AIMP1 - aminoacyl tRNA synthetase complex interacting multifunctional protein 1 Gene

Homo sapiens

Also known as p43; HLD3; EMAP2; SCYE1; EMAPII

Gene ID: 9255 | Gene type: protein coding

About AIMP1

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:106,315,544-106,349,456 (from NCBI)

This gene has 19 transcripts (splice variants), 306 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 9.6), prostate (RPKM 7.6) and 25 other tissues.

Summary

The protein encoded by this gene is a cytokine that is specifically induced by Apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

AIMP1 Products(3)

mRNA	Protein	Name
NM_001142415.2	NP_001135887.1	aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor
NM_001142416.2	NP_001135888.2	aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor
NM_004757.4	NP_004748.2	aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	24337748	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11741979	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11306575	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	11306575	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	11741979	GOA
involved in leukocyte migration	IDA IDA: Inferred from direct assay	11306575	GOA
involved in negative regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	11741979	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of aminoacyl-tRNA synthetase multienzyme complex	IDA IDA: Inferred from direct assay	10791971	GOA
located in cell surface	IDA IDA: Inferred from direct assay	11741979	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19289464	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AIMP1 Protein Structure

tRNA_bind

0
100
200
312 a.a.

Protein Preferred Names

Protein Names

aminoacyl tRNA synthase complex-interacting multifunctional protein 1

ARS-interacting multifunctional protein 1

AIMP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AIMP1	Q12904	TSNAX	Homo sapiens	Q99598	Validated Y2H	25416956
Intra	AIMP1	Q12904	AIMP2	Homo sapiens	Q13155	Anti Tag CoIP	33961781
Intra	AIMP1	Q12904	AIMP2	Homo sapiens	Q13155	Anti Tag CoIP	28514442
Intra	AIMP1	Q12904	AIMP2	Homo sapiens	Q13155	Y2H Array	25416956
Cross	AIMP1	Q12904	P04591-PRO_0000038593	Human immunodeficiency virus	P04591-PRO_0000038593	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AIMP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7156	EMAP-II Protein, Human	Q12904 (S147-K312)	≥95%

Related Diseases

Diseases

Alias

Leukodystrophy, Hypomyelinating, 3

Hypomyelinating Leukodystrophy 3	HLD3
Pelizaeus-Merzbacher-Like Disease Due To Aimp1 Mutation	Leukodystrophy, Hypomyelinating 3
Perinatal Sudanophilic Leukodystrophy	Leukodystrophy, Hypomyelinating, Type 3
Pelizaeus-Merzbacher-Like Disease, Autosomal Recessive, 2

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Hypotonia

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Leukodystrophy, Hypomyelinating, 7, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism

HLD7	Leukoencephalopathy-Ataxia-Hypodontia-Hypomyelination Syndrome
Addh	Leukodystrophy, Hypomyelinating, With Hypodontia And Hypogonadotropic Hypogonadism
4h Syndrome	4h Leukodystrophy 1
Hypomyelinating Leukodystrophy 7 With Or Without Oligodontia And-Or Hypogonadotropic Hypogonadism	Hypomyelination-Cerebellar Atrophy-Hypoplasia Of The Corpus Callosum Syndrome
Leukodystrophy With Oligodontia	Tach Syndrome
Tremor-Ataxia-Central Hypomyelination Syndrome	Leukoencephalopathy, Hypomyelinating, With Ataxia And Delayed Dentition
Ataxia, Delayed Dentition, And Hypomyelination	Ataxia-Delayed Dentition-Hypomyelination Syndrome
Odontoleukodystrophy	Dentoleukoencephalopathy
Hypomyelinating Leukodystrophy-Ataxia-Hypodontia-Hypomyelination Syndrome	Ataxia-Delayed Dentition-Hypomyelination Syndrome
Ataxia Delayed Dentition And Hypomyelination	Leukodystrophy Hypomyelinating With Hypodontia And Hypogonadotropic Hypogonadism 4h Syndrome
Leukoencephalopathy Hypomyelinating With Ataxia And Delayed Dentition	Tach
Tremor-Ataxia With Central Hypomyelination	Attention Deficit Hyperactivity Disorder
Leukodystrophy, Dysmyelinating, With Oligodontia

Leukodystrophy, Hypomyelinating, 9

Hypomyelinating Leukodystrophy 9	HLD9
Rars-Related Autosomal Recessive Hypomyelinating Leukodystrophy	Leukodystrophy, Hypomyelinating, Type 9

Leukodystrophy

Leukodystrophies

Charcot-Marie-Tooth Disease, Dominant Intermediate C

CMTDIC	Charcot-Marie-Tooth Disease Dominant Intermediate C
Di-Cmtc	Autosomal Dominant Intermediate Charcot-Marie-Tooth Disease Type C
Charcot-Marie-Tooth Neuropathy, Dominant Intermediate C	Charcot-Marie-Tooth Neuropathy Dominant Intermediate C
Charcot-Marie-Tooth Disease, Dominant, Intermediate Type, C	Charcot-Marie-Tooth Disease, Dominant Intermediate, Type C

Pelizaeus-Merzbacher Disease

PMD	HLD1
Pelizaeus-Merzbacher Brain Sclerosis	Leukodystrophy, Hypomyelinating, 1
Diffuse Familial Brain Sclerosis	Pelizaeus Merzbacher Brain Sclerosis
Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type	Cockayne-Pelizaeus-Merzbacher Disease
Hypomyelinating Leukodystrophy 1	Leukodystrophy, Sudanophilic
Pelizaeus Merzbacher Disease	Hypomyelinating Leukodystrophy, 1
Sudanophilic Leukodystrophy	Pelizaeus-Merzbacher Disease, Connatal Form
Connatal Pmd	Pelizaeus-Merzbacher Disease Type Ii
Severe Pmd	Null Syndrome
Plp1 Null Syndrome	Pelizaeus-Merzbacher Disease, Null Syndrome
Brain Sclerosis Diffuse Familial	Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type
Leukodystrophy Hypomyelinating 1	Diffuse Cerebral Sclerosis Of Schilder

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00497	AIMP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AIMP1	VGNC	VGNC:25765
Rattus norvegicus	AIMP1	RGD	RGD:620466
Felis catus	AIMP1	VGNC	VGNC:78451
Canis familiaris	AIMP1	VGNC	VGNC:103659
Macaca mulatta	AIMP1	VGNC	VGNC:69599
Mus musculus	AIMP1	MGD	MGI:102774
Others	AIMP1	NCBI

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