2. Gene
  3. TXK - TXK tyrosine kinase Gene

TXK - TXK tyrosine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RLK; TKL; BTKL; PTK4; PSCTK5

Gene ID: 7294 | Gene type: protein coding

About TXK

Cytogenetic location: 4p12 Genomic coordinates (GRCh38): 4:48,066,393-48,134,250 (from NCBI)

This gene has 6 transcripts (splice variants), 117 orthologues and 32 paralogues. Broad expression in lymph node (RPKM 5.7), spleen (RPKM 3.3) and 15 other tissues.

Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein autophosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TXK Products(1)

mRNA Protein Name
NM_003328.3 NP_003319.2 tyrosine-protein kinase TXK
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17177976 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11859127 GOA
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
10523612 GOA
involved in positive regulation of type II interferon-mediated signaling pathway IDA
IDA: Inferred from direct assay
11859127 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
12081135 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
17177976 GOA
involved in regulation of gene expression IDA
IDA: Inferred from direct assay
11859127 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10523612 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10523612 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TXK Protein Structure

SH3_1

SH3_1: SH3 domain (88 - 134)

SH2

SH2: SH2 domain (150 - 231)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (272 - 518)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 527 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase TXK

PTK4 protein tyrosine kinase 4

TXK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TXK P42681 ZNF792 Homo sapiens Q3KQV3
Validated Y2H
32296183
Intra TXK P42681 ZNF792 Homo sapiens Q3KQV3
Y2H Array
32296183
Intra TXK P42681 ZNF792 Homo sapiens Q3KQV3
Y2H Prey Pooling
32296183
Intra TXK P42681 DOK2 Homo sapiens O60496
Y2H Prey Pooling
32296183
Intra TXK P42681 DOK2 Homo sapiens O60496
Y2H Array
32296183
Intra TXK P42681 IKZF1 Homo sapiens Q13422-7
Validated Y2H
32296183
Intra TXK P42681 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra TXK P42681 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra TXK P42681 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
Intra TXK P42681 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra TXK P42681 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
32296183
Intra TXK P42681 RBAK Homo sapiens Q9NYW8
Validated Y2H
32296183
Intra TXK P42681 RBAK Homo sapiens Q9NYW8
Y2H Array
32296183
Intra TXK P42681 RBAK Homo sapiens Q9NYW8
Y2H Prey Pooling
32296183
Intra TXK P42681 GRB10 Homo sapiens Q13322-4
Validated Y2H
32296183
Intra TXK P42681 GRB10 Homo sapiens Q13322-4
Y2H Prey Pooling
32296183
Intra TXK P42681 GRB10 Homo sapiens Q13322-4
Y2H Array
32296183
Intra TXK P42681 KIT Homo sapiens P10721
FPS
24728074
Intra TXK P42681 STAP2 Homo sapiens Q9UGK3
Y2H Array
32296183
Intra TXK P42681 STAP2 Homo sapiens Q9UGK3
Validated Y2H
32296183
Intra TXK P42681 STAP2 Homo sapiens Q9UGK3
Y2H Prey Pooling
32296183
Intra TXK P42681 IKZF4 Homo sapiens Q9H2S9
Validated Y2H
32296183
Intra TXK P42681 IKZF4 Homo sapiens Q9H2S9
Y2H Array
32296183
Intra TXK P42681 IKZF4 Homo sapiens Q9H2S9
Y2H Prey Pooling
32296183
Intra TXK P42681 JRK Homo sapiens O75564-2
Y2H Array
32296183
Intra TXK P42681 JRK Homo sapiens O75564-2
Y2H Prey Pooling
32296183
Intra TXK P42681 EFHC2 Homo sapiens Q5JST6
Validated Y2H
32296183
Intra TXK P42681 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra TXK P42681 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra TXK P42681 SOCS6 Homo sapiens O14544
Y2H Array
32296183
Intra TXK P42681 SOCS6 Homo sapiens O14544
Y2H Prey Pooling
32296183
Intra TXK P42681 PRDM14 Homo sapiens Q9GZV8
Y2H Array
32296183
Intra TXK P42681 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
32296183
Intra TXK P42681 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
32296183
Intra TXK P42681 GRB2 Homo sapiens P62993
Validated Y2H
32296183
Intra TXK P42681 ZNF835 Homo sapiens Q9Y2P0
Y2H Array
32296183
Intra TXK P42681 ZNF835 Homo sapiens Q9Y2P0
Y2H Prey Pooling
32296183
Intra TXK P42681 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra TXK P42681 ZNF587 Homo sapiens Q96SQ5
Y2H Prey Pooling
32296183
Intra TXK P42681 ZNF587 Homo sapiens Q96SQ5
Y2H Array
32296183
Intra TXK P42681 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra TXK P42681 NCK2 Homo sapiens O43639
Y2H Prey Pooling
32296183
Intra TXK P42681 NCK2 Homo sapiens O43639
Y2H Array
32296183
Intra TXK P42681 SOCS3 Homo sapiens O14543
Y2H Array
32296183
Intra TXK P42681 SOCS3 Homo sapiens O14543
Y2H Prey Pooling
32296183
Intra TXK P42681 DUSP6 Homo sapiens Q16828
Validated Y2H
32296183
Intra TXK P42681 DUSP6 Homo sapiens Q16828
Y2H Array
32296183
Intra TXK P42681 DUSP6 Homo sapiens Q16828
Y2H Prey Pooling
32296183
Intra TXK P42681 TNS4 Homo sapiens Q8IZW8
Validated Y2H
32296183
Intra TXK P42681 TNS4 Homo sapiens Q8IZW8
Y2H Array
32296183
Intra TXK P42681 TNS4 Homo sapiens Q8IZW8
Y2H Prey Pooling
32296183
Intra TXK P42681 CRK Homo sapiens P46108
Y2H Prey Pooling
32296183
Intra TXK P42681 CRK Homo sapiens P46108
Validated Y2H
32296183
Intra TXK P42681 CRK Homo sapiens P46108
Y2H Array
32296183
Intra TXK P42681 PIK3R1 Homo sapiens P27986-2
Y2H Prey Pooling
32296183
Intra TXK P42681 PIK3R1 Homo sapiens P27986-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Agammaglobulinemia

