TRIP10 - thyroid hormone receptor interactor 10 Gene

Homo sapiens

Also known as STP; CIP4; HSTP; STOT; TRIP-10

Gene ID: 9322 | Gene type: protein coding

About TRIP10

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,739,680-6,751,530 (from NCBI)

This gene has 13 transcripts (splice variants), 253 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 54.6), fat (RPKM 34.4) and 22 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in actin Cytoskeleton organization; endocytosis; and signal transduction. Located in nucleoplasm. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Apr 2022]

TRIP10 Products(3)

mRNA	Protein	Name
NM_001288962.2	NP_001275891.1	cdc42-interacting protein 4 isoform 1
NM_001288963.3	NP_001275892.1	cdc42-interacting protein 4 isoform 3
NM_004240.4	NP_004231.1	cdc42-interacting protein 4 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17512409	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16318909	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIP10 Protein Structure

FCH

SH3_1

0
100
200
300
400
500
601 a.a.

Protein Preferred Names

Protein Names

cdc42-interacting protein 4

TR-interacting protein 10

Recombinant TRIP10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76260	TRIP10/CIP4 Protein, Human (sf9, His)	Q15642 (M1-N545)	≥95%

Related Diseases

Diseases

Alias

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive	Autosomal Recessive Centronuclear Myopathy
CNM2	Centronuclear Myopathy 2
Ar-Cnm	Myotubular Myopathy, Autosomal Recessive
Autosomal Recessive Myotubular Myopathy	Centronuclear Myopathy Autosomal Recessive
Myopathy, Centronuclear, Type 2

Hypochondriasis

Hypochondriacal Disorder	Hypochondria
Hypochondriacal Neurosis	Illness Anxiety Disorder
Health Anxiety Disorder	Hypochondriacal Reaction

Chronic Recurrent Multifocal Osteomyelitis

Chronic Multifocal Osteomyelitis	CRMO
Cmo	Cno/Crmo
Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis	Osteomyelitis, Chronic Multifocal
Multifocal Osteomyelitis, Chronic	Chronic Osteomyelitis
Chronic Multifocal Osteomyelitis, Unspecified Site	Crmo - [Chronic Multifocal Osteomyelitis]
Chronic Osteomyelitis With Draining Sinus, Unspecified Site	Bone Fistula With Chronic Osteomyelitis

Familial Hypocalciuric Hypercalcemia

Familial Benign Hypercalcemia	Fbh
Fbhh	Fhh
Familial Benign Hypocalciuric Hypercalcemia	Hypocalciuric Hypercalcemia, Familial, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15076	TRIP10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIP10	MGD	MGI:2146901
Canis familiaris	TRIP10	VGNC	VGNC:47844
Macaca mulatta	TRIP10	VGNC	VGNC:78646
Bos taurus	TRIP10	VGNC	VGNC:106998
Rattus norvegicus	TRIP10	RGD	RGD:621145
Felis catus	TRIP10	VGNC	VGNC:66558
Others	TRIP10	NCBI

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