2. Gene
  3. MED20 - mediator complex subunit 20 Gene

MED20 - mediator complex subunit 20 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SRB2; TRFP; PRO0213

Gene ID: 9477 | Gene type: protein coding

About MED20

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,905,354-41,921,139 (from NCBI)

This gene has 7 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in placenta (RPKM 6.7), thyroid (RPKM 6.0) and 25 other tissues.

Summary

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

MED20 Products(4)

mRNA Protein Name
NM_001305455.2 NP_001292384.1 mediator of RNA polymerase II transcription subunit 20 isoform 2
NM_001305456.2 NP_001292385.1 mediator of RNA polymerase II transcription subunit 20 isoform 2
NM_001305457.2 NP_001292386.1 mediator of RNA polymerase II transcription subunit 20 isoform 3
NM_004275.5 NP_004266.2 mediator of RNA polymerase II transcription subunit 20 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14576168 GOA
Cellular Component GO Annotation Evidence Reference Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24882805 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED20 Protein Structure

Med20

Med20: TATA-binding related factor (TRF) of subunit 20 of Mediator complex (1 - 198)

  • 0
  • 100
  • 200
  • 212 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 20

Trf (TATA binding protein-related factor)-proximal homolog

Related Diseases

Diseases Alias
Immune System Organ Benign Neoplasm
Thymus Lipoma

Thymolipoma
Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma
Compensatory Emphysema
Mediastinal Cancer

Mediastinal Neoplasms

Mediastinal Tumor

Mediastinum Cancer

Neoplasm Of Mediastinum

Tumour Of Mediastinum

Malignant Tumor Of Mediastinum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08291 MED20 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MED20 RGD RGD:1306415
Bos taurus MED20 VGNC VGNC:31357
Canis familiaris MED20 VGNC VGNC:43129
Felis catus MED20 VGNC VGNC:63436
Mus musculus MED20 MGD MGI:1929648
Macaca mulatta MED20 VGNC VGNC:74520