Hypogammaglobulinemia

Ighm

Mu Heavy Chain Deficiency

Mu-Heavy Chain Disease

Mu-Hcd

Mu-Chain Disease
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
Agammaglobulinemia, X-Linked

X-Linked Agammaglobulinemia

XLA

Bruton Type Agammaglobulinemia

Bruton'S Agammaglobulinemia

Bruton-Type Agammaglobulinemia

Agmx1

Imd1

Agammaglobulinemia, X-Linked 1

Btk-Deficiency

Agammaglobulinemia

Hypogammaglobulinemia

Agammaglobulinemia, X-Linked, Type 1

Immunodeficiency 1

Bruton Agammaglobulinemia Tyrosine Kinase Deficiency

Bruton Disease

Bruton'S Agammaglobulinaemia

Bruton'S Sex-Linked Agammaglobulinemia

Bruton'S Type Agammaglobulinemia

Btk Deficiency

Agammaglobulinemia, Btk

Agammaglobulinemia, Bruton Tyrosine Kinase

Congenital Agammaglobulinemia

Immunodeficiency Type 1

X-Linked Agammaglobulinemia Type 1
Immunodeficiency 17

IMD17

Cd3-Gamma Deficiency

Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive

Combined Immunodeficiency Due To Cd3gamma Deficiency

Immunodeficiency 17, Cd3 Gamma Deficient

Cd3gamma Deficiency

Immunodeficiency, Type 17
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10644 Lck inhibitor 2 Inhibitor 99.81% Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-RS15285 TXK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-D2415 BODIPY-FL staurosporine / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TXK VGNC VGNC:48005
Bos taurus TXK VGNC VGNC:36529
Mus musculus TXK MGD MGI:102960
Felis catus TXK VGNC VGNC:66719
Macaca mulatta TXK VGNC VGNC:78678
Rattus norvegicus TXK RGD RGD:1306481
Others TXK NCBI