CIAO1 - cytosolic iron-sulfur assembly component 1 Gene

Homo sapiens

Also known as CIA1; WDR39

Gene ID: 9391 | Gene type: protein coding

About CIAO1

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,266,225-96,274,173 (from NCBI)

This gene has 4 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in adrenal (RPKM 18.1), kidney (RPKM 17.3) and 25 other tissues.

Summary

Involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in cytoplasm. Part of CIA complex and MMXD complex. [provided by Alliance of Genome Resources, Apr 2022]

CIAO1 Products(1)

mRNA	Protein	Name
NM_004804.3	NP_004795.1	probable cytosolic iron-sulfur protein assembly protein CIAO1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in iron-sulfur cluster assembly	IGI IGI: Inferred from genetic interaction	17937914	GOA
involved in iron-sulfur cluster assembly	IMP IMP: Inferred from mutant phenotype	23891004	GOA
involved in protein maturation by iron-sulfur cluster transfer	IMP IMP: Inferred from mutant phenotype	23891004	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MMXD complex	IDA IDA: Inferred from direct assay	20797633	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23585563	GOA
part of cytosolic [4Fe-4S] assembly targeting complex	IDA IDA: Inferred from direct assay	22678361	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIAO1 Protein Structure

WD40

0
100
200
300
339 a.a.

Protein Preferred Names

Protein Names

probable cytosolic iron-sulfur protein assembly protein CIAO1

WD repeat domain 39

CIAO1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CIAO1	O76071	MMS19	Homo sapiens	Q96T76-8	Y2H Array	25416956
Intra	CIAO1	O76071	MMS19	Homo sapiens	Q96T76-8	Y2H Prey Pooling	25416956
Intra	CIAO1	O76071	MMS19	Homo sapiens	Q96T76	Anti Bait CoIP	17353931
Intra	CIAO1	O76071	MMS19	Homo sapiens	Q96T76	Anti Tag CoIP	28178521
Intra	CIAO1	O76071	MMS19	Homo sapiens	Q96T76	TAP	24981860
Intra	CIAO1	O76071	SLC4A7	Homo sapiens	Q9Y6M7	Y2H Prey Pooling	32296183
Intra	CIAO1	O76071	SLC4A7	Homo sapiens	Q9Y6M7	Validated Y2H	32296183
Intra	CIAO1	O76071	SLC4A7	Homo sapiens	Q9Y6M7	Y2H Array	32296183
Intra	CIAO1	O76071	SHISA6	Homo sapiens	Q6ZSJ9	Y2H Array	32296183
Intra	CIAO1	O76071	SHISA6	Homo sapiens	Q6ZSJ9	Y2H Prey Pooling	32296183
Intra	CIAO1	O76071	SHISA6	Homo sapiens	Q6ZSJ9	Validated Y2H	32296183
Intra	CIAO1	O76071	ANKRD55	Homo sapiens	Q3KP44	Validated Y2H	32296183
Intra	CIAO1	O76071	ANKRD55	Homo sapiens	Q3KP44	Y2H Prey Pooling	32296183
Intra	CIAO1	O76071	ANKRD55	Homo sapiens	Q3KP44	Y2H Array	32296183
Intra	CIAO1	O76071	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CIAO1	O76071	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CIAO1	O76071	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	CIAO1	O76071	C19orf2	Homo sapiens	Q6NX55	Y2H Array	32296183
Intra	CIAO1	O76071	C19orf2	Homo sapiens	Q6NX55	Y2H Prey Pooling	32296183
Intra	CIAO1	O76071	C19orf2	Homo sapiens	Q6NX55	Validated Y2H	32296183
Intra	CIAO1	O76071	HAUS3	Homo sapiens	Q68CZ6	Y2H Array	32296183
Intra	CIAO1	O76071	HAUS3	Homo sapiens	Q68CZ6	Y2H Prey Pooling	32296183
Intra	CIAO1	O76071	HAUS3	Homo sapiens	Q68CZ6	Validated Y2H	32296183
Intra	CIAO1	O76071	MEOX1	Homo sapiens	P50221	Y2H Array	25416956
Intra	CIAO1	O76071	TOP3B	Homo sapiens	O95985	Validated Y2H	32296183
Intra	CIAO1	O76071	TCP10L	Homo sapiens	Q8TDR4	Validated Y2H	32296183
Intra	CIAO1	O76071	TCP10L	Homo sapiens	Q8TDR4	Y2H Prey Pooling	32296183
Intra	CIAO1	O76071	TCP10L	Homo sapiens	Q8TDR4	Y2H Array	32296183
Intra	CIAO1	O76071	ERCC2	Homo sapiens	P18074	Anti Tag CoIP	23585563
Intra	CIAO1	O76071	RGS2	Homo sapiens	P41220	Y2H Prey Pooling	32296183
Intra	CIAO1	O76071	RGS2	Homo sapiens	P41220	Validated Y2H	32296183
Intra	CIAO1	O76071	RGS2	Homo sapiens	P41220	Y2H Array	32296183
Intra	CIAO1	O76071	CIAO2B	Homo sapiens	Q9Y3D0	Y2H Array	32296183
Intra	CIAO1	O76071	CIAO2B	Homo sapiens	Q9Y3D0	Anti Tag CoIP	28178521
Intra	CIAO1	O76071	CIAO2B	Homo sapiens	Q9Y3D0	Y2H Prey Pooling	32296183
Intra	CIAO1	O76071	CIAO2B	Homo sapiens	Q9Y3D0	TAP	24981860
Intra	CIAO1	O76071	CIAO2B	Homo sapiens	Q9Y3D0	Y2H Pooling	16189514
Intra	CIAO1	O76071	CIAO2B	Homo sapiens	Q9Y3D0	Validated Y2H	32296183
Intra	CIAO1	O76071	CIAO2B	Homo sapiens	Q9Y3D0	Y2H Array	25416956
Intra	CIAO1	O76071	SF1	Homo sapiens	Q15637	Y2H Prey Pooling	25416956
Intra	CIAO1	O76071	SF1	Homo sapiens	Q15637	Validated Y2H	25416956
Intra	CIAO1	O76071	CIAO2A	Homo sapiens	Q9H5X1	Y2H Prey Pooling	25416956
Intra	CIAO1	O76071	CIAO2A	Homo sapiens	Q9H5X1	Y2H Prey Pooling	32296183
Intra	CIAO1	O76071	CIAO2A	Homo sapiens	Q9H5X1	Validated Y2H	32296183
Intra	CIAO1	O76071	CIAO2A	Homo sapiens	Q9H5X1	Y2H Array	25416956
Intra	CIAO1	O76071	CIAO2A	Homo sapiens	Q9H5X1	Y2H Array	32296183
Intra	CIAO1	O76071	CIAO2A	Homo sapiens	Q9H5X1	TAP	24981860
Intra	CIAO1	O76071	CIAO2A	Homo sapiens	Q9H5X1	Y2H Pooling	16189514
Intra	CIAO1	O76071	CIAO2A	Homo sapiens	Q9H5X1	GMS	32222833

