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL1RL1 Protein Structure

I-set

Ig_2

Ig_3

TIR

0
100
200
300
400
500
556 a.a.

Protein Preferred Names

Protein Names

interleukin-1 receptor-like 1

growth stimulation-expressed

Recombinant IL1RL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70615	ST2/IL1RL1 Protein, Human (310a.a, HEK293, His)	Q01638-2 (K19-F328)	≥95%
HY-P76090	ST2/IL1RL1 Protein, Human (HEK293)	Q01638-2 (K19-F328)	≥95%
HY-P76091	ST2/IL1RL1 Protein, Human (HEK293, Fc)	Q01638-2 (K19-F328)	≥95%
HY-P76093	ST2/IL1RL1 Protein, Human (HEK293, His)	Q01638-1 (K19-S328)	≥95%

Related Diseases

Diseases

Alias

Chicken Egg Allergy

Gallus Gallus Egg Allergy

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Loeffler Syndrome

Loeffler'S Pneumonia	Loffler'S Syndrome
Simple Pulmonary Eosinophilia

Conjunctivitis

Madras Eye	Adenoviral Conjunctivitis
Acute Adenoviral Follicular Conjunctivitis	Inclusion Conjunctivitis Of The Adult
Swimming-Pool Conjunctivitis	Inflammation Of Conjunctiva
Ophthalmia	Acute Conjunctivitis
Eye Catarrh	Catarrhal Ophthalmia
Koch-Weeks Conjunctivitis

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Chronic Asthma

Pneumothorax, Primary Spontaneous

Primary Spontaneous Pneumothorax	Spontaneous Pneumothorax
Familial Spontaneous Pneumothorax	PSP
Pneumothorax

Intrinsic Asthma

Non-Atopic Asthma

Respiratory Allergy

Airway Allergy

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Parasitic Helminthiasis Infectious Disease

Helminthiasis	Intestinal Helminthiasis
Helminth Infection	Helminthosis
Worm Infection	Worm Infections
Helminth Infections	Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata
Parasitic Enteritis	Metazoal Dysentery
Intestinal Worms Nos

Nasal Cavity Disease

Disorder Of Nasal Cavity

Nose Disease

Nose Diseases	Disorder Of The Nose
Nasal Disorder	Abnormality Of The Nose

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99729	Melrilimab	Inhibitor	96.07%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06725	IL1RL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IL1RL1	VGNC	VGNC:73721
Bos taurus	IL1RL1	VGNC	VGNC:30134
Felis catus	IL1RL1	VGNC	VGNC:67768
Rattus norvegicus	IL1RL1	RGD	RGD:2894
Canis familiaris	IL1RL1	VGNC	VGNC:41961
Mus musculus	IL1RL1	MGD	MGI:98427
Macaca fascicularis	IL1RL1	NCBI	NCBI:102115135
Others	IL1RL1	NCBI

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