2. Gene
  3. IL1RL1 - interleukin 1 receptor like 1 Gene

IL1RL1 - interleukin 1 receptor like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R

Gene ID: 9173 | Gene type: protein coding

About IL1RL1

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,311,563-102,352,356 (from NCBI)

This gene has 9 transcripts (splice variants), 123 orthologues and 10 paralogues. Biased expression in placenta (RPKM 51.1), kidney (RPKM 5.3) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

IL1RL1 Products(3)

mRNA Protein Name
NM_001282408.2 NP_001269337.1 interleukin-1 receptor-like 1 isoform 3
NM_003856.4 NP_003847.2 interleukin-1 receptor-like 1 isoform 2 precursor
NM_016232.5 NP_057316.3 interleukin-1 receptor-like 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables interleukin-33 receptor activity IDA
IDA: Inferred from direct assay
16286016 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8621446 GOA
Biological Process GO Annotation Evidence Reference Source
involved in interleukin-33-mediated signaling pathway IDA
IDA: Inferred from direct assay
16286016 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL1RL1 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (28 - 103)

Ig_2

Ig_2: Immunoglobulin domain (141 - 201)

Ig_3

Ig_3: Immunoglobulin domain (212 - 307)

TIR

TIR: TIR domain (379 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 556 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-like 1

growth stimulation-expressed

IL1RL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IL1RL1 Q01638 CLEC7A Homo sapiens Q9BXN2
Validated Y2H
25416956
Intra
IL1RL1 Q01638 CLEC7A Homo sapiens Q9BXN2
Y2H Array
25416956
Intra
IL1RL1 Q01638 IL33 Homo sapiens O95760
Pull Down
16286016
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL1RL1 Proteins

Cat. No. Product Name Accession Purity
HY-P70615 ST2/IL1RL1 Protein, Human (310a.a, HEK293, His) Q01638-2 (K19-F328) ≥95%
HY-P76090 ST2/IL1RL1 Protein, Human (HEK293) Q01638-2 (K19-F328) ≥95%
HY-P76091 ST2/IL1RL1 Protein, Human (HEK293, Fc) Q01638-2 (K19-F328) ≥95%
HY-P76093 ST2/IL1RL1 Protein, Human (HEK293, His) Q01638-1 (K19-S328) ≥95%

Related Diseases

Diseases Alias
Chicken Egg Allergy

Gallus Gallus Egg Allergy
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Loeffler Syndrome

Loeffler'S Pneumonia

Loffler'S Syndrome

Simple Pulmonary Eosinophilia
Conjunctivitis

Madras Eye

Adenoviral Conjunctivitis

Acute Adenoviral Follicular Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Swimming-Pool Conjunctivitis

Inflammation Of Conjunctiva

Ophthalmia

Acute Conjunctivitis

Eye Catarrh

Catarrhal Ophthalmia

Koch-Weeks Conjunctivitis
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood
Chronic Asthma
Pneumothorax, Primary Spontaneous

Primary Spontaneous Pneumothorax

Spontaneous Pneumothorax

Familial Spontaneous Pneumothorax

PSP

Pneumothorax
Intrinsic Asthma

Non-Atopic Asthma
Respiratory Allergy

Airway Allergy
Bronchial Disease

Bronchial Diseases

Bronchial Disorders

Bronchial Spasm
Parasitic Helminthiasis Infectious Disease

Helminthiasis

Intestinal Helminthiasis

Helminth Infection

Helminthosis

Worm Infection

Worm Infections

Helminth Infections

Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata

Parasitic Enteritis

Metazoal Dysentery

Intestinal Worms Nos
Nasal Cavity Disease

Disorder Of Nasal Cavity
Nose Disease

Nose Diseases

Disorder Of The Nose

Nasal Disorder

Abnormality Of The Nose
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99729 Melrilimab Inhibitor 96.07% Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06725 IL1RL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta IL1RL1 VGNC VGNC:73721
Bos taurus IL1RL1 VGNC VGNC:30134
Felis catus IL1RL1 VGNC VGNC:67768
Rattus norvegicus IL1RL1 RGD RGD:2894
Canis familiaris IL1RL1 VGNC VGNC:41961
Mus musculus IL1RL1 MGD MGI:98427
Macaca fascicularis IL1RL1 NCBI NCBI:102115135
Others IL1RL1 NCBI