2. Gene
  3. CAMK2B - calcium/calmodulin dependent protein kinase II beta Gene

CAMK2B - calcium/calmodulin dependent protein kinase II beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAM2; CAMK2; CAMKB; MRD54; CaMKIIbeta

Gene ID: 816 | Gene type: protein coding

About CAMK2B

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,217,154-44,326,013 (from NCBI)

This gene has 49 transcripts (splice variants), 255 orthologues, 22 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 44.0), heart (RPKM 16.4) and 2 other tissues.

Summary

The product of this gene belongs to the serine/threonine protein kinase family and to the CA(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the Enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with Calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

CAMK2B Products(9)

mRNA Protein Name
NM_001220.5 NP_001211.3 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1
NM_001293170.2 NP_001280099.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2
NM_172078.3 NP_742075.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2
NM_172079.3 NP_742076.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3
NM_172080.3 NP_742077.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 4
NM_172081.3 NP_742078.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 5
NM_172082.3 NP_742079.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 6
NM_172083.3 NP_742080.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 7
NM_172084.3 NP_742081.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 8
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: Inferred from direct assay
31930741 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
20668654 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20668654 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
20668654 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
18817731 GOA
involved in regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
29100089 GOA
Cellular Component GO Annotation Evidence Reference Source
part of calcium- and calmodulin-dependent protein kinase complex IDA
IDA: Inferred from direct assay
20668654 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK2B Protein Structure

Pkinase

Pkinase: Protein kinase domain (14 - 272)

CaMKII_AD

CaMKII_AD: Calcium/calmodulin dependent protein kinase II association domain (534 - 661)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type II subunit beta

CaM kinase II beta subunit

CAMK2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CAMK2B Q13554 b3kwq7_human Homo sapiens B3KWQ7
Y2H Array
25416956
Intra
CAMK2B Q13554 b3kwq7_human Homo sapiens B3KWQ7
Validated Y2H
25416956
Intra
CAMK2B Q13554 b3kwq7_human Homo sapiens B3KWQ7
Y2H Prey Pooling
25416956
Intra
CAMK2B Q13554 KRTAP10-11 Homo sapiens P60412
Y2H Prey Pooling
25416956
Intra
CAMK2B Q13554 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
25416956
Intra
CAMK2B Q13554 SPRYD7 Homo sapiens Q5W111
Validated Y2H
25416956
Intra
CAMK2B Q13554 SPRYD7 Homo sapiens Q5W111
Y2H Array
25416956
Intra
CAMK2B Q13554 FAM171A2 Homo sapiens Q8N0U1
Y2H Array
25416956
Intra
CAMK2B Q13554 FAM171A2 Homo sapiens Q8N0U1
Validated Y2H
25416956
Intra
CAMK2B Q13554 MORF4L1 Homo sapiens Q9UBU8-2
Y2H Prey Pooling
25416956
Intra
CAMK2B Q13554 MORF4L1 Homo sapiens Q9UBU8-2
Y2H Array
25416956
Intra
CAMK2B Q13554 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
25416956
Intra
CAMK2B Q13554 AP5B1 Homo sapiens Q2VPB7
Validated Y2H
25416956
Intra
CAMK2B Q13554 CAMK2B Homo sapiens Q13554
Solution Sedimentation
20668654
Intra
CAMK2B Q13554 AP5B1 Homo sapiens Q2VPB7
Y2H Array
25416956
Intra
CAMK2B Q13554 CAMK2A Homo sapiens Q9UQM7
Anti Tag CoIP
29426014
Intra
CAMK2B Q13554 CAMK2B Homo sapiens Q13554
Y2H Array
25416956
Intra
CAMK2B Q13554 CAMK2D Homo sapiens Q13557
Pull Down
32707033
Intra
CAMK2B Q13554 CAMK2D Homo sapiens Q13557
Anti Tag CoIP
29426014
Intra
CAMK2B Q13554 CAMK2D Homo sapiens Q13557
Solution Sedimentation
20668654
Intra
CAMK2B Q13554 RPL11 Homo sapiens P62913
Validated Y2H
25416956
Intra
CAMK2B Q13554 RPL11 Homo sapiens P62913
Y2H Prey Pooling
25416956
Intra
CAMK2B Q13554 POP5 Homo sapiens Q969H6
Y2H Prey Pooling
25416956
Intra
CAMK2B Q13554 MED18 Homo sapiens Q9BUE0
Y2H Array
25416956
Intra
CAMK2B Q13554 MED18 Homo sapiens Q9BUE0
Validated Y2H
25416956
Intra
CAMK2B Q13554 MORF4L1 Homo sapiens Q9UBU8
Y2H Array
25416956
Intra
CAMK2B Q13554 MRPL11 Homo sapiens Q9Y3B7
Validated Y2H
25416956
Intra
CAMK2B Q13554 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra
CAMK2B Q13554 RBFOX2 Homo sapiens O43251
Y2H Prey Pooling
25416956
Intra
CAMK2B Q13554 RBFOX2 Homo sapiens O43251
Validated Y2H
25416956
Intra
CAMK2B Q13554 RAP2B Homo sapiens P61225
Y2H Prey Pooling
25416956
Intra
CAMK2B Q13554 RAP2B Homo sapiens P61225
Validated Y2H
25416956
Intra
CAMK2B Q13554 MAD2L2 Homo sapiens Q9UI95
Y2H Prey Pooling
25416956
Intra
CAMK2B Q13554 SEMA4G Homo sapiens Q9NTN9-3
Y2H Prey Pooling
25416956
Intra
CAMK2B Q13554 ACOT7 Homo sapiens O00154
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAMK2B Proteins

Cat. No. Product Name Accession Purity
HY-P76762 CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) Q13554-3 (M1-Q503) ≥95%

CAMK2B Antibodies

Cat. No. Product Name Application Reactivity
HY-P82599 CaMKII beta Antibody (YA2344) WB Mouse

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 54

Mental Retardation, Autosomal Dominant 54

MRD54

Autosomal Dominant Intellectual Developmental Disorder 54

Autosomal Dominant Mental Retardation 54
Autosomal Dominant Non-Syndromic Intellectual Disability
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes

ASGD5

Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01857 CAMK2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CAMK2B VGNC VGNC:26722
Rattus norvegicus CAMK2B RGD RGD:2262
Macaca mulatta CAMK2B VGNC VGNC:70524
Mus musculus CAMK2B MGD MGI:88257
Felis catus CAMK2B VGNC VGNC:60332
Others CAMK2B NCBI