SOCS6 - suppressor of cytokine signaling 6 Gene

Homo sapiens

Also known as CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060

Gene ID: 9306 | Gene type: protein coding

About SOCS6

Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:70,289,045-70,330,199 (from NCBI)

This gene has 3 transcripts (splice variants), 226 orthologues and 7 paralogues. Ubiquitous expression in small intestine (RPKM 4.2), colon (RPKM 3.9) and 25 other tissues.

Summary

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT Inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT Inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

SOCS6 Products(1)

mRNA	Protein	Name
NM_004232.4	NP_004223.2	suppressor of cytokine signaling 6

SOCS6 Protein Structure

SH2

SOCS_box

0
100
200
300
400
500
535 a.a.

Protein Preferred Names

Protein Names

suppressor of cytokine signaling 6

STAT induced STAT inhibitor-4

SOCS6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SOCS6	O14544	MET	Homo sapiens	P08581	FPS	24728074
Intra	SOCS6	O14544	YAP1	Homo sapiens	P46937	Anti Bait CoIP	25180228
Intra	SOCS6	O14544	YAP1	Homo sapiens	P46937	Anti Tag CoIP	25180228
Intra	SOCS6	O14544	KIT	Homo sapiens	P10721	FPS	24728074
Intra	SOCS6	O14544	ERN1	Homo sapiens	O75460-2	Y2H Array	32814053
Intra	SOCS6	O14544	ERN1	Homo sapiens	O75460-2	Validated Y2H	32814053
Intra	SOCS6	O14544	ERN1	Homo sapiens	O75460-2	Y2H Pooling	32814053
Intra	SOCS6	O14544	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	SOCS6	O14544	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	SOCS6	O14544	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	SOCS6	O14544	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	SOCS6	O14544	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	SOCS6	O14544	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	SOCS6	O14544	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	SOCS6	O14544	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	SOCS6	O14544	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	SOCS6	O14544	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	SOCS6	O14544	AR	Homo sapiens	P10275	FPS	24728074
Intra	SOCS6	O14544	ARIH2	Homo sapiens	O95376	Anti Tag CoIP	33961781
Intra	SOCS6	O14544	ARIH2	Homo sapiens	O95376	Anti Tag CoIP	28514442
Intra	SOCS6	O14544	TXK	Homo sapiens	P42681	Validated Y2H	32296183
Intra	SOCS6	O14544	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Somatization Disorder

Somatoform Disorders	Briquet'S Disorder
Polysomatising Disorder	Somatisation Disorder
Somatoform Disorder

Articulation Disorder

Phonological Disorder	Articulation Disorders
Articulation Impairment	Speech Sound Disorders

Speech Disorder

Speech Disorders

Stuttering

Stammering	Familial Persistent Stuttering
Stuttering, Familial Persistent 1

Myelofibrosis

Primary Myelofibrosis	Agnogenic Myeloid Metaplasia
Idiopathic Myelofibrosis	Myeloid Metaplasia
Myelofibrosis With Myeloid Metaplasia	Osteomyelofibrosis
Megakaryocytic Myelosclerosis	Myelosclerosis
Chronic Idiopathic Myelofibrosis	Myelofibrosis, Idiopathic
Myelofibrosis With Myeloid Metaplasia, Somatic	Myelofibrosis, Somatic
Aleukemic Myelosis	Bone Marrow Fibrosis
MYELOF	MMM
Agnogenic Myeloid Metaplasia With Myelofibrosis	Ammm
Myelosclerosis With Myeloid Metaplasia	Myelofibrosis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13557	SOCS6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SOCS6	VGNC	VGNC:81577
Bos taurus	SOCS6	VGNC	VGNC:35124
Mus musculus	SOCS6	MGD	MGI:1924885
Canis familiaris	SOCS6	VGNC	VGNC:56921
Rattus norvegicus	SOCS6	RGD	RGD:1304632
Felis catus	SOCS6	VGNC	VGNC:65565

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