RHOJ - ras homolog family member J Gene

Homo sapiens

Also known as TCL; ARHJ; TC10B; RASL7B

Gene ID: 57381 | Gene type: protein coding

About RHOJ

Cytogenetic location: 14q23.2 Genomic coordinates (GRCh38): 14:63,204,443-63,293,508 (from NCBI)

This gene has 4 transcripts (splice variants), 149 orthologues and 22 paralogues. Ubiquitous expression in gall bladder (RPKM 9.9), lung (RPKM 9.2) and 23 other tissues.

Summary

This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]

RHOJ Products(1)

mRNA	Protein	Name
NM_020663.5	NP_065714.1	rho-related GTP-binding protein RhoJ

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	27660391	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	27660391	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	10967094	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	28727754	GOA
involved in regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	30158707	GOA
involved in regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	21628409	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	27660391	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOJ Protein Structure

Ras

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

rho-related GTP-binding protein RhoJ

RAS-like, family 7, member B

Related Diseases

Diseases

Alias

Parasitic Ichthyosporea Infectious Disease

Rhinosporidiosis

Infection By Rhinosporidium Seeberi

Rhinosporosis

Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy	Patterned Macular Dystrophy 3
MDPT3	Mcrpe

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11955	RHOJ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-167828	ARN25062	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RHOJ	VGNC	VGNC:76885
Felis catus	RHOJ	VGNC	VGNC:80867
Bos taurus	RHOJ	VGNC	VGNC:33951
Canis familiaris	RHOJ	VGNC	VGNC:45562
Rattus norvegicus	RHOJ	RGD	RGD:1310528
Mus musculus	RHOJ	MGD	MGI:1931551

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