RHOJ - ras homolog family member J Gene

Homo sapiens

Also known as TCL; ARHJ; TC10B; RASL7B

Gene ID: 57381 | Gene type: protein coding

About RHOJ

Cytogenetic location: 14q23.2 Genomic coordinates (GRCh38): 14:63,204,443-63,293,508 (from NCBI)

This gene has 4 transcripts (splice variants), 149 orthologues and 22 paralogues. Ubiquitous expression in gall bladder (RPKM 9.9), lung (RPKM 9.2) and 23 other tissues.

Summary

This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]

RHOJ Products(1)

mRNA	Protein	Name
NM_020663.5	NP_065714.1	rho-related GTP-binding protein RhoJ

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	27660391	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	27660391	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	10967094	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	28727754	GOA
involved in regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	30158707	GOA
involved in regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	21628409	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	27660391	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOJ Protein Structure

Ras

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

rho-related GTP-binding protein RhoJ

RAS-like, family 7, member B

RHOJ Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RHOJ	Q9H4E5	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	SSX3	Homo sapiens	Q99909	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	SSX3	Homo sapiens	Q99909	Anti Tag CoIP	25416956
Intra	RHOJ	Q9H4E5	PAK2	Homo sapiens	Q13177	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	PAK2	Homo sapiens	Q13177	Anti Tag CoIP	33961781
Intra	RHOJ	Q9H4E5	PAK2	Homo sapiens	Q13177	Y2H Prey Pooling	25416956
Intra	RHOJ	Q9H4E5	PAK2	Homo sapiens	Q13177	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	PAK6	Homo sapiens	Q9NQU5	Y2H Array	31515488
Intra	RHOJ	Q9H4E5	PAK6	Homo sapiens	Q9NQU5	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	RHOJ	Q9H4E5	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	RHOJ	Q9H4E5	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	RHOJ	Q9H4E5	PAK1	Homo sapiens	Q13153	Anti Tag CoIP	33961781
Intra	RHOJ	Q9H4E5	PAK1	Homo sapiens	Q13153	Validated Y2H	32814053
Intra	RHOJ	Q9H4E5	PAK1	Homo sapiens	Q13153	Y2H Array	32814053
Intra	RHOJ	Q9H4E5	PAK1	Homo sapiens	Q13153	Y2H Pooling	32814053
Intra	RHOJ	Q9H4E5	PAK3	Homo sapiens	O75914-2	Y2H Array	32296183
Intra	RHOJ	Q9H4E5	PAK3	Homo sapiens	O75914-2	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	25416956
Intra	RHOJ	Q9H4E5	PARD6B	Homo sapiens	Q9BYG5	Y2H Array	32296183
Intra	RHOJ	Q9H4E5	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	33961781
Intra	RHOJ	Q9H4E5	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	PARD6B	Homo sapiens	Q9BYG5	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	PARD6B	Homo sapiens	Q9BYG5	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RHOJ	Q9H4E5	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RHOJ	Q9H4E5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RHOJ	Q9H4E5	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RHOJ	Q9H4E5	CRYAA	Homo sapiens	P02489	Y2H Array	32814053
Intra	RHOJ	Q9H4E5	CRYAA	Homo sapiens	P02489	Y2H Pooling	32814053
Intra	RHOJ	Q9H4E5	CRYAA	Homo sapiens	P02489	Validated Y2H	32814053
Intra	RHOJ	Q9H4E5	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	TRIP10	Homo sapiens	Q15642	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	TRIP10	Homo sapiens	Q15642	Y2H Prey Pooling	25416956
Intra	RHOJ	Q9H4E5	PAK5	Homo sapiens	Q9P286	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	PAK5	Homo sapiens	Q9P286	Validated Y2H	32296183
Intra	RHOJ	Q9H4E5	PAK5	Homo sapiens	Q9P286	Y2H Array	32296183
Intra	RHOJ	Q9H4E5	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	32296183
Intra	RHOJ	Q9H4E5	CDC42EP1	Homo sapiens	Q00587	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	GLUL	Homo sapiens	P15104	Anti Bait CoIP	30158707
Intra	RHOJ	Q9H4E5	WASL	Homo sapiens	O00401	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	WASL	Homo sapiens	O00401	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	WASL	Homo sapiens	O00401	Y2H Prey Pooling	25416956
Intra	RHOJ	Q9H4E5	WASL	Homo sapiens	O00401	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	WASL	Homo sapiens	O00401	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Parasitic Ichthyosporea Infectious Disease

Rhinosporidiosis

Infection By Rhinosporidium Seeberi

Rhinosporosis

Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy	Patterned Macular Dystrophy 3
MDPT3	Mcrpe

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11955	RHOJ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-167828	ARN25062	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RHOJ	VGNC	VGNC:76885
Felis catus	RHOJ	VGNC	VGNC:80867
Bos taurus	RHOJ	VGNC	VGNC:33951
Canis familiaris	RHOJ	VGNC	VGNC:45562
Rattus norvegicus	RHOJ	RGD	RGD:1310528
Mus musculus	RHOJ	MGD	MGI:1931551

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