2. Gene
  3. DMKN - dermokine Gene

DMKN - dermokine Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as UNQ729; ZD52F10

Gene ID: 93099 | Gene type: protein coding

About DMKN

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,497,220-35,513,649 (from NCBI)

This gene has 68 transcripts (splice variants) and 64 orthologues. Biased expression in skin (RPKM 387.3) and esophagus (RPKM 47.0).

Summary

This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

DMKN Products(16)

mRNA Protein Name
NM_001035516.4 NP_001030593.2 dermokine isoform 1 precursor
NM_001126056.3 NP_001119528.3 dermokine isoform 3 precursor
NM_001126057.3 NP_001119529.2 dermokine isoform 5 precursor
NM_001126058.3 NP_001119530.2 dermokine isoform 4 precursor
NM_001126059.4 NP_001119531.2 dermokine isoform 6
NM_001190347.2 NP_001177276.2 dermokine isoform 8 precursor
NM_001190348.2 NP_001177277.1 dermokine isoform 9 precursor
NM_001190349.2 NP_001177278.1 dermokine isoform 10 precursor
NM_001308380.2 NP_001295309.2 dermokine isoform 11
NM_001308383.2 NP_001295312.2 dermokine isoform 12
NM_001352328.2 NP_001339257.2 dermokine isoform 13
NM_001352329.2 NP_001339258.2 dermokine isoform 14
NM_001352330.2 NP_001339259.2 dermokine isoform 14
NM_001352331.2 NP_001339260.1 dermokine isoform 15
NM_001352332.2 NP_001339261.1 dermokine isoform 16
NM_033317.5 NP_201574.4 dermokine isoform 2 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22735594 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dermokine

epidermis-specific secreted protein SK30/SK89

DMKN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DMKN Q6E0U4 HSPA5 Homo sapiens P11021
Crosslink
22735594
Intra
DMKN Q6E0U4 HSPA5 Homo sapiens P11021
Competition Binding
22735594
Intra
DMKN Q6E0U4 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
DMKN Q6E0U4 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
DMKN Q6E0U4 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
DMKN Q6E0U4 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
DMKN Q6E0U4 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
DMKN Q6E0U4 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
DMKN Q6E0U4 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
DMKN Q6E0U4 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
DMKN Q6E0U4 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03825 DMKN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DMKN VGNC VGNC:28107
Macaca mulatta DMKN VGNC VGNC:71903
Canis familiaris DMKN VGNC VGNC:40000
Rattus norvegicus DMKN RGD RGD:1561521
Mus musculus DMKN MGD MGI:1920962