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6

Mitochondrial Dna Deletion Syndrome With Progressive Myopathy	PEOA6
Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 6	Dna2-Related Mitochondrial Dna Deletion Syndrome
Mitochondrial Dna Deletion Syndrome With Limb-Girdle Weakness	Mtdna Deletion Syndrome With Limb-Girdle Weakness
Mtdna Deletion Syndrome With Progressive Myopathy	Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 6
Progressive External Ophthalmoplegia, Autosomal Dominant 6	Autosomal Dominant Progressive External Ophthalmoplegia 6
Progressive External Ophthalmoplegia Autosomal Dominant 6	Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 6

Xeroderma Pigmentosum, Complementation Group D

Xeroderma Pigmentosum, Group D	Xpdc
Xeroderma Pigmentosum Iv	XPD
Xeroderma Pigmentosum Group D	Xeroderma Pigmentosum Viii
Xp Group D	Xp Group H
Xp4	Xp8
Xph	Xp, Group D
Xp4 Xeroderma Pigmentosum Viii, Formerly	Xp8, Formerly
Xp, Group H, Formerly	Xph, Formerly
Xeroderma Pigmentosum Complementation Group D	XP-D
Xp-D/Cs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02702	CIAO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CIAO1	MGD	MGI:1346998
Canis familiaris	CIAO1	VGNC	VGNC:39263
Felis catus	CIAO1	VGNC	VGNC:80065
Rattus norvegicus	CIAO1	RGD	RGD:1307285
Macaca mulatta	CIAO1	VGNC	VGNC:70950
Bos taurus	CIAO1	VGNC	VGNC:27356
Others	CIAO1	NCBI

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