2. Gene
  3. MED6 - mediator complex subunit 6 Gene

MED6 - mediator complex subunit 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ARC33; NY-REN-28

Gene ID: 10001 | Gene type: protein coding

About MED6

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,583,221-70,600,655 (from NCBI)

This gene has 12 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in lymph node (RPKM 6.4), ovary (RPKM 5.9) and 25 other tissues.

Summary

Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]

MED6 Products(4)

mRNA Protein Name
NM_001284209.2 NP_001271138.1 mediator of RNA polymerase II transcription subunit 6 isoform 1
NM_001284210.2 NP_001271139.1 mediator of RNA polymerase II transcription subunit 6 isoform 3
NM_001284211.2 NP_001271140.1 mediator of RNA polymerase II transcription subunit 6 isoform 4
NM_005466.4 NP_005457.2 mediator of RNA polymerase II transcription subunit 6 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14576168 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
12037571 GOA
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
17641689 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12037571 GOA
Cellular Component GO Annotation Evidence Reference Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
part of mediator complex IDA
IDA: Inferred from direct assay
12037571 GOA
part of mediator complex IMP
IMP: Inferred from mutant phenotype
17641689 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24882805 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED6 Protein Structure

Med6

Med6: MED6 mediator sub complex component (13 - 141)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 6

CTD-2540L5.5

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08304 MED6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-169233 MED6-189 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MED6 MGD MGI:1917042
Canis familiaris MED6 VGNC VGNC:43140
Rattus norvegicus MED6 RGD RGD:1310296
Macaca mulatta MED6 VGNC VGNC:74539
Felis catus MED6 VGNC VGNC:80916
Bos taurus MED6 VGNC VGNC:31369