2. Gene
  3. MED27 - mediator complex subunit 27 Gene

MED27 - mediator complex subunit 27 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MED3; CRSP8; CRAP34; CRSP34; TRAP37; NEDSCAC

Gene ID: 9442 | Gene type: protein coding

About MED27

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:131,860,112-132,079,867 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 2.5), brain (RPKM 2.0) and 25 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of Other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

MED27 Products(3)

mRNA Protein Name
NM_001253881.2 NP_001240810.1 mediator of RNA polymerase II transcription subunit 27 isoform 2
NM_001253882.2 NP_001240811.1 mediator of RNA polymerase II transcription subunit 27 isoform 3
NM_004269.4 NP_004260.2 mediator of RNA polymerase II transcription subunit 27 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12584197 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
9989412 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9989412 GOA
Cellular Component GO Annotation Evidence Reference Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9989412 GOA
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9989412 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED27 Protein Structure

Med27

Med27: Mediator complex subunit 27 (228 - 310)

  • 0
  • 100
  • 200
  • 311 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 27

CRSP complex subunit 8

MED27 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
MED27 Q6P2C8 Med30 Mus musculus Q9CQI9
Pull Down
12584197
Cross
MED27 Q6P2C8 Med30 Mus musculus Q9CQI9
Anti Tag CoIP
24882805
Intra
MED27 Q6P2C8 MED17 Homo sapiens Q9NVC6
Anti Tag CoIP
24882805
Intra
MED27 Q6P2C8 MED17 Homo sapiens Q9NVC6
Anti Tag CoIP
35271311
Intra
MED27 Q6P2C8 MED6 Homo sapiens O75586
Anti Tag CoIP
24882805
Intra
MED27 Q6P2C8 MED6 Homo sapiens O75586
Anti Tag CoIP
35271311
Intra
MED27 Q6P2C8 MED22 Homo sapiens Q15528
Anti Tag CoIP
24882805
Intra
MED27 Q6P2C8 MED22 Homo sapiens Q15528
Anti Tag CoIP
35271311
Intra
MED27 Q6P2C8 MED22 Homo sapiens Q15528
Pull Down
12584197
Intra
MED27 Q6P2C8 MED28 Homo sapiens Q9H204
Anti Tag CoIP
24882805
Intra
MED27 Q6P2C8 MED28 Homo sapiens Q9H204
Anti Tag CoIP
35271311
Cross
MED27 Q6P2C8 Med8 Mus musculus Q9D7W5
Anti Tag CoIP
24882805
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Spasticity, Cataracts, And Cerebellar Hypoplasia

NEDSCAC
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Cerebellar Hypoplasia
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Cerebellar Medulloblastoma
Bubonic Plague

Black Death

Plague, Bubonic

Plague, Septicemic

Pestis Bubonica
Occupational Dermatitis

Dermatitis, Occupational

Occupational Allergic Contact Dermatitis

Occupational Eczema
Pneumonic Plague

Primary Pneumonic Plague

Secondary Pneumonic Plague

Plague

Plague, Pneumonic

Plague Pneumonia

Plague Of Lung

Pulmonary Plague

Pneumonia Due To Yersinia Pestis
Plague

Yersiniosis

Yersinia Infections

Infection By Yersinia Pestis

Pasteurella Pestis Infection

Pestilential Fever

Yersinia Pestis Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08298 MED27 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MED27 MGD MGI:1916225
Macaca mulatta MED27 VGNC VGNC:74563
Felis catus MED27 VGNC VGNC:63440
Rattus norvegicus MED27 RGD RGD:1564993
Bos taurus MED27 VGNC VGNC:31363
Canis familiaris MED27 VGNC VGNC:43134